A5100351936- Cancer Immunotherapy and Biomarkers
- Ferroptosis and cancer prognosis
- Atherosclerosis and Cardiovascular Diseases
- Telomeres, Telomerase, and Senescence
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Microtubule and mitosis dynamics
- Immune cells in cancer
- Prostate Cancer Treatment and Research
- Erythrocyte Function and Pathophysiology
- Epigenetics and DNA Methylation
- Histone Deacetylase Inhibitors Research
- Cancer Research and Treatments
- Lung Cancer Research Studies
- Inflammatory Biomarkers in Disease Prognosis
- Growth Hormone and Insulin-like Growth Factors
- Phagocytosis and Immune Regulation
- Cancer Mechanisms and Therapy
- Retinal and Optic Conditions
- RNA modifications and cancer
- MicroRNA in disease regulation
- Signaling Pathways in Disease
- Lung Cancer Treatments and Mutations
- T-cell and B-cell Immunology
- FOXO transcription factor regulation
Sichuan University
2023-2025
First Affiliated Hospital of Fujian Medical University
2024-2025
Fujian Medical University
2024-2025
West China Hospital of Sichuan University
2023-2025
University of Massachusetts Chan Medical School
2023-2024
Maternal and Child Health Hospital of Sichuan Province
2024
Chongqing Medical University
2024
The Affiliated Yongchuan Hospital of Chongqing Medical University
2024
University of Electronic Science and Technology of China
2024
Shanghai Changzheng Hospital
2024
Immune checkpoint inhibitors (ICIs) provide modest but unsatisfactory benefits for extensive-stage small cell lung cancer (ES-SCLC). Developing strategies treating ES-SCLC is critical.
Abstract Background Cholangiocarcinoma represents a malignant neoplasm originating from the hepatobiliary tree, with subset of tumors developing inside liver. Intrahepatic cholangiocarcinomas (ICC) commonly exhibit an asymptomatic presentation, rendering both diagnosis and treatment challenging. Cuproptosis, emerging regulated cell death pathway induced by copper ions, has garnered attention recently. As cancer cells show altered metabolism comparatively higher needs, cuproptosis may play...
Objectives Intimate partner violence (IPV) against women remains a major global public health problem with harmful consequences for individuals and society. People’s lifestyles have been greatly affected by the COVID-19 pandemic. This study investigated prevalence of relationship between IPV anxiety depression in pregnant Chinese during Design Cross-sectional study. Setting investigation was conducted Shenzhen City, Guangdong Province, China from 15 September to December 2020. Participants A...
Colorectal cancer (CRC) is a prevalent malignancy of the digestive tract. A new prognostic scoring model for colon adenocarcinoma (COAD) developed in this study based on genes involved tumor cell-mediated killing T cells (GSTTKs), accurately stratifying COAD patients, thus improving current status personalized treatment.
Background Diabetic foot ulcers (DFU), a frequent complication of the worldwide disease (diabetes), are primary causes amputations and early mortality. The development DFU is inseparably linked with inflammation nutrition, necessitating comprehensive evaluation their impact on risk. This study aimed to establish new predictive metric that integrated immune nutritional markers holistically assess risk development. Methods Data were sourced from NHANES, extracting participant 1999 2004....
Our previous research identified pathogenic variants in RetNet genes 23.4% of individuals with early-onset high myopia. This study aims to analyze the genetic defects patients myopia complicated by rhegmatogenous retinal detachment. Whole-exome sequencing was performed on 40 accompanied Variants were filtered from 281 genes, 178 related syndromic myopia, 23 non-syndromic myopia-associated and 29 detachment-related using a multistep bioinformatics approach. Clinical data collected for...
The introduction of PARP inhibitors (PARPis) and immune checkpoint (ICIs) has marked a significant shift in the treatment landscape for solid tumors. Emerging preclinical evidence initial clinical trials have indicated that synergistic application PARPis ICIs may enhance efficacy potentially improve long-term patient outcomes. Nonetheless, how to identify specific tumor types molecular subgroups most likely benefit from this combination remains an area ongoing research. This review...
Background Aryl hydrocarbon receptor nuclear translocator-like 2 (ARNTL2) belongs to the b HLH- PAS domain transcription factor family and is one of key clock genes that control circadian rhythm. ARNTL2 plays an important role in human biological functions. However, its various tumors, especially tumor immune microenvironment (TIME) immunotherapy, remains unclear. Methods We integrated data from cancer patients multiple databases, including Cancer Genome Atlas, Cell Lineage Encyclopedia,...
Neuronal intranuclear inclusion disease (NIID) is a rare progressive neurodegenerative disorder mainly caused by abnormally expanded GGC repeats within the NOTCH2NLC gene. Most patients with NIID show polyneuropathy. Here, we aim to investigate diagnostic electrophysiological markers of NIID.
Background Matrix metalloproteinase 14 (MMP14) is a member of the MMP family, which interacts with tissue inhibitors (TIMPs), and involved in normal physiological functions such as cell migration, invasion, metastasis, angiogenesis, proliferation, well tumor genesis progression. However, there has been lack relevant reports on effect MMP14 across cancers. This study aims to explore correlation between pan-cancer prognosis, immune infiltration, effects gene mismatch repair (MMR),...
Current immunotherapies are unsatisfactory against uveal melanoma (UM); however, elevated CD8+ T cell infiltration level indicates poor prognosis in UM. Here, we aimed to identify co-expressed gene networks promoting UM and created a prognostic hazard model based on the identified hub genes. Raw data clinical information were downloaded from The Cancer Genome Atlas (TCGA) Gene Expression Omnibus (GEO) databases. Stromal-immune comprehensive score (ESTIMATE) was used evaluate...
Abstract Grylloprimevala jilina Zhou & Ren is the third extant species of Grylloblattodea to be found in China. To understand various physiological functions sensilla on main sensory organs G. during its vital activities, this study used scanning electron microscopy examine morphology appendages and analyze their abundance distribution antennae. The filiform antennae comprise scape, pedicel flagellum. maxillary palps three segments, cerci contain four total. Altogether, 11...
<title>Abstract</title> <bold>Background</bold> Immune checkpoint inhibitors have been extensively utilized in treating breast cancer patients, leading to improved prognoses. For patients with negative responses, there is a pressing need identify alternative therapies improve outcomes. <bold>Method</bold> We used WGCNA muti-place metastasis samples find the lymph node related gene <italic>RFTN1</italic>. Consensus cluster show different subtype significant pathway changes and immune cells...
Immunocytokines have demonstrated promising efficacy in preclinical studies, but their clinical applications are still limited by dose-related toxicities. To address the safety challenges of immunocytokines, here we propose a next-generation immunocytokine concept involving design tumor-conditional anti-PD-L1/IL-15 prodrug (LH05), which innovatively masks IL-15 with steric hindrance its flanking moieties. The successfully attenuated “cytokine sink” effect circulation and significantly...
To compare the differences between involved-field irradiation (IFI) and elective nodal (ENI) in selecting optimal target area for neoadjuvant chemoradiotherapy (nCRT) patients with locally advanced esophageal squamous cell carcinoma (LA-ESCC).We retrospectively analyzed 267 LA-ESCC, of whom 165 underwent ENI 102 IFI. Dosimetry, treatment-related complications, pathological responses, recurrence/metastasis patterns, survival were compared two groups.The median follow-up duration was 27.9...