A5048150819- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Blood Pressure and Hypertension Studies
- Cardiac Valve Diseases and Treatments
- Cardiovascular Health and Disease Prevention
- Cardiovascular Disease and Adiposity
- Cerebrovascular and Carotid Artery Diseases
- Antibiotic Resistance in Bacteria
- Pulmonary Hypertension Research and Treatments
- Infective Endocarditis Diagnosis and Management
- Antibiotics Pharmacokinetics and Efficacy
- COVID-19 Clinical Research Studies
- Atrial Fibrillation Management and Outcomes
- Congenital Anomalies and Fetal Surgery
- Aortic Disease and Treatment Approaches
- Chemotherapy-induced cardiotoxicity and mitigation
- Hormonal Regulation and Hypertension
- Antimicrobial Resistance in Staphylococcus
- Appendicitis Diagnosis and Management
- Intestinal Malrotation and Obstruction Disorders
- Aortic aneurysm repair treatments
- Astronomy and Astrophysical Research
- Coronary Interventions and Diagnostics
- Heart Rate Variability and Autonomic Control
- Lipoproteins and Cardiovascular Health
University of Naples Federico II
1989-2025
Federico II University Hospital
2016-2025
University of California, San Diego
2024
European Space Astronomy Centre
2024
École Normale Supérieure
2024
Sorbonne Université
2024
Université Paris Cité
2024
University of Edinburgh
2021-2024
Vrije Universiteit Brussel
2024
Advanced Pharma
2023
Emerging evidence suggests that elevated circulating levels of HDL-C (high-density lipoprotein cholesterol) could be linked to an increased mortality risk. However, the best our knowledge, relationship between and specific cardiovascular events has never been investigated in patients with hypertension.To fill this knowledge gap, we analyzed hypertensive within Campania Salute Network Southern Italy.We studied 11 987 hypertension, who were followed for 25 534 person-years. Our population was...
2D echocardiography is limited for identifying chemotherapy-related cardiotoxicity. This study compared standard echo, 2D, and 3D speckle tracking (STE) detection of subclinical anthracycline (ANT) cardiotoxicity in breast cancer patients. One-hundred consecutive patients free cardiac symptoms were treated by multiple protocols including ANT cyclophosphamide and/or 5-fluorouracil 3–4 cycles. Both before after treatment, underwent STE-derived left ventricular (LV) global longitudinal strain...
Abstract Background While the augmented incidence of diabetes after COVID-19 has been widely confirmed, controversial results are available on risk developing hypertension during pandemic. Methods We designed a longitudinal cohort study to analyze closed followed up over 7-year period, i.e., 3 years before and pandemic, 2023, when pandemic was declared be over. analyzed medical records more than 200,000 adults obtained from cooperative primary physicians January 1, 2017, December 31, 2023....
Recent advancements in echocardiographic technology allow to analyse myocardial strain multiple layers. Little is known about the impact of age on layer-specific longitudinal healthy subjects. The aim this study was influence multilayer and establish normal reference values according decades a population referring our echo laboratory using 2D speckle-tracking echocardiography with software. Two-hundred sixty-six healthy, consecutive subjects (mean = 39.2 ± 17.5 years, women/men 137/129),...
Abstract Aims This study assessed the impact of strain-guided therapeutic approach on cancer therapy-related cardiac dysfunction (CTRCD) and rate therapy (CT) interruption in breast cancer. Methods results We enrolled 116 consecutive female patients with HER2-positive undergoing a standard protocol by EC (epirubicine + cyclophosphamide) followed paclitaxel trastuzumab (TRZ). Coronary artery, valvular congenital heart disease, failure, primary cardiomyopathies, permanent or persistent atrial...
Objectives Non-contrast CT aortic valve calcium scoring ignores the contribution of valvular fibrosis in stenosis. We assessed calcific and non-calcific disease using contrast-enhanced CT. Methods This was a post hoc analysis 164 patients (median age 71 (IQR 66–77) years, 78% male) with stenosis (41 mild, 89 moderate, 34 severe; 7% bicuspid) who underwent echocardiography as part imaging studies. Calcific (fibrosis) tissue volumes were quantified indexed to annulus area, Hounsfield unit...
