A5000751016- Cardiomyopathy and Myosin Studies
- Cardiac electrophysiology and arrhythmias
- Cardiovascular Function and Risk Factors
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Cardiac Arrhythmias and Treatments
- Cardiovascular Effects of Exercise
- Peptidase Inhibition and Analysis
- Heart Failure Treatment and Management
- Parathyroid Disorders and Treatments
- Ion channel regulation and function
- Galectins and Cancer Biology
- Frailty in Older Adults
- Lysosomal Storage Disorders Research
- Pharmaceutical studies and practices
- COVID-19 Clinical Research Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Magnesium in Health and Disease
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Mitochondrial Function and Pathology
- Advanced MRI Techniques and Applications
- Congenital Heart Disease Studies
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
- Atrial Fibrillation Management and Outcomes
- Healthcare Systems and Public Health
University of Szeged
2015-2025
University of Pecs
2020-2022
Semmelweis University
2022
SeqOmics Biotechnology (Hungary)
2022
University of Liverpool
2016
Liverpool Heart and Chest Hospital
2016
AlbaNova
2016
Spiber Technologies (Sweden)
2016
Tampere University
2016
Abstract Aims The early diagnosis of cardiac amyloidosis (CA) is paramount, since there are effective therapies that improve patient survival. diagnostic accuracy classical electrocardiographic (ECG) signs, such as low voltage, pseudoinfarct pattern, and conduction disturbances in the CA, inferior to echocardiographic myocardial deformation criteria; therefore, our aim was find more accurate novel ECG criteria for this purpose. Methods We tested value five criteria, two them devised by us,...
Abstract Background Sarcomere gene mutations is hypertrophic cardiomyopathy (HCM) can have prognostic value and role in risk assessment, according to numerous studies. In our previous investigations, we confirmed that echocardiographic parameters of left ventricular (LV) myocardial work (MW) derived from the non-invasive pressure-strain curve were reduced patients with HCM, especially case clinical features advanced disease. The aim present was investigate MW genotyped HCM patients. Patients...
Abstract Introduction Mavacamten is a selective, allosteric and reversible cardiac myosin inhibitor indicated for the treatment of symptomatic (NYHA II-III class) adult patients with obstructive [≥ 50 mmHg resting or provokable left ventricular outflow tract (LVOT) peak gradient] hypertrophic cardiomyopathy (HOCM). Patients Methods Ten HOCM [5 men (50%), mean age: 57±11 years) were treated mavacamten. In 9 provoked gradient was >100 Hgmm. addition to recording main demographic,...
Abstract Introduction Mavacamten is a novel therapy for hypertrophic obstructive cardiomyopathy. Left ventricular (LV) ejection fraction (EF) has been used monitoring of left systolic function during therapy. Currently there limited data on advanced functional parameters based speckle tracking strain values, such as global longitudinal (GLS) , myocardial work (MW) or 3D echocardiography. MW an emerging method which incorporates pressure and provides multiple LV pressure-strain loop. This...
Abstract Introduction Decompensated acute heart failure (HF) in patients with reduced ejection fraction (HFrEF) signifies a pivotal stage the progression of chronic HF. This condition is closely linked to increased rates rehospitalization and higher risk mortality morbidity due inadequate decongestion. Recently, field quantitative echocardiography has experienced significant advancements, particularly myocardial work analysis (MWA), which measures energy uses during each cardiac cycle....
Hypertrophic cardiomyopathy (HCM) is a primary disease of the myocardium most commonly caused by mutations in sarcomeric genes. We aimed to perform nationwide large-scale genetic analysis previously unreported, representative HCM cohort Hungary. A total 242 consecutive index patients (127 men, 44 ± 11 years) were studied with next generation sequencing using custom-designed gene-panel comprising 98 cardiomyopathy-related 90 (37%) carried pathogenic/likely pathogenic (P/LP) variants. The...
Although the clinical manifestations of SARS-CoV-2 viral infection affect mainly respiratory system, cardiac complications are common and associated with increased morbidity mortality. While echocardiographic alterations indicating myocardial involvement widely reported in patients hospitalized for acute COVID-19 infection, much fewer data available non-hospitalized, mildly symptomatic patients. In our work, we aimed to investigate subclinical characterized by parameters provided advanced...
Background: Variant transthyretin amyloidosis (ATTRv) is an autosomal dominant inherited disease, where the mutation of gene (TTR) results in deposition pathogenic protein fibrils various tissues. The type influences clinical course. Until now, no data were available on genotype, phenotype, and prevalence Hungarian ATTRv patients. aim our study was to assess prevalence, regional distribution, genotypes, phenotypes patients with ATTRv. Methods: With collaboration university centers, we...
