A5011654317- Cardiomyopathy and Myosin Studies
- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Cardiac Valve Diseases and Treatments
- Cardiovascular Effects of Exercise
- Takotsubo Cardiomyopathy and Associated Phenomena
- Cardiac Structural Anomalies and Repair
- Atrial Fibrillation Management and Outcomes
- Infective Endocarditis Diagnosis and Management
- Congenital heart defects research
- Cardiac Arrhythmias and Treatments
- Cardiovascular Disease and Adiposity
- Diet and metabolism studies
- Cardiac electrophysiology and arrhythmias
- Coronary Artery Anomalies
- Bone health and osteoporosis research
- Congenital Heart Disease Studies
- Coronary Interventions and Diagnostics
- Cardiac pacing and defibrillation studies
- Viral Infections and Immunology Research
- Cardiovascular Health and Risk Factors
- Aortic Disease and Treatment Approaches
- Advanced MRI Techniques and Applications
- Antiplatelet Therapy and Cardiovascular Diseases
- Metabolism and Genetic Disorders
Diabetes & Endocrine Associates
2020-2025
New York University
2018-2025
NYU Langone Health
2020-2025
Hinge Health
2023
Albert Einstein College of Medicine
2012-2020
Montefiore Medical Center
2012-2020
University of Edinburgh
2019
Montefiore Health System
2018
Danieli (Italy)
2018
Jacobi Medical Center
2017
In nonobstructive hypertrophic cardiomyopathy (nHCM), there are no approved medical therapies. Impaired myocardial energetics is a potential cause of symptoms and exercise limitation. Ninerafaxstat, novel cardiac mitotrope, enhances energetics. To evaluate the safety efficacy ninerafaxstat in nHCM. Patients with HCM left ventricular (LV) outflow gradient <30 mmHg, ejection fraction ≥50% peak VO2 <80% predicted, were randomized to 200 mg BID or placebo (1:1) for 12 weeks. Primary endpoint was...
Background Disopyramide is used to treat heart failure symptoms in patients with obstructive hypertrophic cardiomyopathy (HCM) known medium‐term efficacy and safety, while long‐term outcomes are unknown. Methods Results A total of 92 consecutive symptomatic HCM peak left ventricular outflow tract gradients ≥30 mm Hg at rest or provocation who were maintained on disopyramide for ≥5 years 2 dedicated centers included: patients; mean age, 62.5 years; 54% women; treated median 7.2 (left wall...
Mitral annular calcification (MAC) is associated with cardiovascular events and mitral valve dysfunction. However, the underlying pathophysiology remains incompletely understood. In this prospective longitudinal study, we used a multimodality approach including positron emission tomography, computed echocardiography to investigate of MAC assess factors disease activity progression.A total 104 patients (age 72±8 years, 30% women) calcific aortic disease, therefore predisposed MAC, underwent...
Objectives Non-contrast CT aortic valve calcium scoring ignores the contribution of valvular fibrosis in stenosis. We assessed calcific and non-calcific disease using contrast-enhanced CT. Methods This was a post hoc analysis 164 patients (median age 71 (IQR 66–77) years, 78% male) with stenosis (41 mild, 89 moderate, 34 severe; 7% bicuspid) who underwent echocardiography as part imaging studies. Calcific (fibrosis) tissue volumes were quantified indexed to annulus area, Hounsfield unit...
Background Hypertrophic cardiomyopathy is defined as unexplained left ventricular ( LV ) hypertrophy (wall thickness ≥15 mm) and prevalent in 0.2% of adults (1:500) population-based studies using echocardiography. Cardiac magnetic resonance imaging MRI allows for more accurate wall measurement across the entire ventricle than The prevalence by cardiac unknown. MESA (Multi-Ethnic Study Atherosclerosis) recruited individuals without overt cardiovascular disease 45 to 84 years age. Methods...
Mitral leaflet elongation is common in hypertrophic cardiomyopathy (HCM), contributes to obstructive physiology, and presents a challenge the dual surgical goals of abolition outflow gradients mitral regurgitation. Anterior shortening, performed as an ancillary procedure during myectomy, controversial.
Background Calcific aortic valve disease (CAVD), and ensuing severe stenosis (AS), is the foremost valvular disorder of aging, yet preventive therapies are lacking. A better understanding molecular underpinnings calcification (AVC) necessary to develop pharmacologic interventions. Methods Results We undertook large‐scale plasma proteomics in a cohort study adults ≥65 years old, CHS (Cardiovascular Health Study), identify individual proteins associated with echocardiographic AVC incident...
Objectives Current estimates of aortic stenosis (AS) frequency have mostly relied on cross-sectional echocardiographic or longitudinal administrative data, making understanding AS burden incomplete. We performed case adjudications to evaluate the and assess differences by age, sex race in an older cohort with long-term follow-up. Methods developed case-capture methods using study echocardiograms, procedure diagnosis codes, heart failure events deaths for targeted review medical records...
The epicardium is a sheet of epithelial cells covering the heart during early cardiac development. In recent years, has been identified as an important contributor to cardiovascular development, and epicardium-derived have potential differentiate into multiple cell lineages. Some that undergo epithelial-to-mesenchymal transition delaminate from surface developing subsequently invade myocardium vascular smooth muscle coronary vasculature. MicroRNAs (miRNAs) implicated broadly in tissue...
OBJECTIVE To investigate the relationship of osteocalcin (OC), a marker bone formation, and C-terminal cross-linked telopeptide type I collagen (CTX), resorption, with incident diabetes in older women. RESEARCH DESIGN AND METHODS The analysis included 1,455 female participants from population-based Cardiovascular Health Study (CHS) (mean [SD] age 74.6 [5.0] years). cross-sectional association serum total OC CTX levels insulin resistance (HOMA-IR) was examined using multiple linear...