A5100458714- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Urological Disorders and Treatments
- Problem and Project Based Learning
- Radiomics and Machine Learning in Medical Imaging
- Genetic Associations and Epidemiology
- Interprofessional Education and Collaboration
- Ethics in Clinical Research
- Biomedical Ethics and Regulation
- Bladder and Urothelial Cancer Treatments
- Assisted Reproductive Technology and Twin Pregnancy
- RNA Interference and Gene Delivery
- CRISPR and Genetic Engineering
- Urologic and reproductive health conditions
- Ureteral procedures and complications
- Hormonal and reproductive studies
- Sperm and Testicular Function
- Genetic Syndromes and Imprinting
- Ear and Head Tumors
- Facial Trauma and Fracture Management
- Higher Education Practises and Engagement
- Pharmacological Effects and Assays
- Sexual function and dysfunction studies
- Electroconvulsive Therapy Studies
- Aortic Disease and Treatment Approaches
Baylor College of Medicine
2025
Fraser Health
2025
Stanford University
2003-2021
Massachusetts General Hospital
2016-2021
The University of Queensland
2021
National Bureau of Economic Research
2021
University of California, Los Angeles
2021
Geisinger Health System
2021
University of Southern California
2021
Harvard University
2021
BackgroundMultiparametric magnetic resonance imaging (mpMRI) interpreted by experts is a powerful tool for diagnosing prostate cancer. However, the generalizability of published results across radiologists varying expertise has not been verified.ObjectiveTo assess variability in mpMRI reporting and diagnostic accuracy experience routine clinical care.Design, setting, participantsMen who underwent MR-fusion biopsy between 2014–2016. Each MRI scan was read one nine using Prostate Imaging...
Companies have recently begun to sell a new service patients considering in vitro fertilization: embryo selection based on polygenic scores (ESPS). These represent individualized predictions of health and other outcomes derived from genomewide association studies adults partially predict these outcomes. This article includes discussion many factors that lower the predictive power context quantifies effects for variety clinical nonclinical traits. Also discussed are potential unintended...
RNA interference (RNAi) is an evolutionarily conserved mechanism in plant and animal cells that directs the degradation of messenger RNAs homologous to short double-stranded termed small interfering (siRNA). The ability siRNA direct gene silencing mammalian has raised possibility might be used investigate function a high throughput fashion or modulate expression human diseases. specificity siRNA-mediated silencing, critical consideration these applications, not been addressed on genomewide...
Intravascular transplantation of neural stem cells represents a minimally invasive therapeutic approach for the treatment central nervous system diseases. The cellular biodistribution after intravascular injection needs to be analyzed determine ideal delivery modality. We studied and efficiency targeted comparing intravenous intra-arterial (IA) administration brain ischemia.Mouse were transduced with firefly luciferase reporter gene bioluminescence imaging (BLI). Hypoxic-ischemia was induced...
Background: Many people experiment with alcohol and other drugs of abuse during their teenage years. Epidemiological evidence suggests that younger initiates into drug taking are more likely to develop problematic seeking behavior, including binge high‐intake behaviors. The level intake for any individual depends on the balance rewarding aversive effects in individual. Multiple rodent studies have demonstrated reduced adolescent compared adult animals. In this study, we addressed 2 key...
Abstract This report reviews 5 cases of mitral annular caseoma. Four patients presented with fatigue, stroke, or stenosis. Robot-assisted resection caseoma without valve replacement was successfully performed in all good outcomes. These demonstrate the safety and efficacy robotic surgery treating
Summary Studies have suggested an association between varicocele, hypogonadism, and elevated oxidative stress markers, but no other health risks been associated with varicoceles. We sought to determine the varicocele incident medical comorbidities. Using Truven Health MarketScan ® claims database from 2001 2009, we identified 4459 men varicoceles, 100,066 controls based on ICD‐9 CPT codes, average follow‐up of 3.1 person years. Men...
Djenkolism is an uncommon but important cause of acute kidney injury. It sporadically occurs after ingestion the djenkol bean (Archidendron pauciflorum), which native to Southeast Asia. The clinical features defining djenkolism include: spasmodic suprapubic and/or flank pain; urinary obstruction; and precise pathogenesis injury following remains unknown. However, it proposed that interaction between characteristics ingested beans host factors causes hypersaturation djenkolic acid crystals...
