Alexey Vedernikov
A5078757494- Genetic Associations and Epidemiology
- Parkinson's Disease Mechanisms and Treatments
- Bioinformatics and Genomic Networks
- Nuclear Receptors and Signaling
- Genetics and Neurodevelopmental Disorders
- T-cell and B-cell Immunology
- Neurological diseases and metabolism
- MicroRNA in disease regulation
- Alzheimer's disease research and treatments
- Bipolar Disorder and Treatment
- Tryptophan and brain disorders
- Immune responses and vaccinations
- Immunotherapy and Immune Responses
- Pharmaceutical studies and practices
- Nutrition, Genetics, and Disease
- Health, Environment, Cognitive Aging
- Fungal and yeast genetics research
- Silk-based biomaterials and applications
- Occupational exposure and asthma
- RNA modifications and cancer
- Food Allergy and Anaphylaxis Research
- Digestive system and related health
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Science, Research, and Medicine
- Parathyroid Disorders and Treatments
Clinical Hospital No. 8
2024
Cardiff University
2012-2016
Medical Research Council
2013-2015
Monash University
2015
Chemical Pharmaceutical Research Institute
1980
Vavilov Institute of General Genetics
1977
Russian Academy of Sciences
1974
Background Alzheimer's disease is a common debilitating dementia with known heritability, for which 20 late onset susceptibility loci have been identified, but more remain to be discovered. This study sought identify new genes, using an alternative gene-wide analytical approach tests patterns of association within in the powerful genome-wide dataset International Genomics Project Consortium, comprising over 7 m genotypes from 25,580 cases and 48,466 controls. Principal Findings In addition...
Abstract Background Late‐onset Alzheimer's disease (AD) is heritable with 20 genes showing genome‐wide association in the International Genomics of Project (IGAP). To identify biology underlying disease, we extended these genetic data a pathway analysis. Methods The ALIGATOR and GSEA algorithms were used IGAP to associated functional pathways correlated gene expression networks human brain. Results identified an excess curated biological enrichment association. Enriched areas included immune...
Neuroticism is a personality trait of fundamental importance for psychological wellbeing and public health. It strongly associated with major depressive disorder (MDD) several other psychiatric conditions. Although neuroticism heritable, attempts to identify the alleles involved in previous studies have been limited by relatively small sample sizes heterogeneity measurement neuroticism. Here we report genome-wide association study 91,370 participants UK Biobank cohort combined meta-analysis...
Progress in instrumental diagnostics, as well increased awareness among doctors about rare diseases, is steadily leading to an number of patients diagnosed with cardiac amyloidosis. Regardless amyloid formation route, damage the main cause mortality systemic The article presents a unique clinical observation hereditary transthyretin (ATTR) amyloidosis mixed phenotype detection during skeletal scintigraphy. In patient severe shortness breath, based on results radiological research,...
In the last two years, nine new susceptibility genes for Alzheimer's disease (AD) have been identified. These findings increased our understanding of and highlighted biological pathways. However these novel AD genes, plus APOE only account approximately a third predicted genetic risk. Therefore large part component is still to be determined.miRNAs are class non-coding which thought an important element post-translational machinery. Abnormalities in miRNA expression mediated gene regulation...