A5101904036- RNA modifications and cancer
- Pancreatitis Pathology and Treatment
- Gastrointestinal motility and disorders
- Ferroptosis and cancer prognosis
- Gut microbiota and health
- Liver Disease Diagnosis and Treatment
- Protein Tyrosine Phosphatases
- Pancreatic and Hepatic Oncology Research
- Axon Guidance and Neuronal Signaling
- Kruppel-like factors research
- Ubiquitin and proteasome pathways
- Cell death mechanisms and regulation
- Cardiovascular Health and Risk Factors
- Urological Disorders and Treatments
- Autophagy in Disease and Therapy
- Surgical site infection prevention
- Nutritional Studies and Diet
- Advanced Computational Techniques and Applications
- Helicobacter pylori-related gastroenterology studies
- Genital Health and Disease
- Wnt/β-catenin signaling in development and cancer
- Urologic and reproductive health conditions
- Cancer-related molecular mechanisms research
- Abdominal vascular conditions and treatments
- Oxidative Organic Chemistry Reactions
Minhang District Central Hospital
2011-2025
Fudan University
2016-2025
Twelfth Guangzhou City People's Hospital
2008-2024
Hebei Medical University
2023
Second Hospital of Hebei Medical University
2023
Shandong University of Traditional Chinese Medicine
2022
Shanghai Municipal Commission of Health and Family Planning
2022
First Affiliated Hospital of Fujian Medical University
2019
Fujian Medical University
2016-2019
Zhongshan Hospital
2019
Post-cholecystectomy diarrhea (PCD) is highly prevalent among outpatients with cholecystectomy, and gut microbiota alteration correlated it. However, how to what extent changed fecal bacteria contributes are still unrevealed. Humanized microbiome mice model by transplantation was established explore the diarrhea-inducible effects of microbiota. The role microbial bile acids (BAs) metabolites identified UPLC/MS underlying mechanisms were investigated selective inhibitors antagonists as...
Post-cholecystectomy diarrhea (PCD) is a common complication of gallbladder removal, and gut microbiota changes have been determined in PCD patients. Bile acid (BAD) supposed to be the main pathogenic factor for due disrupted fecal bile metabolism diarrheal However, profiling metabolite alteration unclear whether changed are correlated also underdetermined. The metabolites from samples were profiled by targeted UPLC/MS (ultra-high-performance liquid chromatography coupled with...
Background: Considering the high likelihood of chronicity, it is imperative to understand risk factors and outcomes associated with severe anorexia nervosa (AN), for which Danish registers provide a unique opportunity. We developed measure AN severity adapted from clinical literature use in register-based research. Methods: The study population included all individuals born between 1963 2007 who were diagnosed 1969 2013. Using register data, we constructed Anorexia Nervosa Register-based...
// Rong-liang Shi 1,2,3,* , Qian Chen 1,* Zhen Yang 1 Gaofeng Pan Ziping Zhang WeiHua Wang 1,4 Shaoqun Liu Dongbin Daowen Jiang and Weiyan Department of General Surgery, Minhang Hospital, Fudan University, Shanghai, People’s Republic China 2 Head Neck University Shanghai Cancer Center, 3 Oncology, Medical College, 4 Thoracic * These authors have contributed equally to this work Correspondence to: Liu, email: Jiang, Keywords : gastric cancer, marital status, SEER,survival analysis...
Abstract: Melanoma is one of the deadliest skin cancers and accounts for most skin-related deaths due to strong resistance chemotherapy drugs. In present study, we investigated mechanisms dabrafenib-induced drug in human melanoma cell lines A375 MEL624. Our studies support that both endoplasmic reticulum (ER) stress autophagy were induced cells after treatment with dabrafenib. addition, ER stress-induced protects from toxicity Moreover, inhibition promote sensitivity Taken together, data...
A high body mass index (hBMI) is one of the major risk factors for ischemic stroke (IS), although independent estimates global burden and trend IS attributable to hBMI are unclear. Study data were extracted from Global Burden Diseases, Injuries, Risk Factors analysed by age, sex, year, geographical location. The sociodemographic (SDI) human development (HDI) used as indicators national socioeconomic status. Geographic distributions trends assessed calculating estimated annual percentage...
Compared to younger people, older people have a higher risk and poorer prognosis of acute pancreatitis, but the effect gut microbiota on pancreatitis is still unknown. We aim investigate aging explore potential mechanism this phenomenon.Eighteen fecal samples from healthy adult participants, including nine adults were collected. C57BL/6 mice treated with antibiotics for transplantation participants. Acute was induced by cerulein lipopolysaccharide in these mice. The aged further tested via...
