A5044274597- Electrohydrodynamics and Fluid Dynamics
- Thermal properties of materials
- Immune Cell Function and Interaction
- Composite Material Mechanics
- Microgrid Control and Optimization
- Advanced Battery Technologies Research
- Aluminum Alloys Composites Properties
- Cellular and Composite Structures
- Graphene research and applications
- Circular RNAs in diseases
- Tribology and Wear Analysis
- Cancer-related molecular mechanisms research
- Image Processing Techniques and Applications
- Structural Behavior of Reinforced Concrete
- Advanced Cellulose Research Studies
- Plasma Diagnostics and Applications
- Magnetic and Electromagnetic Effects
- Structural Load-Bearing Analysis
- Simulation and Modeling Applications
- Hybrid Renewable Energy Systems
- CAR-T cell therapy research
- Immunotherapy and Immune Responses
- Polymer Foaming and Composites
- Animal Ecology and Behavior Studies
- Aerogels and thermal insulation
Northeast Forestry University
2023-2025
Qingdao University of Science and Technology
2024-2025
China Power Engineering Consulting Group (China)
2024
Second Hospital of Hebei Medical University
2023-2024
Hebei Medical University
2023-2024
Shanghai Jiao Tong University
2022-2024
Shanghai Innovative Research Center of Traditional Chinese Medicine
2024
Dalian Ocean University
2023
Jilian Technology Group (China)
2023
Shandong University
2014-2022
The clinical applications of immunocytokines are severely restricted by dose-limiting toxicities. To address this challenge, here we propose a next-generation immunocytokine concept involving the design LH05, tumor-conditional anti-PD-L1/interleukin-15 (IL-15) prodrug. LH05 innovatively masks IL-15 with steric hindrance, mitigating "cytokine sink" effect and reducing systemic toxicities associated wild-type anti-PD-L1/IL-15. Moreover, upon specific proteolytic cleavage within tumor...
Owing to its exceptional thermal conductivity, graphene demonstrates significant potential for enhancing heat transfer in rubber composites. However, the practical implementation of this application is substantially limited by interfacial resistance at graphene-rubber interfaces. This study systematically investigates transport characteristics composites containing four types noncovalently modified sheets (1-pyrenebutyl, 1-pyrenebutylamine, polybutyl acrylate, and polydopamine...
Due to its excellent thermal conductivity, graphene can have great potential in the conductivity of rubber composites. However, interfacial resistance between and severely hinders this application. In work, molecular dynamics methods were used study transport carboxylated, aminated, hydroxylated, oxy-bridged The results showed that covalently bonded modified significantly improved composites, with increases 156.56%, 86.83%, 60.71%, 44.28% decreases 41.84%, 34.72%, 31.86%, 16.74%,...
Developing universal CARs with improved flexible targeting and controllable activities is urgently needed. While several studies have suggested the potential of CD16a in tandem monoclonal antibodies to construct CAR-T cells, weak affinity between them one limiting factors for efficacy. Herein, we systematically investigated impact Fcγ receptor (FcγR) on cells properties by constructing using receptors different affinities IgG1 antibodies, namely CD16a, CD32a, CD64. We demonstrated that these...
The complete sequence of the mitochondrial genome mandarin vole (Lasiopodomys mandarinus) was completed and annotated in this study. circular is 16,375 bp length contains typical 37 genes that are arranged same order as putative ancestor vertebrate, 13 protein-coding genes, 22 tRNA 2 rRNA non-coding regions. This study will provide genetic resource to clarify taxonomic position genus Lasiopodomys.
Red blood cell distribution width (RDW) to human serum albumin (ALB) ratio (RDW/ALB Ratio, RAR) is a prognostic factor for adverse outcomes in different disease populations. However, the relationship between RAR and pulmonary embolism remains unclear. Therefore, this study set out investigate association risk of all-cause death acute (APE) patients admitted intensive care unit (ICU). This retrospective based on MIMIC-IV database. The primary outcome was mortality among with APE (in-hospital...
Abstract Wood ceramics using biomass materials as templates possess the benefits of facile fabrication and versatile applicability. To investigate physical properties, chemical properties microstructure wood prepared from materials, basic potential applications were expounded. In this paper, powder (WPWC) fiber (WFWC) through vacuum carbonization method, utilizing pine raw materials. The impact phenolic resin concentration mixture filling mass on various ceramics, including loss rate (MLR),...
Immunocytokines have demonstrated promising efficacy in preclinical studies, but their clinical applications are still limited by dose-related toxicities. To address the safety challenges of immunocytokines, here we propose a next-generation immunocytokine concept involving design tumor-conditional anti-PD-L1/IL-15 prodrug (LH05), which innovatively masks IL-15 with steric hindrance its flanking moieties. The successfully attenuated “cytokine sink” effect circulation and significantly...