A5078662242- Reproductive System and Pregnancy
- Congenital heart defects research
- Pregnancy and preeclampsia studies
- Pluripotent Stem Cells Research
- Cancer Immunotherapy and Biomarkers
- Immune cells in cancer
- Protein Degradation and Inhibitors
- Immune Cell Function and Interaction
- Selenium in Biological Systems
- Blood Coagulation and Thrombosis Mechanisms
- Gastroesophageal reflux and treatments
- Reproductive Health and Contraception
- CRISPR and Genetic Engineering
- Trace Elements in Health
- Parkinson's Disease Mechanisms and Treatments
- Cancer, Hypoxia, and Metabolism
- Systemic Lupus Erythematosus Research
- Preterm Birth and Chorioamnionitis
- Pregnancy and Medication Impact
- Neonatal Respiratory Health Research
- Ectopic Pregnancy Diagnosis and Management
- Congenital Heart Disease Studies
- Moringa oleifera research and applications
- Amoebic Infections and Treatments
- Platelet Disorders and Treatments
University of Pennsylvania
2011-2024
Cardiovascular Institute of the South
2020-2024
Renji Hospital
2017-2024
Shanghai Jiao Tong University
2020-2024
First Hospital of Shanxi Medical University
2024
Shanxi Medical University
2024
Fujian Medical University
2022
Second Affiliated Hospital of Fujian Medical University
2022
California University of Pennsylvania
2022
Second Affiliated Hospital of Zhejiang University
2022
Two niches with distinct characteristics work in tandem.
The plasticity of differentiated cells in adult tissues undergoing repair is an area intense research. Pulmonary alveolar type II produce surfactant and function as progenitors the adult, demonstrating both self-renewal differentiation into gas exchanging I cells. In vivo, are thought to be terminally their ability give rise alternate lineages has not been reported. Here we show that Hopx becomes restricted during development. However, unexpectedly, lineage-labelled Hopx+ proliferate...
Making cardiomyocytes In the heart, multiple cell types work together. Cardiac progenitor cells give rise to cardiomyocyte, endothelial, or smooth muscle lineages. However, identity of a marker specific cardiomyocyte formation has been elusive. Jain et al. now identify specialized population that is committed exclusively forming cardiomyocytes. They also niche signals promote lineage commitment and mechanisms involved in making The findings may help development future cell-based regenerative...
The mammalian hair follicle relies on adult resident stem cells and their progeny to fuel maintain growth throughout the life of an organism. cyclical initially synchronous nature makes ideal system with which define homeostatic mechanisms cell population. Recently, we demonstrated that Hopx is a specific marker intestinal cells. Here, show specifically labels long-lived residing in telogen basal bulge. Hopx(+) contribute all lineages mature interfollicular epidermis upon epidermal wounding....
Background: Gene regulatory networks control tissue homeostasis and disease progression in a cell type–specific manner. Ubiquitously expressed chromatin regulators modulate these networks, yet the mechanisms governing how specificity of their function is achieved are poorly understood. BRD4 (bromodomain-containing protein 4), member BET (bromo- extraterminal domain) family ubiquitously acetyl-lysine reader proteins, plays pivotal role as coactivator enhancer signaling across diverse types...
The relationship between erythropoiesis-stimulating agents (ESAs) and malignant neoplasms (MNs) has been controversial in previous studies. Our study aimed to explore the correlation ESAs MNs. Drug-target Mendelian randomization (MR) analyses were conducted evaluate causal associations of for 12 classifications Meanwhile, a pharmacovigilance was performed by extracting adverse events (AEs) FDA Adverse Event Reporting System (FAERS) database validate complement our findings. MR analysis...
Cardiac differentiation of human-induced pluripotent stem (hiPS) cells consistently produces a mixed population cardiomyocytes and non-cardiac cell types, even when using well-characterized protocols. We sought to determine whether different types might result from intrinsic differences in hiPS prior the onset differentiation.
Exosomes released from decidual stromal cells (DSC-exos) play a crucial role in facilitating the epithelial-mesenchymal transition (EMT) of trophoblasts and insufficient EMT are associated with URSA (unexplained recurrent spontaneous abortion). However, mechanisms underlying DSC-exos inducing is not completely understood. normal pregnant women (N-DSC-exos) patients (URSA-DSC-exos) were extracted characterized. Characterization isolated was performed using TEM (transmission electron...
Myeloid-derived suppressor cells (MDSC), especially polymorphonuclear MDSC (PMN-MDSC), accumulate in maternal-fetal interface during pregnancy and are involved the maintenance of immune tolerance. Decreased PMN-MDSC is associated with complications such as unexplained recurrent loss (URPL). In present study we showed decreased URPL group compared normal (NP) group, was major subset human decidua potent suppression activity. We then performed gene expression profile found that decidual NP...
Abstract Objective Assessment of the prevalence anti‐phosphatidylserine‐prothrombin antibodies (aPS/PT) with OAPS and SN‐OAPS in Chinese patients. Methods This retrospective study proceeded at Ren Ji Hospital, Shanghai, China, from January 2019 to 2020. Two hundred eleven OAPS, 68 SN‐OAPS, 81 disease controls, 30 healthy donors were enrolled. IgM IgG aPS/PT, IgM/IgG ‐ aCL, IgM/ IgG/ anti‐β2GPI tested by ELISA while LAC was clotting assays. All patients followed up least twice over 12 weeks...
Originating as a single vessel emerging from the embryonic heart, truncus arteriosus must septate and remodel into aorta pulmonary artery to support postnatal life. Defective remodeling or septation leads abnormalities collectively known conotruncal defects, which are associated with significant mortality morbidity. Multiple populations of cells interact coordinate outflow tract remodeling, cardiac neural crest has emerged particularly important during this process. Abnormalities in have...
This study aimed to evaluate the role of clinical pharmacist in rational use proton pump inhibitors (PPIs) a general surgery department. All enrolled patients had attended department tertiary hospital. single-center prospective compared differences overall rate PPI use, proportion unindicated utilization rate, average defined daily dose (DDD), drug costs, and cost-effectiveness intervention between (538 cases) control (536 groups. In group, Pareto fishbone diagram analyses were combined with...