Meiyan Wang
A5060900670- Genomic variations and chromosomal abnormalities
- Genomics and Rare Diseases
- Pluripotent Stem Cells Research
- CRISPR and Genetic Engineering
- Cancer Genomics and Diagnostics
- Single-cell and spatial transcriptomics
- Neuroscience and Neuropharmacology Research
- Neurogenesis and neuroplasticity mechanisms
- Genomics and Phylogenetic Studies
- Retinal Development and Disorders
- Renal and related cancers
- RNA Interference and Gene Delivery
- Genetics, Aging, and Longevity in Model Organisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Genetic Associations and Epidemiology
- Hedgehog Signaling Pathway Studies
- Fetal and Pediatric Neurological Disorders
- Cell Image Analysis Techniques
- Spectroscopy and Chemometric Analyses
- Tissue Engineering and Regenerative Medicine
- Epigenetics and DNA Methylation
- Genomics and Chromatin Dynamics
- Machine Learning in Materials Science
- Tryptophan and brain disorders
- Virus-based gene therapy research
Rutgers, The State University of New Jersey
2024
Salk Institute for Biological Studies
2017-2024
Mayo Clinic
2022
University of California, San Diego
2012-2020
Shenzhen Children's Hospital
2014
We analyzed 131 human brains (44 neurotypical, 19 with Tourette syndrome, 9 schizophrenia, and 59 autism) for somatic mutations after whole genome sequencing to a depth of more than 200×. Typically, had 20 60 detectable single-nucleotide mutations, but ~6% harbored hundreds mutations. Hypermutability was associated age damaging in genes implicated cancers and, some brains, reflected vivo clonal expansions. Somatic duplications, likely arising during development, were found ~5% normal...
Abstract Schizophrenia affects approximately 1% of the world population. Genetics, epigenetics, and environmental factors are known to play a role in this psychiatric disorder. While there is high concordance monozygotic twins, about half twin pairs discordant for schizophrenia. To address question how when twins occur, we have obtained fibroblasts from two schizophrenia (one sibling with while second one unaffected by schizophrenia) three healthy (both siblings healthy). We prepared iPSC...
As the renewable source of all cell types in body, human embryonic stem cells (hESCs) hold great promise for therapy. However, one major bottleneck that hinders clinic application hESCs is remaining with their differentiated derivatives pose cancer risk by forming teratomas after transplantation. NANOG a critical pluripotency factor specifically expressed but rarely derivatives. By introducing hyperactive variant herpes simplex virus thymidine kinase gene into 3′-untranslated region...
Abstract When somatic cells acquire complex karyotypes, they often are removed by the immune system. Mutant that evade surveillance can lead to cancer. Neurons with karyotypes arise during neurotypical brain development, but neurons almost never origin of cancers. Instead, mutations in bring about neurodevelopmental disorders, and contribute polygenic landscape neuropsychiatric neurodegenerative disease. A subset human harbors idiosyncratic copy number variants (CNVs, “CNV neurons”),...
Human embryonic stem cells (hESCs) depend on glycolysis for energy supply and pluripotency switch to oxidative phosphorylation upon differentiation. The underlying mechanisms remain unclear. Here, we demonstrate that indoleamine 2,3-dioxygenase 1 (IDO1) is expressed in primed hESCs its expression rapidly downregulated hESC IDO1 required maintain by suppressing mitochondria activity promoting through the increase of NAD+ /NADH ratio. upregulation during differentiation suppresses into certain...
The phase transition of cadmium selenide (CdSe) from wurtzite to rocksalt structure has been the subject extensive research. In this study, we present a novel approach combining machine learning potentials with swarm intelligence-based pathway sampling elucidate complex mechanisms in CdSe. We developed an accurate machine-learning (ML) potential for CdSe, validated against density functional theory calculations, achieving mean absolute errors (MAEs) 1.8 meV/atom energies and 33 meV/Å forces....
Abstract Somatic mosaicism is defined as an occurrence of two or more populations cells having genomic sequences differing at given loci in individual who derived from a single zygote. It characteristic multicellular organisms that plays crucial role normal development and disease. To study the nature extent somatic autism spectrum disorder, bipolar focal cortical dysplasia, schizophrenia, Tourette syndrome, multi-institutional consortium called Brain Mosaicism Network (BSMN) was formed...
Abstract Red light optogenetic systems are in high demand for the precise control of gene expression gene- and cell-based therapies. Here, we report a red /far-red light-inducible p hotoswitch (REDLIP) system based on chimeric photosensory protein FnBphP (Fn-REDLIP) or PnBphP (Pn-REDLIP) their interaction partner LDB3, which enables efficient dynamic regulation with timescale seconds without exogenous administration chromophore mammals. We used REDLIP to establish REDLIP-mediated...