A5021656534- Tryptophan and brain disorders
- Autism Spectrum Disorder Research
- Stress Responses and Cortisol
- Genetics and Neurodevelopmental Disorders
- Bipolar Disorder and Treatment
- Adolescent and Pediatric Healthcare
- Family and Disability Support Research
- Genetic Associations and Epidemiology
- Inflammasome and immune disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Schizophrenia research and treatment
- Metabolism and Genetic Disorders
- Attention Deficit Hyperactivity Disorder
- Neuroendocrine regulation and behavior
- Folate and B Vitamins Research
- Genomic variations and chromosomal abnormalities
- Diabetes and associated disorders
- Infant Health and Development
- Vitamin D Research Studies
- Muscle metabolism and nutrition
- Nerve injury and regeneration
- Genetic Syndromes and Imprinting
- Birth, Development, and Health
- Child Abuse and Trauma
- Electrolyte and hormonal disorders
Oslo University Hospital
2015-2024
University of Oslo
2015-2024
University of Siena
2021
University College London
2018
Diakonhjemmet Hospital
2010-2012
Østfold Hospital Trust
2009-2012
Children's Hospital at Westmead
1995
Background: Alterations in the inflammatory system have been associated with schizophrenia and major depression, while bipolar disorder has less studied. Most previous studies examined small samples, literature is inconsistent regard to specific underlying immune mechanisms. In present study, we markers representing different pathways, aim was investigate whether levels of parameters a representative sample are elevated compared healthy controls, profile between groups. Methods: Plasma...
Previous studies suggest elevated inflammation in schizophrenia and bipolar disorder, with increased activity of the Interleukin 1 (IL-1), interleukin 6 (IL-6), tumor necrosis factor (TNF)-alpha, von Willebrand (vWf) osteoprotegerin (OPG). It is unclear how immune activation involved psychopathology. We investigated if was associated disease severity (trait) or current symptom level (state), comparing psychotic general characteristics.Plasma levels sTNF receptor (sTNF-R1), IL-1 antagonist...
The Wnt signaling pathway plays a crucial role in neurodevelopment and regulating the function structure of adult nervous system. Schizophrenia (SCZ) bipolar disorder (BD) are severe mental disorders with evidence subtle neurodevelopmental, structural functional neuronal abnormalities. We aimed to elucidate aberrant regulation system these by evaluating plasma levels secreted modulators patients (SCZ = 551 BD 246) healthy controls (HCs 639) using enzyme immune-assay. also investigated...
Abstract Autism spectrum disorder (ASD) is a highly heritable and heterogeneous group of neurodevelopmental phenotypes diagnosed in more than 1% children. Common genetic variants contribute substantially to ASD susceptibility, but date no individual have been robustly associated with ASD. With marked sample size increase from unique Danish population resource, we report genome-wide association meta-analysis 18,381 cases 27,969 controls that identifies five significant loci. Leveraging GWAS...
The neuropeptide oxytocin has shown promise as a treatment for symptoms of autism spectrum disorders (ASD). However, clinical research progress been hampered by poor understanding oxytocin's dose-response and sub-optimal intranasal delivery methods. We examined two doses delivered using novel Breath Powered device designed to improve direct nose-to-brain activity in double-blind, crossover, randomized, placebo-controlled trial. In randomized sequence single-dose sessions, 17 male adults with...
A proinflammatory imbalance in the tumor necrosis factor (TNF) system may contribute to pathogenesis of schizophrenia (SCZ) and bipolar disorders (BDs) related comorbidities. We investigated relative distribution TNF-related molecules blood dorsolateral prefrontal cortex (DLPFC) these disorders. measured plasma levels TNF, soluble TNF receptor 1 (sTNFR1), 2 (sTNFR2), a disintegrin metalloprotease-17 (ADAM17) using enzyme immunoassays calculated TNF/sTNFRs ratio (TNF/sTNFR1+sTNFR2) sample 816...
Schizophrenia (SCZ) and bipolar disorder (BD) are severe mental illnesses (SMI) that part of a psychosis continuum, dysregulated innate immune responses have been suggested to be involved in their pathophysiology. However, disease-specific mechanisms SMI not known yet. Recently, dyslipidemia has linked systemic inflammasome activation, elevated atherogenic lipid ratios shown correlate with circulating levels inflammatory biomarkers SMI. It is, however, yet if increased cholesterol load leads...
Inflammation and immune activation have been implicated in the pathogenesis of severe mental disorders cardiovascular disease (CVD). Despite high level comorbidity, many studies system not systematically taken cardiometabolic risk factors into account.We investigated if inflammatory markers were increased schizophrenia (SCZ) affective (AFF) independently comorbid CVD factors. Cardiometabolic (blood lipids, body mass index glucose) CVD-related CXCL16, soluble interleukin-2 receptor (sIL-2R),...
Article Abstract Objective: The hypothalamic-pituitary-adrenal (HPA) axis seems dysregulated and part of the pathophysiology in bipolar disorder schizophrenia, but underlying mechanisms are unknown. Recent evidence indicates that systemic cortisol metabolism influences blood levels HPA functioning. Our objective was to estimate by means activity 5α-reductase, 5β-reductase, 11β-hydroxysteroid dehydrogenase (11β-HSD) patients with schizophrenia spectrum disorders compared healthy controls....
We investigated whether elevated plasma levels of immune markers were associated with verbal memory and hippocampal subfield volumes in patients severe mental illnesses healthy controls.In total, 230 a broad DSM-IV schizophrenia spectrum illness or bipolar disorder 236 controls recruited. Memory was assessed using the Wechsler Scale-Third Edition (WMS-III) Logical immediate delayed recall, California Verbal Learning Test summed recall over learning list (CVLT learning) free recall. measured...
Clinical genetic testing (CGT) of children with autism spectrum disorder (ASD) may have positive and negative effects. Knowledge about parents’ attitudes is needed to ensure good involvement caregivers, which crucial for accurate diagnosis effective clinical management. This study aimed assess toward CGT ASD. Parent members the Norwegian Autism Society were given a previously untested questionnaire 1455 answered. Linear regression analyses conducted evaluate contribution parent child...
Abstract The Notch signaling pathway plays a crucial role in neurodevelopment and adult brain homeostasis. We aimed to further investigate activity bipolar disorder (BD) schizophrenia (SCZ) by conducting analysis. measured plasma levels of ligands (DLL1 DLK1) using enzyme immunoassays large sample patients (SCZ n = 551, BD 246) healthy controls (HC 639). also determined related gene expression microarray analyses from whole blood subsample 338, 241 HC 263). found significantly elevated...
Autism spectrum disorder (ASD) is a highly heritable condition with large variation in cognitive function. Here we investigated the shared genetic architecture between traits (intelligence (INT) and educational attainment (EDU)), risk loci jointly associated ASD traits. We analyzed data from genome-wide association studies (GWAS) of INT (n = 269,867), EDU 766,345) (cases n 18,381, controls 27,969). used bivariate causal mixture model (MiXeR) to estimate total number variants, local analysis...
Objective Immunopathogenic mechanisms have been implicated in schizophrenia and bipolar disorder, genome-wide association studies (GWAS) point to the major histocompatibility complex, a region that contains many immune-related genes. One of strongest candidate risk genes for disorder is NOTCH4 gene within complex. The authors investigated expression individuals with relative healthy comparison subjects identified putative quantitative trait loci around gene. Method measured compared mRNA...