A5070744146- Constructed Wetlands for Wastewater Treatment
- Microplastics and Plastic Pollution
- Laser-Matter Interactions and Applications
- Pancreatic and Hepatic Oncology Research
- Respiratory viral infections research
- Influenza Virus Research Studies
- Genetic Associations and Epidemiology
- Spectroscopy and Quantum Chemical Studies
- RNA and protein synthesis mechanisms
- COVID-19 diagnosis using AI
- Tryptophan and brain disorders
- Gut microbiota and health
- COVID-19 Clinical Research Studies
- PI3K/AKT/mTOR signaling in cancer
- Video Surveillance and Tracking Methods
- Cold Atom Physics and Bose-Einstein Condensates
- Wastewater Treatment and Nitrogen Removal
- Ubiquitin and proteasome pathways
- Genetics and Neurodevelopmental Disorders
- Nanoparticles: synthesis and applications
- Cancer Genomics and Diagnostics
- Advanced Neural Network Applications
- Astro and Planetary Science
- Epigenetics and DNA Methylation
- Quantum optics and atomic interactions
Xuzhou Medical College
2025
Icahn School of Medicine at Mount Sinai
2018-2024
Inner Mongolia University of Finance and Economics
2024
National Taipei University of Technology
2024
Southeast University
2019-2024
Tianjin University of Technology
2024
Rush University Medical Center
2024
Shenzhen University
2024
University of Rostock
2021-2024
Heilongjiang Bayi Agricultural University
2021-2024
For diagnosis of coronavirus disease 2019 (COVID-19), a SARS-CoV-2 virus-specific reverse transcriptase polymerase chain reaction (RT-PCR) test is routinely used. However, this can take up to 2 d complete, serial testing may be required rule out the possibility false negative results and there currently shortage RT-PCR kits, underscoring urgent need for alternative methods rapid accurate patients with COVID-19. Chest computed tomography (CT) valuable component in evaluation suspected...
Abstract For diagnosis of COVID-19, a SARS-CoV-2 virus-specific reverse transcriptase polymerase chain reaction (RT-PCR) test is routinely used. However, this can take up to two days complete, serial testing may be required rule out the possibility false negative results, and there currently shortage RT-PCR kits, underscoring urgent need for alternative methods rapid accurate COVID-19 patients. Chest computed tomography (CT) valuable component in evaluation patients with suspected infection....
Factors that contribute to enhanced susceptibility severe bacterial disease after influenza virus infection are not well defined but likely include the microbiome of respiratory tract. Vaccination against influenza, while having variable effectiveness, could also play a role in microbial community stability. We collected nasopharyngeal samples from 215 individuals infected with A/H3N2 or B and profiled microbiota by target sequencing 16S rRNA gene. identified signature taxonomic groups...
RNA viruses are a major human health threat. The life cycles of many highly pathogenic like influenza A virus (IAV) and Lassa depends on host mRNA, because viral polymerases cleave 5′-m7G-capped transcripts to prime mRNA synthesis ("cap-snatching"). We hypothesized that start codons within cap-snatched could generate chimeric human-viral mRNAs with coding potential. report the existence this mechanism gene origination, which we named "start-snatching." Depending reading frame,...
Diabetes mellitus is a metabolic disease characterized by elevated blood glucose due to deficiency of insulin secretion and/or action. Long-term poor control may lead chronic damage and dysfunction the heart, kidneys, eyes, other organs. Therefore, it important develop treatments for diabetes its complications. Fingolimod structural sphingosine analogue sphingosine-1-phosphate receptor modulator currently used treatment relapsing-remitting multiple sclerosis. Several studies have shown that...
The specific interactions of Mycobacterium tuberculosis (Mtb), the causative agent (TB), and lung microbiota in infection are entirely unexplored. Studies cancer other infectious diseases suggest that there important exchanges occurring between host influence immunological landscape. This can result alterations immune regulation inflammation both locally systemically. To assess whether Mtb modifies microbiome, identify changes microbial abundance diversity as a function pulmonary...
The YOLOv3 target detection algorithm is widely used in industry due to its high speed and accuracy, but it has some limitations, such as the accuracy degradation of unbalanced datasets. based on a Gaussian fuzzy data augmentation approach pre-process set improve algorithm. Through efficient pre-processing, confidence level generally improved by 0.01-0.02 without changing recognition YOLOv3, processed images also perform better image localization effective feature fusion, which more line...
Driven by the high profit, Portable Executable (PE) malware has been consistently evolving in terms of both volume and sophistication. PE family classification gained great attention a large number approaches have proposed. With rapid development machine learning techniques exciting results they achieved on various tasks, algorithms also popularity task. Three mainstream that use based algorithms, as categorized input format methods take, are image-based, binary-based disassembly-based...
Kirsten rat sarcoma virus (KRAS) mutations are widespread in pancreatic ductal adenocarcinoma (PDAC) and contribute significantly to tumor initiation, progression, relapse/resistance, prognosis of patients. Although inhibitors against KRAS have been developed, this therapeutic approach is not routinely used PDAC We investigated the anti-tumor efficacy two BI-3406 (KRAS::SOS1 inhibitor) sotorasib (KRAS G12C alone or combination with MEK1/2 inhibitor trametinib and/or PI3K buparlisib seven...
The aberrant activation of the phosphoinositide 3-kinase (PI3K)/ protein kinase B (AKT) pathway is common in pancreatic ductal adenocarcinomas (PDAC). application inhibitors against PI3K and AKT has been considered as a therapeutic option. We investigated PDAC cell lines exposed to increasing concentrations MK-2206 (an AKT1/2/3 inhibitor) Buparlisib (a pan-PI3K inhibitor). Cell proliferation, metabolic activity, biomass, apoptosis/necrosis were evaluated. Further, whole-exome sequencing...
Microglia are resident immune cells of the brain and implicated in etiology Alzheimer's Disease (AD) other diseases. Yet cellular molecular processes regulating their function throughout course disease poorly understood. Here, we present transcriptional landscape primary microglia from 189 human postmortem brains, including 58 healthy aging individuals 131 with a range phenotypes, 63 patients representing full spectrum clinical pathological severity AD. We identified changes associated...