A5101745422- Organic Electronics and Photovoltaics
- Conducting polymers and applications
- Perovskite Materials and Applications
- Plant and animal studies
- Molecular Junctions and Nanostructures
- Insect-Plant Interactions and Control
- Forest Insect Ecology and Management
- Plant biochemistry and biosynthesis
- Bioinformatics and Genomic Networks
- Genomics and Phylogenetic Studies
- Insect and Pesticide Research
- Plant nutrient uptake and metabolism
- Organic Light-Emitting Diodes Research
- Advanced Radiotherapy Techniques
- Gene Regulatory Network Analysis
- Autophagy in Disease and Therapy
- Quantum Dots Synthesis And Properties
- Microbial Natural Products and Biosynthesis
- scientometrics and bibliometrics research
- Hepatitis Viruses Studies and Epidemiology
- Fullerene Chemistry and Applications
- bioluminescence and chemiluminescence research
- Protein Degradation and Inhibitors
- Computational Drug Discovery Methods
- Cell Image Analysis Techniques
Gregor Mendel Institute of Molecular Plant Biology
2022-2025
Korea Advanced Institute of Science and Technology
2008-2025
Austrian Academy of Sciences
2023-2024
Seoul National University
2008-2024
Korea Forest Service
2023
Korea National Arboretum
2023
Yonsei University
2020
National Cancer Institute
2019
National Institutes of Health
2019
Korean Institute of Criminology
2019
Abstract The effectiveness of most cancer targeted therapies is short-lived. Tumors often develop resistance that might be overcome with drug combinations. However, the number possible combinations vast, necessitating data-driven approaches to find optimal patient-specific treatments. Here we report AstraZeneca’s large combination dataset, consisting 11,576 experiments from 910 across 85 molecularly characterized cell lines, and results a DREAM Challenge evaluate computational strategies for...
State-space analysis of the p53 network identifies a therapeutic strategy for treating cancer.
Summary Plants, as a sessile organism, produce various secondary metabolites to interact with the environment. These chemicals have fascinated plant science community because of their ecological significance and notable biological activity. However, predicting complete biosynthetic pathways from target molecules metabolic building blocks remains challenge. Here, we propose retrieval‐augmented dual‐view retrosynthesis (READRetro) practical bio‐retrosynthesis tool predict natural products....
Some plant RNA viruses in the family Betaflexiviridae encode a nucleic acid-binding protein (NABP) that facilitates infection by suppressing host silencing response. Previously, no members of genus Tepovirus within this were known to possess NABP homolog. In study, we identified genome sequences 21 novel viruses: 17 represent new , and four may be founding closely related Vitivirus . Notably, five these newly tepoviruses contain NABP-like open reading frame (ORF). Sequence comparison...
Abstract The plant cell wall not only serves as a physical barrier against pathogens but, when damaged, also functions source of wall-derived molecules that play crucial roles in immunity damage-associated molecular patterns (DAMPs). While oligogalacturonides from homogalacturonan are well-studied DAMPs, the immune-signaling potential other components remains largely unexplored. Conventional genetic and biochemical approaches aimed at identifying ligand-receptor pairs have been limited by...
The major floral scent compounds of Arabidopsis thaliana flowers are terpenes. Although A. is generally considered to be a self-pollinating plant, there natural variation in terpene volatile emission from flowers. However, the genetic mechanisms underlying scents remain limited. Here, we screened 116 accessions and observed substantial variability levels across these accessions. A genome-wide association study (GWAS) uncovered genomic region associated with myrcene, one monoterpene...
We report an efficient method to adjust the compositions of CH<sub>3</sub>NH<sub>3</sub>PbI<sub>3</sub> perovskite by controlling working pressure CH<sub>3</sub>NH<sub>3</sub>I and its effects on films in a vacuum co-deposition process.
The co-regulation of transcription factors (TFs) has been widely observed in various species. Why is such a mechanism needed for transcriptional regulation? To answer this question, the following experiments and analyses were performed. First, examination human gene regulatory network (GRN) indicated that was significantly enriched GRN. Second, mathematical simulation an artificial showed related to biphasic dose-response patterns TFs. Third, relationship between pattern confirmed using...
Two novel electron-donor molecules based on donor−π-conjugated linker–acceptor structure with compact packing and intramolecular charge-transfer characteristics were synthesized for the preparation of efficient organic solar cells. The donor featuring an electron-rich triphenyl amine as unit, dicyanovinylene acceptor π-conjugated linkers thienothiophene, thiophene, thiazole units synthesized. carefully designed to have a planar structure, conjugation length, appropriate energy levels in...
