A5001340066- Cardiovascular Function and Risk Factors
- Blood Pressure and Hypertension Studies
- Cardiomyopathy and Myosin Studies
- Cardiac Imaging and Diagnostics
- Cardiovascular Health and Disease Prevention
- Cardiac Valve Diseases and Treatments
- Atrial Fibrillation Management and Outcomes
- Heart Rate Variability and Autonomic Control
- Cardiovascular Disease and Adiposity
- Cardiac Arrhythmias and Treatments
- Cardiovascular Effects of Exercise
- Cerebrovascular and Carotid Artery Diseases
- Advanced MRI Techniques and Applications
- Cardiovascular Syncope and Autonomic Disorders
- Acute Myocardial Infarction Research
- Congenital heart defects research
- Hormonal Regulation and Hypertension
- Cardiac Structural Anomalies and Repair
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Cardiac pacing and defibrillation studies
- Viral Infections and Immunology Research
- Cardiac electrophysiology and arrhythmias
- Congenital Heart Disease Studies
- Trypanosoma species research and implications
- Infective Endocarditis Diagnosis and Management
University of Naples Federico II
2016-2024
Federico II University Hospital
2015-2024
European Society of Cardiology
2024
Associazione Nazionale Medici Cardiologi Ospedalieri
2024
University of Leeds
2022
University of Colorado Denver
2022
British Heart Foundation
2022
Hypertension Institute
2016-2021
Magna Graecia University
2019
European Society of Hypertension
2018
Background Regression of left ventricular ( LV ) hypertrophy LVH has been a goal in clinical trials. This study tests the external validity results trials on regression using large registry from tertiary care center, to identify phenotypes less likely achieve . Methods and Results Patients Campania Salute Network, free prevalent cardiovascular disease, but with echocardiographic (defined as mass index [LVMi] >47 g/m 2.7 women >50 men) were included. During median follow‐up 67 months,...
In general, women have lower risk for cardiovascular disease. We tested whether this sex-specific protection persists also in the presence of hypertensive left ventricular hypertrophy (LVH).12,329 and men with hypertension free from prevalent disease enrolled prospective Campania Salute Network registry were followed over a median 4.1years. Subjects grouped according to absence or LVH identified by echocardiography using validated cut-off values LV mass index (>47g/m2.7 >50g/m2.7 men). Main...
Background Increased pulse pressure is associated with structural target organ damage, especially in elderly patients, increasing cardiovascular risk. Design In this analysis, we investigated whether high retains a prognostic effect also when common markers of damage are taken into account. Methods We analysed an unselected cohort treated hypertensive patients from the Campania Salute Network registry ( n = 7336). Participants available cardiac and carotid ultrasound were required to be free...
There is little information on left ventricular (LV) hypertrophy (LVH) development during antihypertensive treatment. We evaluate incident LVH in a treated hypertensive cohort, the Campania Salute Network registry. analyzed prospectively 4290 hypertensives (aged 50.3±11.1 years, 40% women) with at least 1-year follow-up, without baseline. Incident was defined as first detection of echocardiographic LV mass index ≥47 women or ≥50 g/m2.7 men. During median 48-month 915 patients (21.3%)...
Myocardial mechano-energetic efficiency (MEE) can be easily approximated by the ratio of stroke work [i.e. SBP times volume (SV)] to a rough estimate energy consumption, 'double product' [SBP heart rate (HR)], which simplified as SV/HR. We evaluated whether MEE is associated with adverse prognosis in relation presence left ventricular hypertrophy (LVH).Hypertensive participants Campania Salute Network (n = 12 353) without prevalent coronary or cerebrovascular disease and ejection fraction...
Aortic root (AR) dimension (ARD) at the Valsalva sinuses has been associated with incident cardiovascular (CV) events in population-based studies, but this effect could be due to association increased left ventricular (LV) mass. There is also uncertainty on how define clear-cut AR dilatation. Thus, we analyzed Campania Salute Network (CSN) registry (i) establish criteria for evaluation of ARD, (ii) propose cut-points dilatation, and (iii) determine whether dilatation prognostic value...
