A5046569738- Physics of Superconductivity and Magnetism
- Advanced Condensed Matter Physics
- Magnetic and transport properties of perovskites and related materials
- Liquid Crystal Research Advancements
- High-pressure geophysics and materials
- GaN-based semiconductor devices and materials
- Computational Drug Discovery Methods
- Optical Polarization and Ellipsometry
- Inorganic Fluorides and Related Compounds
- Superconducting Materials and Applications
- Solid-state spectroscopy and crystallography
- Spectroscopy Techniques in Biomedical and Chemical Research
- Electronic and Structural Properties of Oxides
- Protein Structure and Dynamics
- Spectroscopy and Quantum Chemical Studies
- Textile materials and evaluations
- Force Microscopy Techniques and Applications
- Photoreceptor and optogenetics research
- Multiferroics and related materials
- Semiconductor Quantum Structures and Devices
- Advanced Optical Imaging Technologies
- Color Science and Applications
- Metal-Catalyzed Oxygenation Mechanisms
- Dyeing and Modifying Textile Fibers
- Adhesion, Friction, and Surface Interactions
University of Rostock
2021-2025
OSRAM (Germany)
2016-2024
OSRAM (United States)
2023
Universitätsmedizin Rostock
2021
Max Planck Institute for Dynamics and Self-Organization
2011-2016
Universität Hamburg
2002-2014
Max Planck Society
2011-2014
Center for Free-Electron Laser Science
2008-2010
Chemnitz University of Technology
2010
The calculation of hydrogen positions is a common preprocessing step when working with crystal structures protein-ligand complexes. An explicit description atoms generally needed in order to analyze the binding mode particular ligands or calculate associated energies. Due large number degrees freedom resulting from different chemical moieties and high degree mutual dependence this problem anything but trivial. In addition an efficient algorithm take care complexity complicated bonding...
Orbital ordering leads to an unconventional excitation spectrum that we investigate by resonance Raman scattering using incident photon energies between 1.7 and 5.0 eV. We use spectral ellipsometry determine the corresponding dielectric function. Our results show resonant behavior of phonon cross section when laser frequency is close orbiton-excitation energy 2 eV in LaMnO3. excellent agreement theoretical calculations based on Franck-Condon mechanism activating multiphonon first order...
The electronic response of doped manganites at the transition from paramagnetic insulating to ferromagnetic metallic state in ${\text{La}}_{1\ensuremath{-}x}{\text{Ca}}_{x}{\text{MnO}}_{3}$ for $x=0.3$ and 0.2 was investigated by dc conductivity, ellipsometry, vacuum ultraviolet reflectance energies between 0 22 eV. A stabilized Kramers-Kronig transformation yields optical conductivity reveals changes spectral weight up eV metal-to-insulator transition. In observed energy range, is conserved...
Abstract The generation of sets low‐energy conformations for a given molecule is central task in drug design. Herein we present new conformation generator called CONFECT that builds on our previously published library torsion patterns. Conformations are generated as well ranked by means normalized frequency distributions derived from the Cambridge Structural Database (CSD). Following an incremental construction approach, selected systematic enumeration within energetic boundaries. tool...
Due to late-stage diagnoses and limited treatment options, pancreatic cancer is predicted be the second leading cause of deaths by 2030. Many different murine models were developed over past decades test new therapies for this tumor entity. The laws regulations demand continuous refinement animal experiments in order improve welfare sustainably. A key aspect here definition early humane endpoint criteria avoid severe lasting suffering animals through timely euthanasia. present study analyzed...
Amazingly stable: The bis(guanidine) ligand N1,N3-bis[bis(2,2,6,6-tetramethylpiperidin-1-yl)methylen]propan-1,3-diamine stabilizes the first bis(μ-oxo)dicopper(III) complex (see figure) at room temperature. This is characterized in ground state and optical excited by a combination of EXAFS resonance Raman spectroscopy. Detailed facts importance to specialist readers are published as "Supporting Information". Such documents peer-reviewed, but not copy-edited or typeset. They made available...
An excitation at 201 meV is observed in the doped-hole ladder cuprate ${\mathrm{Sr}}_{14}{\mathrm{Cu}}_{24}{\mathrm{O}}_{41}$, using ultraviolet resonance Raman scattering with incident light 3.7 eV polarized along rungs. The of charge nature, a temperature independent energy, and can be understood via an intraladder pair-breaking process. intensity tracks closely order parameter density wave ${\mathrm{CDW}}_{L}$, but persists above its transition ${T}_{{\mathrm{CDW}}_{L}}$, indicating...
Rationale: Antral peristalsis is responsible for gastric emptying. Its failure called gastroparesis and often caused by dysfunction of enteric neurons interstitial cells Cajal (ICC). Current treatment options, including electrical stimulation, are non-satisfying may improve symptoms but commonly fail to restore Herein, we explore direct optogenetic stimulation smooth muscle (SMC) via the light-gated non-selective cation channel Channelrhodopsin2 (ChR2) control motor function. Methods: We...
Kirsten rat sarcoma virus (KRAS) mutations are widespread in pancreatic ductal adenocarcinoma (PDAC) and contribute significantly to tumor initiation, progression, relapse/resistance, prognosis of patients. Although inhibitors against KRAS have been developed, this therapeutic approach is not routinely used PDAC We investigated the anti-tumor efficacy two BI-3406 (KRAS::SOS1 inhibitor) sotorasib (KRAS G12C alone or combination with MEK1/2 inhibitor trametinib and/or PI3K buparlisib seven...