(Abstracted from N Engl J Med 2021;385:78–86) Embryo selection based on polygenic scores (ESPS) is the principle wherein one can select individualized embryos to transfer as part of in vitro fertilization predictions health and other outcomes derived genome-wide association studies (GWASs). The majority human traits including physical characteristics risk for disease are influenced by cumulative differences genetic variants.
To create an online resource that teaches urologists how to interpret prostate multiparametric magnetic resonance imaging (mpMRI). As mpMRI becomes widely adopted for cancer diagnosis and targeted biopsy, it is increasingly important are comfortable experienced in assessing the images. The purpose of this study was ibook measure its effect on instilling proficiency among urology residents.We created a case-based aimed at teaching clinicians identify score lesions using Prostate...
That sweat gland type tumors occur occasionally in the breast is not surprising, as and cutaneous glands are embryologically related. Cylindromas present most commonly solitary sporadic dermal nodules on face scalp. Cases of multiple cylindromas dominantly inherited, neoplasms referred to "turban tumors" when lesions cover Primary cylindroma has been reported once past. To best our knowledge, fine needle aspiration cytology primary its occurrence setting familial cylindromatosis have...
Abstract: Utilization of pre-biopsy multiparametric MRI (mpMRI) is increasing. To optimize the usefulness mpMRI, physicians should accurately quote patients a numerical risk cancer based on their MRI. The Prostate Imaging Reporting and Data System (PIRADS) standardizes interpretation mpMRI; however, reported rates clinically significant prostate (CSC) stratified by PIRADS score vary widely. While some publications use radical prostatectomy (RP) specimens as gold standard, others biopsy. We...
The authors present a case of fat embolism syndrome after traumatic long-bone fracture in patient with rapid neurologic deterioration and multiple cerebral embolic events. Diagnostic workup revealed the neuroradiologic findings classically described emboli. hallmark ultrasound imaging echogenic material actively traveling through inferior vena cava.
The PRECISION trial provides level 1 evidence supporting prebiopsy multiparametric magnetic resonance imaging (mpMRI) followed by targeted biopsy only when mpMRI is abnormal [1]. This approach reduced over-detection of low-grade cancer while increasing detection clinically significant (CSC). Still, important questions remain regarding the reproducibility these findings outside a clinical and quantifying missed CSC diagnoses using this approach. To address issues, we retrospectively applied...
OPEN ACCESSJanuary 19, 2014Team Based Learning: Preterm Labor (PTL), Premature Rupture of Membranes (PPROM) and Medical Complications Pregnancy Alice Chuang, MD, Nancy Wang MD University North Carolina at Chapel Hill School Medicine , https://doi.org/10.15766/mep_2374-8265.9668 SectionsAbout ToolsDownload Citations ShareFacebookTwitterEmail AbstractThis team-based learning module instructs obstetrics gynecology clerkship students on the diagnosis initial management pregnancy complications....
OPEN ACCESSFebruary 13, 2014Team Based Learning: Fibroids, Normal and Abnormal Uterine Bleeding, Amenorrhea Infertility Alice Chuang, MD, Nancy Wang, Aileen Beckham MD University of North Carolina at Chapel Hill School Medicine , Wang https://doi.org/10.15766/mep_2374-8265.9715 SectionsAbout ToolsDownload Citations ShareFacebookTwitterEmail Abstract Introduction: This team-based learning (TBL) module instructs obstetrics gynecology clerkship students on diagnosis initial management...
Fetal ultrasound examination at 29 weeks' gestation revealed a severely symmetrically growth-retarded fetus with microcephaly, hypertelorism, and hypoplastic genitalia two-vessel umbilical cord. G-banding analysis on amniotic cell cultures 46,XY,r (4) (p15-q35) karyotype in each of the colonies analyzed. This prenatal diagnosis, to our knowledge first reported, assisted clinical management this pregnancy.
Objective: Safe and effective antipsychotic prescribing is a fundamental skill in psychiatric practice; however, medications are not without risk. These risks increased when antipsychotics prescribed high doses, with or polypharmacy. Decision-making regarding can be hampered by lack of readily available easily approachable tools for calculating interpreting total daily especially polypharmacy involved. Our objective was to create an accessible method dosing. Methods: We have developed online...
The Partners Neurology Residency Program spans two neurology departments in Boston. of the Brigham and Women's Massachusetts General Hospitals comprise 325 faculty members 53 residents. Given this large community vast number opportunities that are available at these academic institutions, it is critical to have a system disseminate information inform important events. In era digital technology, email web-based media provide an opportunity for efficient communication. One way which...