In the present study, effect of long-term exercise training was investigated on myocardial morphological and functional remodeling proarrhythmic sensitivity in a rabbit athlete’s heart model. New-Zealand white rabbits were trained during 12-week long treadmill running protocol compared with their sedentary controls. At end protocol, echocardiography, vivo vitro ECG recordings, dofetilide (nM) performed isolated hearts, action potential duration (APD) measurements at different potassium...
A mineralokortikoidreceptor-antagonista (MRA) szerek randomizált klinikai vizsgálatok alapján nagyon hatékony terápiás lehetőségnek bizonyultak a csökkent ejekciós frakciójú szívelégtelenségben (HFrEF) szenvedő betegek kezelésében. Ezekben betegekben jelenlegi bizonyítékok azt mutatják, hogy az MRA-k csökkentik morbiditását és mortalitását. három nagy, HFrEF-betegeket bevonó vizsgálat (RALES, EPHESUS, EMPHASIS-HF) eredményei mind spironolakton, eplerenon bekerült HFrEF-betegcsoport...
Az Európai Kardiológus Társaság (European Society of Cardiology, ESC) akut és krónikus szívelégtelenség (SZE) diagnosztizálására kezelésére vonatkozó 2021. évi irányelvének közzététele óta számos randomizált, kontrollált klinikai vizsgálat eredményét publikálták. Utóbbi vizsgálatok olyan ismeretanyagot szolgáltattak, amelyeknek közvetlen kihatásuk van a napi gyakorlatra az SZE-betegek kezelését illetően. Ezen megfontolás alapján szükségesnek tűnt ajánlások frissítése, még következő tervezett...
A szívamyloidosis egy súlyos, progresszív, infiltratív betegség, amelyet amiloidfibrillumok szívizomban való lerakódása okoz. Hátterében általában hematológiai, krónikus gyulladásos betegségek, illetve genetikai eltérések állhatnak, de az időskorban jellemző forma esetében a pontos ok ismeretlen. Az utóbbi években modern képalkotó eljárásoknak és noninvazív diagnosztika lehetőségének, valamint egyre több, hatásos betegség specifikus terápiának köszönhetően növekszik diagnosztizált esetek...
Hypertrophic cardiomyopathy (HCM) is the most common genetic cardiovascular disorder worldwide which exhibits considerable heterogeneity. Widespread utilization of next-generation sequencing (NGS) in HCM has uncovered substantial variation and highlighted importance a standardized approach to variant interpretation. According this, accurate consistent interpretation sequence variants essential for effective clinical care individuals their families with HCM. With this regard, 2015 guidelines...
Háttér: A hipertrófiás cardiomyopathia (HCM), és annak fenotípusát utánzó HCM-fenokópiák, pl. a Fabry-betegség kardiális manifesztációjának differenciáldiagnosztikai elkülönítése jelentős nehézséget okozhat mindennapi klinikai gyakorlatban. Esetismertetés: jelen észlelésekor 55 éves férfi beteg korábbi anamnézisében hipertónia, több alkalommal hipertenzív excessus miatti kórházi felvétel, ateroszklerózis, COPD, veseérintettség stroke szerepelt. Egyre fokozódó fulladás kifejezett terhelési...
The Lambeth Conventions (LC I), a landmark guidance document for arrhythmia research was updated and definitions were changed in the new II II). This study examined whether of LC I yield same qualitative results improves inter-observer agreement. Two independent investigators performed blinded analysis electrocardiograms isolated, Langendorff rat hearts subjected to regional ischemia perfused with Class antiarrhythmics 3 or 5 mM K+ perfusate. Data obtained compared within between observers....
ban HCM-es betegekben vizsgáltuk a BKH jellemzésére tradicionálisan használt paraméterek és szív-MRI-vel pontosan meghatározott bal kamrai izomtömeg (BKIT) közötti összefüggést
Háttér: A hipertrófiás cardiomyopathia (HCM) a myocardium primer betegsége, amelyet típusosan sarcomerfehérjéket kódoló gének mutációi okoznak. cardiomyopathiát utánzó HCM-fenokópiák, pl. Fabry-betegség kardiális manifesztációjának elkülönítése, adott esetben jelentős differenciáldiagnosztikai nehézséget okozhat. Esetismertetés: Munkánkban egy HCM fenotípusával rendelkező nőbeteg részletes genetikai analízisét végeztük el. Az első észlelésekor 49 éves szinte állandóan fennálló mellkasi...
Several heart muscle diseases can cause failure, the etiological diagnosis of which may serve basis targeted, tailored, effective personalized therapy. Such a disease is transthyretin amyloidosis (ATTR) an infiltrative disorder affecting most frequently and peripheral nerves, due to accumulation protein. Deposition mutant transthyretin, mutations in TTR gene encoding for occurs familial form (hATTR), while senile amyloidosis, wild-type accumulates (wtATTR). We report on 79-years-old male...