Tetyana Zayats
A5088265023- Attention Deficit Hyperactivity Disorder
- Genetics and Neurodevelopmental Disorders
- Autism Spectrum Disorder Research
- Genetic Associations and Epidemiology
- Corneal surgery and disorders
- Epigenetics and DNA Methylation
- Ophthalmology and Visual Impairment Studies
- Functional Brain Connectivity Studies
- Child and Adolescent Psychosocial and Emotional Development
- Health, Environment, Cognitive Aging
- Genomic variations and chromosomal abnormalities
- Bipolar Disorder and Treatment
- Cognitive Abilities and Testing
- Glaucoma and retinal disorders
- Cardiovascular Health and Risk Factors
- Health and Lifestyle Studies
- Parkinson's Disease Mechanisms and Treatments
- Health and Well-being Studies
- Retinal Diseases and Treatments
- Atherosclerosis and Cardiovascular Diseases
- Congenital heart defects research
- Birth, Development, and Health
- Animal Nutrition and Physiology
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Hip disorders and treatments
Broad Institute
2019-2024
University of Oslo
2021-2024
Massachusetts General Hospital
2018-2024
Haukeland University Hospital
2014-2024
University of Bergen
2014-2023
Harvard University
2018-2023
Stanley Foundation
2019-2020
Genomics (United Kingdom)
2019
Yale University
2013-2014
University of Bristol
2010-2011
Attention-deficit/hyperactivity disorder (ADHD) is a highly heritable common childhood-onset neurodevelopmental disorder. Some rare copy number variations (CNVs) affect multiple disorders such as intellectual disability, autism spectrum (ASD), schizophrenia and ADHD. The aim of this study to determine what extent ADHD shares high risk CNV alleles with ASD. We compiled 19 neuropsychiatric CNVs test 14, sufficient power, for association in Icelandic Norwegian samples. Eight associate ADHD;...
Abstract Background The Norwegian Mother, Father, and Child Cohort Study (MoBa) is a population-based pregnancy cohort, which includes approximately 114,500 children, 95,200 mothers, 75,200 fathers. Genotyping of MoBa has been conducted through multiple research projects, spanning several years; using varying selection criteria, genotyping arrays, centres. contains numerous interrelated families, necessitated the implementation family-based quality control (QC) pipeline that verifies...
The ratio of the lengths an individual's second to fourth digit (2D:4D) is commonly used as a noninvasive retrospective biomarker for prenatal androgen exposure. In order identify genetic determinants 2D:4D, we applied genome-wide association approach 1507 11-year-old children from Avon Longitudinal Study Parents and Children (ALSPAC) in whom 2D:4D had been measured, well sample 1382 12- 16-year-olds Brisbane Adolescent Twin Study. A meta-analysis two scans identified single variant LIN28B...
Abstract Attention deficit hyperactivity disorder (ADHD) is a prevalent childhood psychiatric disorder, with major genetic component. Here we present GWAS meta-analysis of ADHD comprising 38,691 individuals and 186,843 controls. We identified 27 genome-wide significant loci, which more than twice the number previously reported. Fine-mapping risk loci highlighted 76 potential genes enriched in expressed brain, particularly frontal cortex, early brain development. Overall, was associated...
Attention-deficit/hyperactivity disorder (ADHD) and autism spectrum (ASD) share common genetic factors but seem to have specific patterns of psychiatric comorbidities. There are few systematic studies on adults; therefore, we compared comorbidities in adults with these two neurodevelopmental disorders using population-based data analyzed their correlations evaluate underlying factors.Using from Norwegian registries, assessed ADHD (n = 38,636; 2.3%), ASD 7528; 0.4%), both diagnoses 1467;...
Collagen involvement in myopia development via scleral remodeling is well-known. Recently, COL1A1 and COL2A1 gene polymorphisms were reported to be associated with high-grade common myopia, respectively. This study was conducted investigate whether these collagen genes are and/or genetically linked large Caucasian family datasets.High-grade defined as <or=-5.00 D. Two independent datasets comprising 146 (Duke) 130 (Cardiff) families participated the association study. Allelic discrimination...
Aggressiveness is a behavioral trait that has the potential to be harmful individuals and society. With an estimated heritability of about 40%, genetics important in its development. We performed exploratory genome-wide association (GWA) analysis childhood aggressiveness attention deficit hyperactivity disorder (ADHD) gain insight into underlying biological processes associated with this trait. Our primary sample consisted 1,060 adult ADHD patients (aADHD). To further explore genetic...
Abstract Attention-Deficit/Hyperactivity Disorder (ADHD) is a common neurodevelopmental disorder with only symptomatic care available. Genome-wide association (GWA) studies can provide starting point in the search for novel drug targets and possibilities of repurposing. Here, we explored druggable genome ADHD by utilising GWA on its co-morbid conditions. First, whether genes targeted current drugs show and/or co-morbidities. Second, aimed to identify pathways involved biological processes...
Mesenteric venous thrombosis is a rare pathology. The outcomes of the mesenteric treatment remain disappointing and directly depend on preoperative disease duration. This article presents description case complicated by sepsis with fatal outcome. presence generalized infection was established 25th day hospital stay, one before patient’s death. not diagnosed during patient's lifetime. clinical confirms fact that due to paucisymptomatic course, absence pathognomonic symptoms, rarity pathology,...
Abstract Attention-deficit/hyperactivity disorder (ADHD) is a highly heritable childhood-onset neuropsychiatric condition, often persisting into adulthood. The genetic architecture of ADHD, particularly in adults, largely unknown. We performed an exome-wide scan adult ADHD using the Illumina Human Exome Bead Chip, which interrogates over 250 000 common and rare variants. Participants were recruited by International Multicenter persistent CollaboraTion (IMpACT). Statistical analyses divided 3...