A5016246082- Cardiomyopathy and Myosin Studies
- Urological Disorders and Treatments
- Cardiovascular Function and Risk Factors
- Pediatric Urology and Nephrology Studies
- Urinary and Genital Oncology Studies
- Renal cell carcinoma treatment
- Glutathione Transferases and Polymorphisms
- Sarcoma Diagnosis and Treatment
- Prostate Cancer Diagnosis and Treatment
- Eicosanoids and Hypertension Pharmacology
- Veterinary Oncology Research
- Atrial Fibrillation Management and Outcomes
- Renal and related cancers
- Epigenetics and DNA Methylation
- Genital Health and Disease
- Diptera species taxonomy and behavior
- Trypanosoma species research and implications
- Ureteral procedures and complications
- Medical Imaging Techniques and Applications
- Historical Psychiatry and Medical Practices
- Metastasis and carcinoma case studies
- Diet, Metabolism, and Disease
- Diagnosis and treatment of tuberculosis
- Neurological Disorders and Treatments
- Actinomycetales infections and treatment
University of Szeged
2006-2025
Univerzitná Nemocnica Louisa Pasteura
2013-2021
University of Veterinary Medicine in Košice
2010-2015
University of Pavol Jozef Šafárik
1997-2014
Semmelweis University
1996-2010
Abstract Background Sarcomere gene mutations is hypertrophic cardiomyopathy (HCM) can have prognostic value and role in risk assessment, according to numerous studies. In our previous investigations, we confirmed that echocardiographic parameters of left ventricular (LV) myocardial work (MW) derived from the non-invasive pressure-strain curve were reduced patients with HCM, especially case clinical features advanced disease. The aim present was investigate MW genotyped HCM patients. Patients...
Abstract Introduction Mavacamten is a selective, allosteric and reversible cardiac myosin inhibitor indicated for the treatment of symptomatic (NYHA II-III class) adult patients with obstructive [≥ 50 mmHg resting or provokable left ventricular outflow tract (LVOT) peak gradient] hypertrophic cardiomyopathy (HOCM). Patients Methods Ten HOCM [5 men (50%), mean age: 57±11 years) were treated mavacamten. In 9 provoked gradient was >100 Hgmm. addition to recording main demographic,...
Abstract Introduction Mavacamten is a novel therapy for hypertrophic obstructive cardiomyopathy. Left ventricular (LV) ejection fraction (EF) has been used monitoring of left systolic function during therapy. Currently there limited data on advanced functional parameters based speckle tracking strain values, such as global longitudinal (GLS) , myocardial work (MW) or 3D echocardiography. MW an emerging method which incorporates pressure and provides multiple LV pressure-strain loop. This...
Abstract Introduction Decompensated acute heart failure (HF) in patients with reduced ejection fraction (HFrEF) signifies a pivotal stage the progression of chronic HF. This condition is closely linked to increased rates rehospitalization and higher risk mortality morbidity due inadequate decongestion. Recently, field quantitative echocardiography has experienced significant advancements, particularly myocardial work analysis (MWA), which measures energy uses during each cardiac cycle....
<b><i>Objective:</i></b> To assess the current microbiological profile and sensitivity to antibiotics in patients with acute bacterial prostatitis (ABP). <b><i>Patients Methods:</i></b> In period 2003–2010, we treated 192 ABP patients, aged from 18 85 years (average 56.3 years). We performed a biochemical examination including urine examination. After admission, immediately began empirical antibacterial treatment....
Atrial fibrillation is the most common arrhythmia after cardiac surgery. The pathogenesis of postoperative atrial multifactorial. aim study was to analyse preoperative, intraoperative and factors their relationships with occurrence duration fibrillation.One hundred ninety-six patients coronary heart disease (152 men, age 62.7 ± 10.1 years) underwent surgical revascularization. Extracorporeal circulation used in 64 minimal extracorporeal 75 patients. Fifty-seven surgery without circulation....
Polymorphisms in tobacco carcinogen metabolizing enzymes may generate interindividual variations towards the risk of developing prostate cancer.One these is microsomal epoxide hydrolase (EPHX1) which metabolizes polycyclic aromatic hydrocarbons, or PAH, carcinogens found cigarette smoke.The activity this enzyme affected by two polymorphisms, a substitution Tyr113 His exon 3 and His139 Arg 4. The aim study was to use population-based case-control investigate whether not such genetic...
