A5049946675- Asymmetric Synthesis and Catalysis
- Chemical Synthesis and Analysis
- Coordination Chemistry and Organometallics
- Systemic Lupus Erythematosus Research
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Osteoarthritis Treatment and Mechanisms
- Organoboron and organosilicon chemistry
- Synthetic Organic Chemistry Methods
- Rheumatoid Arthritis Research and Therapies
- Mathematical Analysis and Transform Methods
- Spectral Theory in Mathematical Physics
- Monoclonal and Polyclonal Antibodies Research
- Cytokine Signaling Pathways and Interactions
- Catalytic Cross-Coupling Reactions
- Genetic Associations and Epidemiology
- Atherosclerosis and Cardiovascular Diseases
- Inflammatory mediators and NSAID effects
- Advanced Synthetic Organic Chemistry
- Advanced Operator Algebra Research
- Cell Adhesion Molecules Research
- Analytical Chemistry and Chromatography
- Chemical synthesis and alkaloids
- Attention Deficit Hyperactivity Disorder
- Asymmetric Hydrogenation and Catalysis
Universidade de Santiago de Compostela
2009-2021
Instituto de Investigación Sanitaria de Santiago
2011-2021
Xunta de Galicia
2021
Center for Research in Molecular Medicine and Chronic Diseases
2016-2020
Complejo Hospitalario Universitario de Santiago
2007-2017
Universidad de Zaragoza
2009-2016
Servicio Gallego de Salud
2016
Fundación Pública Galega de Medicina Xenómica
2016
Instituto de Síntesis Química y Catálisis Homogénea
2011-2016
University of Alabama at Birmingham
2016
Abstract The effectiveness of most cancer targeted therapies is short-lived. Tumors often develop resistance that might be overcome with drug combinations. However, the number possible combinations vast, necessitating data-driven approaches to find optimal patient-specific treatments. Here we report AstraZeneca’s large combination dataset, consisting 11,576 experiments from 910 across 85 molecularly characterized cell lines, and results a DREAM Challenge evaluate computational strategies for...
Abstract Introduction We aimed to replicate association of newly identified systemic lupus erythematosus (SLE) loci. Methods selected the most associated SNP in 10 SLE These SNPs were analysed 1,579 patients with and 1,726 controls European origin by single-base extension. Comparison allele frequencies between cases was done Mantel–Haenszel approach account for heterogeneity sample collections. Results A previously controversial a TYK2 gene replicated (odds ratio (OR) = 0.79, P 2.5 × 10- 5...
[reaction: see text] Allylic substitution reactions of zinc-copper organometallics on (Z)-allylic pentafluorobenzoates proceed with very high regioselectivity and excellent anti selectivity. The fidelity in transfer stereochemical information allowed a short synthesis (+)-ibuprofen (97% ee).
This review describes available methods for the diastereoselective and asymmetric synthesis of quaternary prolines. The focus is on preparation alpha-functionalized prolines with pyrrolidine moiety not embedded in a polycyclic frame. diverse synthetic approaches are classified according to bond which formed complete skeleton.
Rheumatoid arthritis (RA) affects millions world-wide. While anti-TNF treatment is widely used to reduce disease progression, fails in ∼one-third of patients. No biomarker currently exists that identifies non-responders before treatment. A rigorous community-based assessment the utility SNP data for predicting efficacy RA patients was performed context a DREAM Challenge (http://www.synapse.org/RA_Challenge). An open challenge framework enabled comparative evaluation predictions developed by...
Nesfatin-1, a satiety-inducing peptide identified in hypothalamic regions that regulate energy balance, is an integral regulator of homeostasis and putative glucose-dependent insulin coadjuvant. We investigated its production by human cardiomyocytes effects on glucose uptake, the main cardiac transporter GLUT-4 intracellular signaling. Quantitative RT-PCR, Western blots, confocal immunofluorescence microscopy, ELISA murine and/or tissue showed can synthesize secrete nesfatin-1. Confocal...
Assessment of gene expression is an important component osteoarthritis (OA) research, greatly improved by the development quantitative real-time PCR (qPCR). This technique requires normalization for precise results, yet no suitable reference genes have been identified in human articular cartilage. We examined ten well-known to determine most adequate this application. Analyses stability cartilage from 10 patients with hip OA, 8 knee OA and controls without were done classical statistical...
The turbot (Scophthalmus maximus; Scophthalmidae; Pleuronectiformes) is a flatfish species of great relevance for marine aquaculture in Europe. In contrast to other cultured flatfish, very few genomic resources are available this species. Aeromonas salmonicida and Philasterides dicentrarchi two pathogens that affect culture causing serious economic losses the industry. Little known about molecular mechanisms disease resistance host-pathogen interactions work, thousands ESTs functional...
