Marija Kundaković
A5089796357- Epigenetics and DNA Methylation
- Genetics and Neurodevelopmental Disorders
- Birth, Development, and Health
- Stress Responses and Cortisol
- Genomics and Chromatin Dynamics
- Single-cell and spatial transcriptomics
- Neuroendocrine regulation and behavior
- Early Childhood Education and Development
- Estrogen and related hormone effects
- Genetic Associations and Epidemiology
- Adipose Tissue and Metabolism
- Neuroscience and Neuropharmacology Research
- RNA Research and Splicing
- Maternal Mental Health During Pregnancy and Postpartum
- Neurogenesis and neuroplasticity mechanisms
- Child and Adolescent Psychosocial and Emotional Development
- Histone Deacetylase Inhibitors Research
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Sex and Gender in Healthcare
- Bioinformatics and Genomic Networks
- Effects and risks of endocrine disrupting chemicals
- RNA modifications and cancer
- Tryptophan and brain disorders
- Neurotransmitter Receptor Influence on Behavior
- Reproductive System and Pregnancy
Fordham University
2016-2025
Icahn School of Medicine at Mount Sinai
2015-2022
Allen Institute for Brain Science
2015-2022
Columbia University
2011-2015
Associated Press
2015
New York Proton Center
2015
Klinika za psihijatriju Vrapče
2013
New York Psychoanalytic Society and Institute
2012
University of Illinois Chicago
2005-2011
Centre for Genomic Regulation
2009
Most genetic risk for psychiatric disease lies in regulatory regions, implicating pathogenic dysregulation of gene expression and splicing. However, comprehensive assessments transcriptomic organization diseased brains are limited. In this work, we integrated genotypes RNA sequencing brain samples from 1695 individuals with autism spectrum disorder (ASD), schizophrenia, bipolar disorder, as well controls. More than 25% the transcriptome exhibits differential splicing or expression,...
Despite progress in defining genetic risk for psychiatric disorders, their molecular mechanisms remain elusive. Addressing this, the PsychENCODE Consortium has generated a comprehensive online resource adult brain across 1866 individuals. The contains ~79,000 brain-active enhancers, sets of Hi-C linkages, and topologically associating domains; single-cell expression profiles many cell types; quantitative-trait loci (QTLs); further QTLs associated with chromatin, splicing, cell-type...
Bisphenol A (BPA) is an estrogenic endocrine disruptor widely used in the production of plastics. Increasing evidence indicates that utero BPA exposure affects sexual differentiation and behavior; however, mechanisms underlying these effects are unknown. We hypothesized may disrupt epigenetic programming gene expression brain. Here, we provide maternal during pregnancy to environmentally relevant doses (2, 20, 200 µg/kg/d) mice induces sex-specific, dose-dependent (linear curvilinear), brain...
Early-life adversity increases the risk for psychopathology in later life. The underlying mechanism(s) is unknown, but epigenetic variation represents a plausible candidate. exposures can disrupt programming brain, with lasting consequences gene expression and behavior. This evidence primarily derived from animal studies, limited study humans due to inaccessibility of target brain tissue. In humans, although there DNA methylation changes peripheral blood psychiatric patients, fundamental...
Prenatal maternal psychological distress increases risk for adverse infant outcomes. However, the biological mechanisms underlying this association remain unclear. stress can impact fetal epigenetic regulation that could underlie changes in responses. It has been suggested glucocorticoids may mediate effect. We examined hypothesis by determining of cortisol and depressive symptoms during pregnancy on NR3C1 BDNF DNA methylation. Fifty-seven pregnant women were recruited second or third...
Reelin and glutamic acid decarboxylase 67 (GAD67) mRNAs protein levels are substantially reduced in postmortem brains of patients with schizophrenia. Increasing evidence suggests that the observed down-regulation reelin GAD67 gene expression may be caused by dysfunction epigenetic regulatory mechanisms operative cortical GABAergic interneurons. To explore whether human coordinately regulated through DNA methylation-dependent mechanisms, we studied effects methyltransferase inhibitors on NT-2...
Early life adversity can have a significant long-term impact with implications for the emergence of psychopathology. Disruption to mother-infant interactions is form early that may, in particular, profound programming effects on developing brain. However, despite converging evidence from human and animal studies, precise mechanistic pathways underlying adversity-associated neurobehavioral changes has yet be elucidated. One approach study mechanism exploration epigenetic associated...
The epigenetic down-regulation of genes is emerging as a possible underlying mechanism the GABAergic neuron dysfunction in schizophrenia. For example, evidence has been presented to show that promoters associated with reelin and GAD67 are down-regulated consequence DNA methyltransferase (DNMT)-mediated hypermethylation. Using neuronal progenitor cells study this regulation, we have previously demonstrated DNMT inhibitors coordinately increase mRNAs. Here, report another group drugs, histone...
Abstract Male and female brains differ significantly in both health disease, yet the brain has been understudied. Sex-hormone fluctuations make particularly dynamic are likely to confer female-specific risks for neuropsychiatric disorders. The molecular mechanisms underlying nature of structure function unknown. Here we show that neuronal chromatin organization ventral hippocampus mouse fluctuates with oestrous cycle. We find organizational changes associated transcriptional activity genes...
Cellular heterogeneity in the human brain obscures identification of robust cellular regulatory networks, which is necessary to understand function non-coding elements and impact genetic variation. Here we integrate genome-wide chromosome conformation data from purified neurons glia with transcriptomic enhancer profiles, characterize gene landscape two major cell classes brain. We then leverage cell-type-specific landscapes gain insight into etiology several disorders. find that Alzheimer's...
Stress during sensitive developmental periods can adversely affect physical and psychological development contribute to later-life mental disorders. In particular, adverse experiences childhood dramatically increase the risk for of depression anxiety Although women reproductive age are twice as likely develop than men corresponding age, little is known about sex-specific factors that promote or protect against psychopathology. To examine potential mechanisms driving sex disparity in...
Abstract Background Ovarian hormone fluctuations over the rodent estrous cycle and human menstrual are known to significantly impact brain physiology disease risk, yet this variable is largely ignored in preclinical neuroscience research, clinical studies, psychiatric practice. Methods To assess importance of information for analysis sex differences we re-analyzed our previously published data with or without information, giving a side-by-side comparison analyses behavior, structure, gene...