Valur Emilsson
A5071985087- Genetic Associations and Epidemiology
- Bioinformatics and Genomic Networks
- Alzheimer's disease research and treatments
- Adipose Tissue and Metabolism
- Regulation of Appetite and Obesity
- Advanced Proteomics Techniques and Applications
- Biochemical Analysis and Sensing Techniques
- Pancreatic function and diabetes
- Genetics and Neurodevelopmental Disorders
- Nutrition, Genetics, and Disease
- Epigenetics and DNA Methylation
- Lipoproteins and Cardiovascular Health
- RNA modifications and cancer
- RNA and protein synthesis mechanisms
- SARS-CoV-2 and COVID-19 Research
- Metabolomics and Mass Spectrometry Studies
- COVID-19 Clinical Research Studies
- Genetic Mapping and Diversity in Plants and Animals
- Genomics and Phylogenetic Studies
- Liver Disease Diagnosis and Treatment
- Birth, Development, and Health
- Metabolism, Diabetes, and Cancer
- Mitochondrial Function and Pathology
- Adipokines, Inflammation, and Metabolic Diseases
- Atherosclerosis and Cardiovascular Diseases
Icelandic Heart Association
2016-2025
University of Iceland
2015-2024
Boston University
2018
Erasmus MC
2018
Framingham Heart Study
2018
Institute for Neurodegenerative Disorders
2018
The University of Texas Health Science Center at San Antonio
2018
University of Split
2016
University of Groningen
2015
Merck & Co., Inc., Rahway, NJ, USA (United States)
2009-2012
The blood proteome in disease Understanding the function of human serum proteins has been limited by difficulties monitoring their production, accumulation, and distribution. Emilsson et al. investigated more than 5000 Icelanders over age 65. composition includes a complex regulatory network that are globally coordinated across most or all tissues. authors identified modules functional groups associated with health outcomes were able to link genetic variants diseases. Science , this issue p. 769
Leptin, encoded for by the mouse ob gene, regulates feeding behavior and energy metabolism. Its receptor (Ob-R) is diabetic (db) gene mutated in db/db so that it lacks cytoplasmic domain. We show full-length leptin (Ob-Rb), which believed to transmit signal, expressed pancreatic islets of ob/ob wild-type mice, as well hypothalamus, liver, kidney, spleen, heart. Recombinant inhibited basal insulin release perfused pancreas preparation from mice but not Zucker fa/fa rats. Leptin (1–100 nmol/l)...
Abstract We conduct a genome-wide association study (GWAS) of educational attainment (EA) in sample ~3 million individuals and identify 3,952 approximately uncorrelated genome-wide-significant single-nucleotide polymorphisms (SNPs). A polygenic predictor, or index (PGI), explains 12–16% EA variance contributes to risk prediction for ten diseases. Direct effects (i.e., controlling parental PGIs) explain roughly half the PGI’s magnitude with other phenotypes. The correlation between mate-pair...
Abstract Background Late‐onset Alzheimer's disease (AD) is heritable with 20 genes showing genome‐wide association in the International Genomics of Project (IGAP). To identify biology underlying disease, we extended these genetic data a pathway analysis. Methods The ALIGATOR and GSEA algorithms were used IGAP to associated functional pathways correlated gene expression networks human brain. Results identified an excess curated biological enrichment association. Enriched areas included immune...
Abstract With the growing number of genetic association studies, genotype-phenotype atlas has become increasingly more complex, yet functional consequences most disease associated alleles is not understood. The measurement protein level variation in solid tissues and biofluids integrated with variants offers a path to deeper insights. Here we present large-scale proteogenomic study 5,368 individuals, revealing 4,035 independent associations between 2,091 serum proteins, which 36% are...
Alzheimer’s disease (AD) is currently defined by the aggregation of amyloid-β (Aβ) and tau proteins in brain. Although biofluid biomarkers are available to measure Aβ pathology, few markers complex pathophysiology that associated with these two cardinal neuropathologies. Here, we characterized proteomic landscape cerebrospinal fluid (CSF) changes pathology 300 individuals using different technologies—tandem mass tag spectrometry SomaScan. Integration both data types allowed for generation a...
The adipocyte hormone leptin activates signal transducer and activator of transcription 3 (STAT3) in the hypothalamus, mediating increased satiety energy expenditure. To date, leptin-mediated activation STAT pathway vivo has not been established tissues other than hypothalamus. We now describe receptor expression signaling discrete regions mouse gastrointestinal tract. Expression functional isoform (OB-Rb) is restricted to jejunum readily detected by RT-PCR isolated enterocytes from this...