Thomas Lehner
A5089007009- Oral microbiology and periodontitis research
- HIV Research and Treatment
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Streptococcal Infections and Treatments
- Immune Response and Inflammation
- Ocular Diseases and Behçet’s Syndrome
- Salivary Gland Disorders and Functions
- Genetic Associations and Epidemiology
- Oral Health Pathology and Treatment
- Glycosylation and Glycoproteins Research
- Monoclonal and Polyclonal Antibodies Research
- Genomics and Rare Diseases
- Herpesvirus Infections and Treatments
- Immunodeficiency and Autoimmune Disorders
- Hepatitis B Virus Studies
- Otitis Media and Relapsing Polychondritis
- Systemic Lupus Erythematosus Research
- Genetics and Neurodevelopmental Disorders
- Oral and gingival health research
- Heat shock proteins research
- Autism Spectrum Disorder Research
- HIV/AIDS oral health manifestations
- Infective Endocarditis Diagnosis and Management
New York Genome Center
2020-2024
National Institute of Mental Health
2012-2023
New York Psychoanalytic Society and Institute
1990-2021
New York State Psychiatric Institute
1989-2021
University of Bamberg
2021
National Institutes of Health
2009-2020
Guy's Hospital
2007-2019
University of Salzburg
2019
King's College London
2009-2019
Medical University of Graz
2019
Four transgenic Nicotiana tabacum plants were generated that expressed a murine monoclonal antibody kappa chain, hybrid immunoglobulin A-G heavy joining and rabbit secretory component, respectively. Successive sexual crosses between these filial recombinants resulted in all four protein chains simultaneously. These assembled into functional, high molecular weight recognized the native streptococcal antigen I/II cell surface adhesion molecule. In plants, single cells are able to assemble...
Abstract The availability of high-quality RNA-sequencing and genotyping data post-mortem brain collections from consortia such as CommonMind Consortium (CMC) the Accelerating Medicines Partnership for Alzheimer’s Disease (AMP-AD) enable generation a large-scale cis- eQTL meta-analysis. Here we generate cerebral cortical 1433 samples available four cohorts (identifying >4.1 million significant >18,000 genes), well cerebellar 261 874,836 >10,000 genes). We find substantially improved...
Abstract The peptide binding C-terminal portion of heat shock protein (HSP)70 (aa 359–610) stimulates human monocytes to produce IL-12, TNF-α, NO, and C-C chemokines. N-terminal, ATPase (HSP701–358) failed stimulate any these cytokines or Both native the truncated HSP70359–610 stimulation chemokine production is mediated by CD40 costimulatory molecule. Maturation dendritic cells was induced with HSP70, not seen N-terminal HSP701–358, but enhanced HSP70359–610, as demonstrated up-regulation...
A surface protein antigen of Streptococcus mutans having two sets antigenic determinants (antigens I and II) was purified by column chromatography from culture supernatants S. serotype c. The protease-resistant component, II, pronase-digested I/II. antigens were analyzed chemically immunologically, their physicochemical properties investigated. Antigen I/II consisted more than 80% protein, its peptide chain molecular weight estimated to be 185,000. II approximately 60% with a 48,000....
The etiology of Behcet's syndrome (BS) is unknown, but a number streptococcal species have been implicated. A hypothesis was postulated that shared antigen, such as stress protein, might account for some these findings. Indeed, rabbit antiserum against 65-kDa heat shock protein Mycobacterium tuberculosis revealed corresponding band with all six Streptococcus sanguis strains examined and S. pyogenes not salivarius. By applying panel nine monoclonal antibodies to the mycobacterial an...
Abstract The genes encoding the heavy and light chains of a murine monoclonal antibody (mAb Guy's 13) have been cloned expressed in Nicotiana tabacum. Transgenic plants regenerated that secrete full‐length 13 antibody. By manipulation chain gene sequence, constant region domains from an immunoglobulin alpha introduced, secreting mAb with chimeric gamma/alpha also produced. For each plant antibody, detected by Western blot analysis fidelity assembly confirmed demonstrating is fully...