Genome-wide association studies of rheumatoid arthritis (RA) have identified an the disease with a 6q23 region devoid genes. TNFAIP3, RA candidate gene, flanks this region, and polymorphisms in both TNFAIP3 gene intergenic are associated systemic lupus erythematosus. We hypothesized that there is similar RA, including region.To test hypothesis, we selected tag-single nucleotide (SNPs) loci. They were analyzed 1,651 patients 1,619 control individuals Spanish ancestry.Weak evidence was found...
Abstract Objective Rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) share some genetic factors such as HLA , PTPN22 STAT4 6q23 . The aim of this study was to determine whether 9 other SLE are also implicated in RA susceptibility. Methods A characteristic single‐nucleotide polymorphism (SNP) each factors, ITGAM (rs1143679), C8orf13–BLK (rs13277113), TYK2 (rs2304256), 1q25.1 (rs10798269), PXK (rs6445975), KIAA1542 (rs4963128), MECP2 (rs17435), BANK1 (rs17266594), LY9...
Background Heart failure (HF) involves alterations in metabolism, but little is known about cardiomyopathy-(CM)-specific or diabetes-independent gene expression of proteins involved fatty-acid (FA) uptake and oxidation calcium-(Ca2+)-handling the human heart. Methods RT-qPCR was used to quantify mRNA immunoblotting confirm protein left-ventricular myocardium from patients with HF (n = 36) without diabetes mellitus ischaemic (ICM, n 16) dilated (DCM, 20) cardiomyopathy aetiology, non-diseased...
Functionalized allylic electrophilic reagents such as chiral 2-iodo-1-cyclohexenyl and -cyclopentenyl phosphates undergo highly stereoselective anti-SN2'-allylic substitution reactions with a wide range of organozinc (R2Zn RZnI) leading to products transfer the information >95%. The use functionalized iodides allows preparation bicyclic enones 8 9 in ≥93% ee.
To examine genetic association between rheumatoid arthritis (RA) and known polymorphisms in core genes of the nuclear factor (NF)kappaB pathway, major intracellular pathway RA pathogenesis.Discovery replication sample sets Spanish patients with controls were studied. A total 181 single nucleotide (SNPs) uniformly spaced along genomic sequences 17 NFkappaB (REL, RELA, RELB, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, IKBKA, IKBKB, IKBKE, IKBKAP, KBRAS1, KBRAS2, MAP3K1, MAP3K14, TAX1BP1) studied by...
Objectives: Decreased levels of transforming growth factor beta (TGFβ) have been related to the failure cartilage repair in experimental models osteoarthritis. This study aimed examine this aspect osteoarthritis human cartilage. Methods: Cartilage samples were obtained from 11 patients with hip and femoral neck fracture who undergoing total replacement. Gene expression three TGFβ isoforms, collagen type II (COL2A1) aggrecan (AGC1) was analysed by reverse transcription quantitative PCR...
Objective.To confirm that the presence of anticitrullinated ␣-enolase peptide 1 (anti-CEP-1) antibodies identifies a subgroup patients with rheumatoid arthritis (RA).Methods.DNA and serum samples were obtained from 451 RA 279 healthy control subjects, all whom Spanish ancestry.Antibodies to cyclic citrullinated (CCP) CEP-1 measured by enzyme-linked immunosorbent assay.HLA-DRB1 R620W single-nucleotide polymorphism PTPN22 genotyped.Results.Anti-CEP-1 anti-CCP observed in 26.8% 71.2% RA,...
We aimed to replicate the strong associations that a recent genome wide association study (GWAS) has found between 16 single nucleotide polymorphisms (SNPs) and response anti-tumour necrosis factor (TNF) treatment in 89 patients with rheumatoid arthritis (RA). This is very important because, according published simulations, as reported ones will mean these SNPs could be used predictors of at individual level. Disease activity score (DAS28) was evaluated 151 anti-TNF treated RA Spanish...
Abstract An overview of the synthetic methods developed to build all cis ‐fused stereoisomers octahydroindole‐2‐carboxylic acid and its α‐methylated derivative in enantiomerically pure form is presented. Both asymmetric strategies(auxiliary‐ or substrate‐controlled processes) procedures based on resolution racemic compounds (chemical, enzymatic, chromatographic are summarized. Special emphasis has been placed those strategies able provide multigram quantities enantiopure compounds, a...