Solveig K. Sieberts
A5048701330- Bioinformatics and Genomic Networks
- Genetic Associations and Epidemiology
- Gene expression and cancer classification
- Genetic Mapping and Diversity in Plants and Animals
- Epigenetics and DNA Methylation
- RNA Research and Splicing
- Neurological disorders and treatments
- Alzheimer's disease research and treatments
- Genetics, Bioinformatics, and Biomedical Research
- Parkinson's Disease Mechanisms and Treatments
- Genetic Syndromes and Imprinting
- Computational Drug Discovery Methods
- Voice and Speech Disorders
- Single-cell and spatial transcriptomics
- RNA modifications and cancer
- Genomics and Rare Diseases
- Cancer-related molecular mechanisms research
- Diet and metabolism studies
- Health, Environment, Cognitive Aging
- Genomic variations and chromosomal abnormalities
- Genetics and Neurodevelopmental Disorders
- Respiratory and Cough-Related Research
- Eating Disorders and Behaviors
- Neuroinflammation and Neurodegeneration Mechanisms
- Genetic and phenotypic traits in livestock
Sage Bionetworks
2013-2024
Center for Systems Biology
2019
Duke University Hospital
2013
University of Washington
2002-2013
Inserm
2013
Duke Medical Center
2013
Duke University
2013
Institut Gustave Roussy
2013
Rosetta Stone (United States)
2005-2011
Merck & Co., Inc., Rahway, NJ, USA (United States)
2005-2010
Genes overlap across psychiatric disease Many genome-wide studies have examined genes associated with a range of neuropsychiatric disorders. However, the degree to which genetic underpinnings these diseases differ or is unknown. Gandal et al. performed meta-analyses transcriptomic covering five major disorders and compared cases controls identify coexpressed gene modules. From this, they found that some share global expression patterns. This in polygenic traits may allow for better diagnosis...
Genetic variants that are associated with common human diseases do not lead directly to disease, but instead act on intermediate, molecular phenotypes in turn induce changes higher-order disease traits. Therefore, identifying the vary response DNA and also associate traits has potential provide functional information required only identify validate susceptibility genes affected by DNA, understand networks which such operate how these Toward end, we profiled more than 39,000 transcripts...
Abstract The availability of high-quality RNA-sequencing and genotyping data post-mortem brain collections from consortia such as CommonMind Consortium (CMC) the Accelerating Medicines Partnership for Alzheimer’s Disease (AMP-AD) enable generation a large-scale cis- eQTL meta-analysis. Here we generate cerebral cortical 1433 samples available four cohorts (identifying >4.1 million significant >18,000 genes), well cerebellar 261 874,836 >10,000 genes). We find substantially improved...
Abstract Schizophrenia and bipolar disorder are serious mental illnesses that affect more than 2% of adults. While large-scale genetics studies have identified genomic regions associated with disease risk, less is known about the molecular mechanisms by which risk alleles small effects lead to schizophrenia disorder. In order fill this gap between phenotype, we undertaken a multi-cohort genomics study postmortem brains from controls, individuals Here present public resource functional data...
To map the genetics of gene expression in metabolically relevant tissues and investigate diversity SNPs (eSNPs) multiple from same individual, we collected four approximately 1000 patients undergoing Roux-en-Y gastric bypass (RYGB) clinical traits associated with their weight loss co-morbidities. We then performed high-throughput genotyping profiling carried out a genome-wide association analyses for more than 100,000 representing tissues: liver, omental adipose, subcutaneous stomach....
Discovering drugs that efficiently treat brain diseases has been challenging. Genetic variants modulate the expression of potential drug targets can be utilized to assess efficacy therapeutic interventions. We therefore employed Mendelian Randomization (MR) on gene measured in tissue identify involved neurological and psychiatric diseases. conducted a two-sample MR using cis-acting brain-derived quantitative trait loci (eQTLs) from Accelerating Medicines Partnership for Alzheimer’s Disease...
Rheumatoid arthritis (RA) affects millions world-wide. While anti-TNF treatment is widely used to reduce disease progression, fails in ∼one-third of patients. No biomarker currently exists that identifies non-responders before treatment. A rigorous community-based assessment the utility SNP data for predicting efficacy RA patients was performed context a DREAM Challenge (http://www.synapse.org/RA_Challenge). An open challenge framework enabled comparative evaluation predictions developed by...
Abstract The AD Knowledge Portal (adknowledgeportal.org) is a public data repository that shares and other resources generated by multiple collaborative research programs focused on aging, dementia, Alzheimer's disease (AD). In this article, we highlight how to use the discover download genomic variant transcriptomic from same individuals. First, show web interface browse search for of interest using relevant file annotations. We demonstrate learn more about context surrounding data,...
Abstract Consumer wearables and sensors are a rich source of data about patients’ daily disease symptom burden, particularly in the case movement disorders like Parkinson’s (PD). However, interpreting these complex into so-called digital biomarkers requires complicated analytical approaches, validating sufficient unbiased evaluation methods. Here we describe use crowdsourcing to specifically evaluate benchmark features derived from accelerometer gyroscope two different datasets predict...
Parkinson's disease (PD) is a neurodegenerative disorder associated with motor and non-motor symptoms. Current treatments primarily focus on managing symptom severity such as tremor, bradykinesia, rigidity. However, the progresses, treatment side-effects can emerge on/off periods dyskinesia. The objective of Levodopa Response Study was to identify whether wearable sensor data be used objectively quantify in individuals PD exhibiting fluctuations. Thirty-one subjects were recruited from 2...
The inability to identify the molecular causes of disease has led a disappointing rate development new medicines.By combining power community-based modeling with broad access large datasets on platform that promotes reproducible analyses, we can work toward more predictive maps deliver better therapeutics. A understanding is neededDrugs continue fail in clinical at startlingly high despite unprecedented amounts investment research and development, largely as result lack efficacy phase 2...
ABSTRACT Over 100 genetic loci harbor schizophrenia associated variants, yet how these common variants confer risk is uncertain. The CommonMind Consortium has sequenced dorsolateral prefrontal cortex RNA from cases (n=258) and control subjects (n=279), creating the largest publicly available resource to date of gene expression its regulation; ∼5 times larger than latest release GTEx. Using this resource, we find that ∼20% have could explain regulation brain expression. In five loci, modulate...