Liver Hepatocellular Carcinoma (LIHC) is the fifth widely occurred carcinoma, which thought to be second primary contributor of carcinoma-associated death. There are almost 788,000 death tolls worldwide. Solute carrier family 41 member 3 (SLC41A3) a solute 41, and it key point numerous researches. Our research attempted explore links between SLC41A3 LIHC through public databases. Higher expression displayed an intimate association with higher pathological stages poorer prognosis. GO KEGG...
Asthma is an airway disease characterized by airflow limitation and various additional clinical manifestations. Repeated inflammatory stimulation of the airways leads to epithelial-mesenchymal transition (EMT) which aggravates subepithelial fibrosis during process remodelling enhances resistance corticosteroids bronchodilators in refractory asthma. There growing evidence that IL-27 modulates remodelling, however, molecular mechanisms involving EMT are poorly understood. The objective this...
Krüppel-like factor 4 (KLF4), a zinc-finger transcription in klfs family, is known for its crucial role regulating cell growth, proliferation, and differentiation. This research aimed to explore the prognostic significance of KLF4 hepatocellular carcinoma's (HCC) patients after curative resection HCC progression. There were 185 who had hepatectomy from July 2010 2011 included this study. expression was detected by microarray immunohistochemical technique, western blot, qRT-PCR. Then,...
The present study investigated the mechanism(s) of non‑alcoholic steatohepatitis‑related hepatocellular carcinoma (NASH‑HCC) developed from diabetes. Streptozotocin and a high‑fat diet (STZ‑HFD) were used to induce NASH‑HCC in ApoE‑/‑ mice. Mouse liver functions evaluated by H&E staining, liver/body weight serum biochemical analysis. expression levels inflammation‑associated factors determined RT‑qPCR. Gene profiles related molecular pathways examined principal component analysis, heatmap,...
Red blood cell distribution width (RDW) to human serum albumin (ALB) ratio (RDW/ALB Ratio, RAR) is a prognostic factor for adverse outcomes in different disease populations. However, the relationship between RAR and pulmonary embolism remains unclear. Therefore, this study set out investigate association risk of all-cause death acute (APE) patients admitted intensive care unit (ICU). This retrospective based on MIMIC-IV database. The primary outcome was mortality among with APE (in-hospital...
Talin1 is implicated in many cellular processes, which has been studied various diseases using molecular biological technology.
The management of acute pancreatitis (AP) remains a challenge to clinicians worldwide for limited effective interventions. Retinoid orphan receptor gamma t (RORγt) is therapeutic target several diseases; however, it unclear whether inhibiting RORγt can ameliorate AP. relative expression RORγt, IL-17 and IL-23 in the peripheral blood mononuclear cells AP patients was measured by RT-PCR. An mouse model induced ceruletide, SR1001 injected before ceruletide administration. RORγt+ cells, T helper...
With high incidence and mortality, severe acute pancreatitis (SAP) is an inflammatory disease of pancreas. When concurrent with systemic response syndrome (SIRS), multiple organ failure (MODS) or pancreatic encephalopathy (PE), it will significantly augment the mortal rate. Herein, we report first SAP case complicated fatal rupture cerebral aneurysm pre-existing arteriovenous malformation; meanwhile, numerous examinations indicated occurrence SIRS MODS. A 34-year-old male was admitted for...
Abstract Purpose The objective of this research was to investigate the potential mechanisms ALKBH5 in Liver Hepatocellular Carcinoma (LIHC). Methods We examined expression pan-cancer and its correlation with clinical factors LIHC. In vitro experiments were conducted verify LIHC effect on cell proficiency. Differentially expressed genes (DEGs) screened from patients associated ALKBH5, downstream identified by bioinformatics analysis. further constructed a prognostic nomogram. Lastly, we...
The objective of this research was to investigate the potential mechanisms AlkB homolog 5, RNA demethylase (ALKBH5) in hepatocellular carcinoma (HCC). We used Cancer Genome Atlas (TCGA), Kruskal-Wallis method and Kaplan-Meier (KM) survival analysis study expression ALKBH5 its correlation with clinical factors HCC. In vitro experiments verified effect on HCC cell phenotype. screened differentially expressed genes (DEGs) from patients associated ALKBH5. Through screening we identified...