Abstract The aim of this work was to determine levels carcinoembryonic antigen ( CEA ) and cancer CA 15‐3) in the blood serum 45 bitches. A modified procedure used 15‐3 markers with human kits using radioimmunoassay method. Samples collected from extirpated tumour mammary glands were histologically processed classified as per WHO guidelines. average age animals 10.00 ± 2.2 years; for healthy bitches 4.2 3.2 years. Values considered positive, if they exceeded 0.23 ng mL −1 7 IU ,...
The aim of this study was to determine reference values carcinoembryonic antigen and cancer in 32 clinically healthy bitches. average age the bitches each group as follows: small breeds 3.50 ± 2.30, medium 3.83 3.21, large 6.00 3.22 giant 2.40 2.43. weight 1st 7.94 kg 1.84, 2nd 22.38 2.77, 3rd 35.94 7.16, 4th 52.75 5.04. markers were determined using human kits. mean carcinoembryotic SD 0.18 0.03, 0.20 0.22 0.01, 0.04. statistical significance for P = 0.0042**. were: 4.90 1.04, 4.80 1.13,...
Prostate cancer (PCa) represents one of the most complicated human tumors and, like many others malignancies, arises from progressive genetic and epigenetic alterations. Among all recognized alterations, aberrant DNA methylation (hypo- hypermethylation) is important best characterized change in PCa.We analyzed GSTP1, APC RASSF1 gene promoter hypermethylation urine ten previously non-treated prostate-diseased patients.For purpose, quantitative real-time specific PCR (MSP) with primers...
The aim of the paper is to determine whether IGF1, IGFBP3 and IGF1/IGFBP3 molar ratio in addition PSA one-nucleotide polymorphism CYP17 gene might contribute early diagnostics prostate cancer (PCa). Serum level PSA, IGF1 group 158 individuals (92 PCa 66 controls) was examined by RIA method calculated. PCR RLFP used examine one- nucleotide CYP 17 gene. results suggest that serum over 95% CI did not increase relative risk development overall group, even regarding particular investigated...
The aim of this study was to analyze the results surgical and conservative treatment non-refluxing POM. In period 2000-2009, 45 children (52 ureters) were treated, average age 5.8 months (±10.33), 24 (26 by surgery (I) 21 means (II). follow-up 73.8 (±32.91) 30.85 (±23.1) resp. Urine examination, USG, DTPA99mTc, biochemical testing, micturating cystouretography in all patients performed. Significant difference present occurrence hydronephrosis 0th, 3rd 4th grade, p10 mm, p<0.01; normal...
Sarcomatous renal cell carcinomas (SRCCs) originate from a dedifferentiation of carcinoma (RCC). They are characterized by an aggressive course and very poor prognosis. Less known is their ability to imitate inflammatory diseases the kidney. The aim study was outline less usual symptoms SRCCs in retrospective analysis 180 patients operated for RCC 1997–2001. In 11 (6.1%) (8 men 3 women, age 40–76 years, mean 60 years) SRCC present. pTNM classification, results histological examination, stage...
1. Vasilková D, Klisenbauer Juhás T, et al. Isolation of Dirofilaria repens in a vitreoretinal lesion. Cesk Oftalmol. 1992;48(4):274–80. Google Scholar
Abstract In this case report, we describe a unique of highly motivated patient who tried to solve his problem with redundant foreskin by sophisticated, thoughtful method. Dissatisfaction the made it difficult for him establish intimate contact. After studying operation on Internet, he performed self‐circumcision.
We report a case of complete scrotal bladder hernia with both ureters presenting as dysuria, bilateral ureterohydronephrosis, and acute renal insuffi ciency.A 37-year-old man recurrent large mass after two surgeries, suffering small urinary symptoms dysuria nocturia, was examined before the third surgery on an outpatient basis.Urological examination revealed negative urine, ureterohydronephrosis USG, serum creatinine 231-250 μmol/l.CT displayed completely herniated into scrotum distal parts...
Abstract Background Coronary flow velocity reserve (CFVR) can be assessed with transthoracic echocardiography (TTE) as the stress/rest ratio of coronary (CFV). Reduced CFVR during vasodilator stress (adenosine or dipyridamole) is a powerful predictor adverse outcomes in hypertrophic cardiomyopathy (HCM). However, feasibility and correlates more physiological - recommended exercise (ESE) unresolved. Aim To assess functional HCM. Methods We studied 56 HCM patients (age=49±13 years, 33 [59%]...