Inverted near-infrared (NIR) organic photodetectors (OPDs) are required to combine the OPDs with an n-channel silicon-based integrated circuit. NIR absorption in 930–960 nm range is important because intensity of solar irradiation low this wavelength regime. Here, we controlled crystallinity lead(II) phthalocyanine (PbPc) a PbPc:C60 blend film obtain absorption. To form triclinic phase responsible for light absorption, substrate was heated during fabrication and C60 used as templating layer,...
We developed an automatic method to segment cardiac substructures given a radiotherapy planning CT images support epidemiological studies or clinical trials looking at disease endpoints after radiotherapy.We used most-similar atlas selection algorithm and 3D deformation combined with 30 detailed atlases. cross-validated our within the library by evaluating geometric comparison metrics comparing doses for simulated breast between manual contours. analyzed impact of number in use guide points...
Receptor kinase (RK) families process information from small molecules, short peptides, or glycan ligands to regulate core cellular pathways in plants. To date, whether individual plant RKs are capable of processing signals distinct types remains largely unexplored. Addressing this requires the discovery structurally unrelated that engage same receptor. Here, we focus on FLAGELLIN-SENSING 2 (FLS2), an RK senses a peptide bacterial flagellin activate antibacterial immunity Arabidopsis. We...
The molecular orientation and crystallinity of donor acceptor molecules are important for high-efficiency organic photovoltaic cells (OPVs) because they significantly influence both the absorption light charge-transport characteristics. We report that templating effect extends to multilayers increase modify crystals lead phthalocyanine (PbPc) C70 layers at same time by adopting CuBr as a new layer on indium tin oxide (ITO). formation monoclinic phase with preferred (320) PbPc fcc (220) is...
Autophagy serves as an important recycling route for the growth and survival of eukaryotic organisms in nutrient-deficient conditions. Since starvation induces massive changes metabolic flux that are coordinated by key enzymes, specific processing steps autophagy may be linked with flux-monitoring enzymes. We attempted to identify carbon genes modulate using VIGS screening 45 glycolysis- Calvin-Benson cycle-related Arabidopsis (Arabidopsis thaliana). Here, we report three consecutive...
Abstract Background Preingestive behavioral modulations of herbivorous insects on the host plant are abundant over insect taxa. Those behaviors suspected to have functions such as deactivation defenses, nutrient accumulation, or modulating plant-mediated herbivore interactions. To understand functional consequence modulation herbivore, we studied girdling behavior Phytoecia rufiventris Gautier (Lamiinae; Cerambycidae) its Erigeron annuus L. (Asteraceae) that is performed before endophytic...
The templating effect of copper halogen compounds on the growth lead phthalocyanine was described by heteroepitaxial organic molecules layers.
Abstract Motivation: Viewing a cellular system as collection of interacting parts can lead to new insights into the complex behavior. In this study, we have investigated aryl hydrocarbon receptor (AhR) signal transduction pathway from such system-level perspective. AhR detects various xenobiotics, drugs or endocrine disruptors (e.g. dioxin), and mediates transcriptional regulation target genes those in cytochrome P450 (CYP450) family. On binding with 2,3,7,8-tetrachlorodibenzo-p-dioxin...
DW2008 is an anhydrous ethanol extract of Justicia procumbens produced by Dong-Wha Pharmaceutical, Inc., Co. as a candidate anti-asthmatic drug. In this study, selectively reduced T helper 2 (Th2) cytokines in mouse splenocytes and ameliorated ovalbumin-induced airway inflammation downregulating pulmonary infiltration differential inflammatory cells Th2 more than decoction or J. did asthma model. also significantly inhibited hyperresponsiveness the thickness epithelium. HPLC analysis showed...
We report that the crystallinity of C70 is improved significantly if CuI used as a templating layer, leading to remarkable enhancement hole mobilities from 8.32 × 10(-6) 3.26 10(-5) cm(2)/(V s). As result, use layer in C70-based solar cells with low donor concentration resulted significant improvement fill factor 0.51 0.57 and power conversion efficiency 5.56% 6.23% under simulated AM 1.5G, 1 sun irradiation. This result demonstrates effective at improving fullerene derivatives well materials.
Background: Many plants compensate for the damage caused by herbivorous insects through tolerance responses.Besides directly causing plant tissue loss and seed production reduction, herbivory causes phenological changes in host plant.However, little is known about fitness costs of responses to attacks.Results: The girdling beetle Phytoecia rufiventris a short-term decrease number flowers Erigeron annuus.However, accelerated growth restored flowers, but after 2-week delay.With an objective...