Aortic atherosclerosis represents an important contributor to ischemic stroke risk. Identifying patients with high-risk aortic atheroma could improve preventative treatment strategies for future stroke.The purpose of this study was investigate whether thoracic 18F-sodium fluoride positron emission tomography (PET) the identification at highest risk stroke.In a post hoc observational cohort study, we quantified and coronary activity in 461 stable cardiovascular disease undergoing PET combined...
BackgroundThe association of COVID-19 with the development new-onset diabetes has been recently investigated by several groups, yielding controversial results. Population studies currently available in literature are mostly focused on type 1 (T1D), comparing patients a SARS-CoV-2 positive test to individuals without COVID-19, especially paediatric populations. In this study, we sought determine incidence 2 (T2D) before and during pandemic.MethodsIn longitudinal cohort analysed followed up...
Recent studies conducted in COVID-19 survivors suggest that SARS-CoV-2 infection is associated with an increased risk of dyslipidemia. However, it remains unclear whether this augmented confirmed the general population and how phenomenon impacting overall burden cardiometabolic diseases.
Little is known about regional longitudinal strain (LS) distribution in early stages of Anderson-Fabry disease (AFD) cardiomyopathy. We investigated left ventricular (LV) patterns LS and base-to-apex behaviour treatment-naïve AFD patients. Twenty-three consecutive patients at diagnosis 23 healthy controls without cardiovascular risk factors matched for age sex to the patients, underwent a comprehensive evaluation target organs. An echo-Doppler exam, including determination global (GLS) was...
Background The 2018 European Society of Cardiology/European Hypertension arterial hypertension guidelines do not recommend routine carotid ultrasound as a tool to identify hypertension-mediated organ damage, unless clinically indicated. However, plaque (CP) is strong correlate increased stiffness, which influences blood pressure (BP) control over time. Thus, we assessed whether evidence CP at first visit could predict BP during follow-up. Methods and Results From the CSN (Campania Salute...
V-mode polarization of the cosmic microwave background is expected to be vanishingly small in $\Lambda$CDM model and, hence, usually ignored. Nonetheless, several astrophysical effects, as well beyond standard physics could produce it at a detectable level. A realistic half-wave plate - an optical element commonly used CMB experiments modulate polarized signal can provide sensitivity V modes without significantly spoiling that linear polarization. We assess this for some new-generation...
We aimed to investigate the link between LDL cholesterol (LDL-C) levels and hemorrhage risk over an extended period, both in subjects taking aspirin individuals not receiving any antiplatelet agent. calculated predicted adjusted relative hazard of bleeding by LDL-C concentration for whole cohort aspirin-treated subgroup. The study included 39,784 with a mean follow-up 14.9 years, totaling 500,000 patient-years. Across cohort, 3,380 events were reported, higher incidence patients <70mg/dL...
Little is known about the impact of pulse pressure on left ventricular systolic function. The aim our study was to evaluate whether high associated with subclinical dysfunction.The population included 143 participants (68 newly diagnosed, never-treated hypertensive, and 75 normotensive individuals) evaluated by echo-Doppler, including determination global longitudinal strain (GLS) speckle tracking. According tertiles, were divided in two groups: first group merging second tertiles (n = 93,...
Abstract Aims In a hypertensive population with optimal blood pressure control long‐term follow‐up, we aimed at analysing possible predictors of left ventricular (LV) ejection fraction (LVEF) reduction, including indexed mechano‐energetic efficiency (MEEi), well‐recognized echo‐derived parameter LV performance. Methods and results The study included 5673 patients from the Campania Salute Network normal baseline LVEF (≥50%), no prevalent cardiovascular (CV) disease. Patients developing...
An empathetic approach may be particularly useful in patients with therapy-resistant hypertension (TRH), defined as the failure to achieve target blood pressure (BP) despite a maximal doses of 3 antihypertensive drugs including diuretic. However, effects therapeutic concordance have not been determined hypertensive patients.We designed study explore impact TRH, who were included an intervention arm based on protocol which trained personnel periodically verified pharmacological regimen these...