A5042069600- Cancer, Hypoxia, and Metabolism
- Gut microbiota and health
- Ubiquitin and proteasome pathways
- RNA modifications and cancer
- Cell death mechanisms and regulation
- Mitochondrial Function and Pathology
- Genetics, Aging, and Longevity in Model Organisms
- Acute Myeloid Leukemia Research
- Liver Disease Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Retinoids in leukemia and cellular processes
- Mechanisms of cancer metastasis
- Advanced Proteomics Techniques and Applications
- Traditional and Medicinal Uses of Annonaceae
- Pancreatic and Hepatic Oncology Research
- RNA Interference and Gene Delivery
- Metabolism, Diabetes, and Cancer
- Cancer-related molecular mechanisms research
- Alcohol Consumption and Health Effects
- Diet and metabolism studies
- Dietary Effects on Health
- Virus-based gene therapy research
- Peptidase Inhibition and Analysis
- Gastrointestinal motility and disorders
- Clostridium difficile and Clostridium perfringens research
Minhang District Central Hospital
2015-2024
Fudan University
2015-2024
State Key Laboratory of Respiratory Disease
2023
King's College London
2023
Chinese Academy of Sciences
2006-2023
University of Chinese Academy of Sciences
2023
Dalian Medical University
2023
Second Affiliated Hospital of Dalian Medical University
2023
Shanghai Jiao Tong University
2008-2021
Nanjing University
2021
We report improved whole-genome shotgun sequences for the genomes of indica and japonica rice, both with multimegabase contiguity, or almost 1,000-fold improvement over drafts 2002. Tested against a nonredundant collection 19,079 full-length cDNAs, 97.7% genes are aligned, without fragmentation, to mapped super-scaffolds one other genome. introduce gene identification procedure plants that does not rely on similarity known remove erroneous predictions resulting from transposable elements....
Background: Anti-PD-1-based immunotherapy has emerged as a promising therapy for several cancers. However, it only benefits small subset of colorectal cancer (CRC) patients. Mounting data supports the pivotal role gut microbiota in shaping immune system. Pectin, widely consumed soluble fiber, been reported to ameliorate imbalance microbiota. Therefore, we aimed explore effect and underlying mechanisms pectin improving anti-PD-1 mAb efficacy. Methods: The C57BL/6 mice were treated with...
Abstract Purpose : Urine proteomics is emerging as a powerful tool for biomarker discovery. The purpose of this study the development well‐characterized “real life” sample that can be used reference standard in urine clinical studies. Experimental design We report on generation male and female samples are extensively characterized by different platforms methods (CE‐MS, LC‐MS, LC‐MS/MS, 1‐D gel analysis combination with nano‐LC MS/MS (using LTQ‐FT ultra), 2‐DE‐MS) their proteome peptidome. In...
The gut microbiota was emerging as critical regulatory elements in shaping the outcome of cancer immunotherapy. However, underlying mechanisms by which commensal species enhance antitumor immunity remain largely unexplored. Here, we show that from healthy individuals conferred considerable sensitivity to anti-PD-1 colorectal (CRC) tumor-bearing mice, whereas CRC patients failed do so. By 16S rRNA gene sequencing, identified Lactobacillus significantly increased mice with good response...
Post-cholecystectomy diarrhea (PCD) is highly prevalent among outpatients with cholecystectomy, and gut microbiota alteration correlated it. However, how to what extent changed fecal bacteria contributes are still unrevealed. Humanized microbiome mice model by transplantation was established explore the diarrhea-inducible effects of microbiota. The role microbial bile acids (BAs) metabolites identified UPLC/MS underlying mechanisms were investigated selective inhibitors antagonists as...
ABSTRACT Background Immunoglobulin A nephropathy (IgAN) is a major cause of primary glomerulonephritis characterized by mesangial deposits galactose-deficient IgA1 (Gd-IgA1). Toll-like receptors (TLRs), particularly TLR4, are involved in the pathogenesis IgAN. The role gut microbiota on IgAN patients was recently investigated. However, whether microbial modifications Gd-IgA1 through TLR4 play remains unclear. Methods We recruited subjects into four groups, including 48 with untreated IgAN,...