We study the dynamics of superconducting order parameter in high-${T}_{c}$ cuprate ${\mathrm{Bi}}_{2}{\mathrm{Sr}}_{2}{\mathrm{CaCu}}_{2}{\mathrm{O}}_{8+\ensuremath{\delta}}$ by employing a novel time-resolved pump-probe Raman experiment. find two different coupling mechanisms that contribute equally to pair-breaking peak. One sets very fast at 2 ps and relaxes slowly, while other one is delayed roughly 5 fast. A model couples holes through phonons able reproduce part condensate dynamics;...
Lateral diffusion of three different dye molecules (terrylene and two perylene diimides) in 4 to 225 nm thin films 8CB liquid crystals the smectic-A phase has been investigated on a single molecule level. The influence film thickness tracer can be qualitatively modeled by hydrodynamic approach. Molecular tracking experiments as well fluorescence correlation (FCS) studies reveal presence dynamics which span range at least more than one order magnitude time, is much larger reported anisotropic...
Mesoscopic structures in liquids have an impact on the diffusion dynamics of constituting molecules. Smectic 8CB liquid crystals silicon wafers show formation mesoscopic μm scale at a film thickness 200 nm. Depending kind substrate (thermally grown or native SiOx), we observed focal conic domains (FCDs) and new type terraced holes, respectively. Dynamics are described via single perylene diimide tracer molecule tracking translational case FCDs by combination translation rotation detected...
The profile of menisci freely suspended smectic films is studied by atomic force microscopy and optical interferometry. measured meniscus profiles show two distinct regions: a circular shape in thicker regions an almost linear slope near the edge planar film area. A macroscopic contact angle several degrees found between flat film. In C phase close to transition C, are decorated characteristic stripe pattern that was first described Meyer Pershan [Solid State Commun., 1973, 13, 989–992]. We...
We present the design and performance of a new triple-grating deep ultraviolet to near-infrared spectrometer. The system is fully achromatic due use reflective optics. minimization image aberrations by using on- off- axis parabolic mirrors as well elliptical yields strong stray light rejection with high resolution over wavelength range between 165 1000nm. Raman signal collected entrance objective numerical aperture 0.5, featuring Cassegrain-type design. Resonance studies on semiconductors...
We present a study of the molecular diffusion in freely suspended smectic-A liquid crystal films with thicknesses ranging from 20 down to only two layers. The mobility is directly probed by determining trajectories single, fluorescent tracer molecules. demonstrate, using several different smectic compounds, that monotonic increase coefficient decreasing film thickness general phenomenon. In two-layer films, enhanced factor 3 5 compared corresponding bulk phase. Molecular dynamics simulations...
The fundament of an evidence-based severity assessment in laboratory animal science is reliable distress parameters. Many readouts are used to evaluate and determine the experimental procedures. Therefore, we analyzed four distinct parameters like body weight, burrowing behavior, nesting, score gastrointestinal models (pancreatic ductal adenocarcinoma (PDA), pancreatitis, CCl4 intoxication, bile duct ligation (BDL)). Further, determined parameters' robustness various subgroups due slight...
The homochirality of biomolecules is a prerequisite for the origin and evolution terrestrial life. unique selection D-monosaccharides, in particular, D-ribose RNA D-deoxyribose DNA, leads to construction proteins by L-amino acids. This points exclusive role stereoselectivity most important physiological processes. So far, there no experimental confirmation theoretical calculations energy differences between enantiomers used explanation stereoselection biomolecules. Therefore, question why...
We use resonance Raman scattering (incident photon energies between 1.8 and 4.13 eV), $\text{LDA}+\text{U}$ calculations, spectroscopic ellipsometry, oblique IR reflectivity to characterize the strong electron-phonon interactions in disordered perovskite ${\text{LaFe}}_{0.5}{\text{Cr}}_{0.5}{\text{O}}_{3}$. When energy coincides with a Cr Fe Mott-Hubbard transfer gap around 2.4 eV interaction is manifested by Franck-Condon effect exceptional first- higher order of local oxygen breathing...
Preclinical studies rarely test the efficacy of therapies in both sexes. The field oncology is no exception this regard. In a model syngeneic, orthotopic, metastasized pancreatic ductal adenocarcinoma we evaluated impact sex on pathological features disease as well and possible adverse side effects novel, small molecule-based therapy inhibiting KRAS:SOS1, MEK1/2 PI3K signaling male female C57BL/6J mice. Male mice had less tumor infiltration CD8-positive cells, developed bigger tumors, more...
We use spectroscopic ellipsometry to obtain the complex refractive index, $\~n=n+ik,$ of human fingernails. By studying change $\~n$ upon hydration and dehydration, we reveal three different time domains with typical constants 4, 150, 3200 min. A simple model that takes into account presence one fast slow process is fully consistent observed dehydration dynamics. attribute these processes ``free'' water incorporated between keratin filaments more tightly ``bound'' in complexes, respectively....
We study the behavior of optical properties human skin across its layers. describe ellipsometric measurements for spectrally resolved in vivo investigations biological tissue. show on parameters and , which change polarization light reflection a sample. A tape-stripping reveals depth profile into stratum corneum. The shows an increase both quantities with increased depth. Analyzing development number strips using exponential function steady state after approximately 2 µm. evolution can be...