Patrick Turley
A5086099853- Genetic Associations and Epidemiology
- Genetic Mapping and Diversity in Plants and Animals
- Genetic and phenotypic traits in livestock
- Intergenerational and Educational Inequality Studies
- Birth, Development, and Health
- Cognitive Abilities and Testing
- Genetics and Neurodevelopmental Disorders
- Global Health Care Issues
- Autism Spectrum Disorder Research
- Nutrition, Genetics, and Disease
- Attention Deficit Hyperactivity Disorder
- Bioinformatics and Genomic Networks
- Assisted Reproductive Technology and Twin Pregnancy
- Dental Implant Techniques and Outcomes
- Reproductive Health and Technologies
- Orthodontics and Dentofacial Orthopedics
- Dental Education, Practice, Research
- BRCA gene mutations in cancer
- Temporomandibular Joint Disorders
- Genomics and Rare Diseases
- dental development and anomalies
- Obesity, Physical Activity, Diet
- Prenatal Screening and Diagnostics
- demographic modeling and climate adaptation
- Medical and Biological Sciences
University of Southern California
2018-2025
National Bureau of Economic Research
2019-2024
University of California, Los Angeles
1983-2024
New York University
2021-2024
Massachusetts General Hospital
2016-2023
Harvard University
2015-2023
Broad Institute
2016-2023
Southern California University for Professional Studies
2021-2023
Geisinger Health System
2021
Brigham and Women's Hospital
2021
Disorders of the brain can exhibit considerable epidemiological comorbidity and often share symptoms, provoking debate about their etiologic overlap. We quantified genetic sharing 25 disorders from genome-wide association studies 265,218 patients 784,643 control participants assessed relationship to 17 phenotypes 1,191,588 individuals. Psychiatric common variant risk, whereas neurological appear more distinct one another psychiatric disorders. also identified significant between a number...
Genes overlap across psychiatric disease Many genome-wide studies have examined genes associated with a range of neuropsychiatric disorders. However, the degree to which genetic underpinnings these diseases differ or is unknown. Gandal et al. performed meta-analyses transcriptomic covering five major disorders and compared cases controls identify coexpressed gene modules. From this, they found that some share global expression patterns. This in polygenic traits may allow for better diagnosis...
Estimates from genome-wide association studies (GWAS) of unrelated individuals capture effects inherited variation (direct effects), demography (population stratification, assortative mating) and relatives (indirect genetic effects). Family-based GWAS designs can control for demographic indirect effects, but large-scale family datasets have been lacking. We combined data 178,086 siblings 19 cohorts to generate population (between-family) within-sibship (within-family) estimates 25...
Abstract Attention-Deficit/Hyperactivity Disorder (ADHD) is a highly heritable childhood behavioral disorder affecting 5% of school-age children and 2.5% adults. Common genetic variants contribute substantially to ADHD susceptibility, but no individual have been robustly associated with ADHD. We report genome-wide association meta-analysis 20,183 cases 35,191 controls that identifies surpassing significance in 12 independent loci, revealing new important information on the underlying biology...
Companies have recently begun to sell a new service patients considering in vitro fertilization: embryo selection based on polygenic scores (ESPS). These represent individualized predictions of health and other outcomes derived from genomewide association studies adults partially predict these outcomes. This article includes discussion many factors that lower the predictive power context quantifies effects for variety clinical nonclinical traits. Also discussed are potential unintended...
Effects estimated by genome-wide association studies (GWASs) include effects of alleles in an individual on that (direct genetic effects), indirect (for example, parents offspring through the environment) and bias from confounding. Within-family variation is random, enabling unbiased estimation direct when are genotyped. However, parental genotypes often missing. We introduce a method imputes missing estimates effects. Our method, implemented software package snipar (single-nucleotide...
Summary Large biobanks, such as the UK Biobank (UKB), enable massive phenome by genome-wide association studies that elucidate genetic etiology of complex traits. However, individuals from diverse ancestry groups are often excluded analyses due to concerns about population structure introducing false positive associations. Here, we generate mixed model associations and meta-analyses across groups, inclusive a larger fraction UKB than previous efforts, produce freely-available summary...
Abstract We develop a method, SBayesRC, that integrates genome-wide association study (GWAS) summary statistics with functional genomic annotations to improve polygenic prediction of complex traits. Our method is scalable whole-genome variant analysis and refines signals from by allowing them affect both causal probability effect distribution. analyze 50 traits diseases using ∼7 million common single-nucleotide polymorphisms (SNPs) 96 annotations. SBayesRC improves accuracy 14% in European...
Gestational diabetes mellitus (GDM) is a common metabolic disorder affecting more than 16 million pregnancies annually worldwide
This work investigates whether genetic makeup moderates the effects of education on health. Low statistical power and endogenous measures environment have been obstacles to credible estimation such gene-by-environment interactions. We overcome these by combining a natural experiment that generated variation in secondary with polygenic scores for quarter-million individuals. The additional schooling affected body size, lung function, blood pressure middle age. improvements size function were...
Abstract We conducted genome-wide association studies (GWAS) of relative intake from the macronutrients fat, protein, carbohydrates, and sugar in over 235,000 individuals European ancestries. identified 21 unique, approximately independent lead SNPs. Fourteen SNPs are uniquely associated with one macronutrient at significance ( P < 5 × 10 −8 ), while five reach suggestive 1 −5 ) for least other macronutrient. While phenotypes genetically correlated, each phenotype carries a partially...
Abstract Autism spectrum disorder (ASD) is a highly heritable and heterogeneous group of neurodevelopmental phenotypes diagnosed in more than 1% children. Common genetic variants contribute substantially to ASD susceptibility, but date no individual have been robustly associated with ASD. With marked sample size increase from unique Danish population resource, we report genome-wide association meta-analysis 18,381 cases 27,969 controls that identifies five significant loci. Leveraging GWAS...
Abstract Humans vary substantially in their willingness to take risks. In a combined sample of over one million individuals, we conducted genome-wide association studies (GWAS) general risk tolerance, adventurousness, and risky behaviors the driving, drinking, smoking, sexual domains. We identified 611 approximately independent genetic loci associated with at least our phenotypes, including 124 tolerance. report evidence substantial shared influences across tolerance behaviors: 72 contain...
Abstract Estimates from genome-wide association studies (GWAS) represent a combination of the effect inherited genetic variation (direct effects), demography (population stratification, assortative mating) and nurture relatives (indirect effects). GWAS using family-based designs can control for indirect effects, but large-scale family datasets have been lacking. We combined data on 159,701 siblings 17 cohorts to generate population (between-family) within-sibship (within-family) estimates...
Abstract In this consensus report by a diverse group of academics who conduct and/or are concerned about social and behavioral genomics (SBG) research, the authors recount often‐ugly history scientific attempts to understand genetic contributions human behaviors outcomes. They then describe what current science—including genomewide association studies polygenic indexes—can cannot tell us, as well its risks potential benefits. conclude with discussion responsible behavior in context SBG...
Understanding moral acceptability and willingness to use is crucial for informing policy
Abstract Cognitive functions of individuals with psychiatric disorders differ from that the general population. Such cognitive differences often manifest early in life as differential school performance and have a strong genetic basis. Here we measured predictors 30,982 English, Danish mathematics via genome-wide association study (GWAS) studied their relationship risk for six major disorders. When decomposing into math language-specific performances, observed phenotypically genetically...
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