The acidic (leucine‐rich) nuclear phosphoprotein 32 kDa (ANP32) family is composed of small, evolutionarily conserved proteins characterized by an N‐terminal leucine‐rich repeat domain and a C‐terminal low‐complexity region. mammalian members (ANP32A, ANP32B, ANP32E) are ascribed physiologically diverse functions including chromatin modification remodelling, apoptotic caspase modulation, protein phosphatase inhibition, as well regulation intracellular transport. In addition to reviewing the...
The major role of aldehyde dehydrogenase 2 family (ALDH2) is to detoxify acetaldehyde (ACE) non-toxic acetic acid. Many evidences suggest that ALDH2 dysfunction contributes a variety human diseases including cancer. However, the biological function and molecular mechanism in tumor progression remain elusive. In this study, we found repression was associated with poor prognosis lung adenocarcinoma. Overexpression inhibited malignant features adenocarcinoma cells, such as proliferation,...
Atherosclerosis is a chronic inflammatory metabolic disease with complex pathogenesis. However, the exact details of its pathogenesis are still unclear, which limits effective clinical treatment atherosclerosis. Recently, multiple studies have demonstrated that gut microbiota plays pivotal role in onset and progression This review discusses possible treatments for atherosclerosis using microbiome as an intervention target summarizes metabolites development New strategies needed. provides...
<i>Objective:</i> In order to improve the prognosis of pancreatic cancer patients, it is crucial explore novel tools for its early diagnosis. Here, we attempted screen serum biomarkers distinguish from non-cancer individuals. <i>Methods:</i> 47 samples 39 whom had small surgically resectable cancers, were collected before surgery, and an additional 53 age- sex-matched individuals without used as controls. The surface-enhanced laser desorption/ionization (SELDI)...
Hepatocellular carcinoma (HCC) develops in a complex microenvironment characterized by chronic inflammation. In recent years, cholesterol metabolic abnormalities have been implicated the importance cancer cell physiology. This study was designed to investigate relationship between inflammation and accumulation HCC cells. Human cells HepG2 Huh7 were cultured stimulated with lipopolysaccharide (LPS) for 24 h. The changes of related metabolism including intracellular concentrations, uptake,...
Although cardiac hypertrophy in hypertension has been well recognized, the molecular mechanisms for development of are still largely unknown. In this study, protein expression profiles left ventricular myocardia spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) at different ages were analyzed using 2-DE combination with MALDI-TOF/TOF MS/MS. The results showed that 20 proteins modulated hypertrophic myocardium. Out these proteins, 13 presented significant changes SHR an early stage...
Hypoxia-inducible factor-1 (HIF-1), consisting of oxygen-sensitive HIF-1alpha and constitutively expressed HIF-1beta subunits, is a master transcriptional activator for cellular response to hypoxia. To explore direct HIF-1 targets, here we used differential gel electrophoresis (DIGE) compare the HIF-1-regulated proteins between leukemic U937T-cell line with without conditional induction protein by tetracycline-off system. Among upregulated identified, mRNA levels annexin A1,...
The acidic leucine-rich nuclear phosphoprotein 32 (ANP32)B has been reported to regulate gene expression by acting as a histone chaperone or modulate messenger RNA trafficking serving HuR ligand. However, its exact cellular functions are poorly understood. By utilizing proteomics-based approach, in this work, we identify that the human ANP32B protein is cleaved during apoptosis induction NSC606985, novel camptothecin analog. Further investigation shows various inducers cause decrease of...
The pathophysiology of negative affect states in older adults is complex, and a host central nervous system peripheral systemic mechanisms may play primary or contributing roles. We conducted an unbiased analysis 146 plasma analytes multiplex biochemical biomarker study relation to number depressive symptoms endorsed by 566 participants the Alzheimer's Disease Neuroimaging Initiative (ADNI) at their baseline 1-year assessments. Analytes that were most highly associated with included...