Determinants of changes aortic root dimension over time are not well defined.We investigated whether specific phenotype and treatment exist predicting in hypertensive patients from the Campania Salute Network.N = 4856 participants (age 53 ± 11 years, 44% women) were included. At first last available echocardiograms, we measured a z-score (AOz) was generated as difference between predicted root, derived healthy reference population. Aortic dilatation (ARD) defined AOz >75th percentile...
Fractional flow reserve (FFR) has never been investigated in patients with reduced ejection fraction and associated coronary artery disease (CAD). We evaluated the impact of FFR on management strategies these related outcomes.From 2002 to 2010, all consecutive left ventricular (LVEF) ≤50% undergoing angiography ≥1 intermediate stenosis [diameter (DS)% 50-70%] treated based (Angiography-guided group) or according (FFR-guided were screened for inclusion. In FFR-guided group, 433 matched 866...
Abstract Background Orthostatic hypotension (OH) is a common cardiovascular disorder typically associated with autonomic dysfunction. However, various other mechanisms can contribute to its occurrence. Case summary An 88-year-old woman was referred the cardiology unit due recurrent syncope episodes while standing. Echocardiography revealed normally contracting left ventricle severe hypertrophy, restrictive filling pattern, reduced stroke volume, and decreased inferior vena cava diameter (4...
Hypertrophic cardiomyopathy (HCM) is the most common heritable cardiovascular disorder and characterized by left ventricular hypertrophy (LVH), which unexplained abnormal loading conditions. HCM inherited as an autosomal dominant trait and, in about 40% of patients, causal mutation identified genes encoding sarcomere proteins. According to results genetic screening, patients are currently categorized two main sub-populations: sarcomeric-positive (Sarc+) whom a sarcomeric gene;...
Hypertrophic cardiomyopathy (HCM) is a genetic disease characterized by unexplained left ventricular hypertrophy (LVH), diastolic dysfunction, and increased sudden-death risk. Early detection of the phenotypic expression in carriers without LVH (Gen+/Phen-) crucial for emerging therapies. This clinical study aims to identify echocardiographic predictors development Gen+/Phen-. Sixteen Gen+/Phen- (one subject with troponin T, six myosin heavy chain-7, nine myosin-binding protein C3...
Sex-specific differences in left ventricular (LV) geometry might help developing tailored strategies for hypertension management.
Hypertension is a leading cause of chronic kidney disease (CKD) and decrease in glomerular filtration rate (GFR) associated with higher prevalence hypertension an increased proportion suboptimal blood pressure (BP) control. To investigate characteristics GFR decline, we selected 4539 hypertensive patients from the Campania Salute Network (mean age 53 ± 11 years) at least 3 years follow-up (FU) no more than Stage III CKD. was calculated baseline last available visit using Chronic Kidney...
Abstract BACKGROUND Left atrial (LA) dilatation is associated with unfavorable outcome in hypertension. However, there are few data on clinical, demographic, and echocardiographic findings correlated LA development. METHODS From the Campania-Salute Network registry, we identified 5,375 hypertensive patients (52±11 years, 38% women) normal sinus rhythm, diameter (parasternal short-axis <24.0 women <25.4mm/m men), left ventricular (LV) ejection fraction, at least 12 months of...
Background: Sympathetic dysfunction can be evaluated by heart rate reserve (HRR) with exercise test. Objectives: To determine the value of HRR in predicting outcome patients hypertrophic cardiomyopathy (HCM). Methods: We enrolled 917 HCM (age = 49 ± 15 years, 516 men) assessed stress echocardiography (ESE) 11 centres. ESE modality was semi-supine bicycle 51 (6%), upright 476 (52%), and treadmill 390 (42%). During ESE, we left ventricular outflow tract obstruction (LVOTO), stress-induced new...
Background: Exaggerated variability of blood pressure (BP) poses additional stress on cardiovascular system independent BP average value, increasing risk target organ damage (HMOD) and events. We assessed the impact visit-to-visit (VVV) development events HMOD. Methods: Standard deviation (SD) coefficient mean SBP DBP were calculated in 3555 patients from Campania Salute Network registry, with available echocardiogram more than six visits during follow-up. Values first visit excluded. The...