A5100454919- Glaucoma and retinal disorders
- Retinal Diseases and Treatments
- Corneal surgery and disorders
- Retinal Imaging and Analysis
- Ophthalmology and Visual Impairment Studies
- Ocular Diseases and Behçet’s Syndrome
- Ophthalmology and Eye Disorders
- Retinal Development and Disorders
- Intraocular Surgery and Lenses
- Retinal and Macular Surgery
- Corneal Surgery and Treatments
- Ocular Surface and Contact Lens
- Retinal and Optic Conditions
- S100 Proteins and Annexins
- Ocular Oncology and Treatments
- Neurological Disorders and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Ocular Infections and Treatments
- Ferroptosis and cancer prognosis
- Proteoglycans and glycosaminoglycans research
- Flavonoids in Medical Research
- Mitochondrial Function and Pathology
- Ocular Disorders and Treatments
- Mesenchymal stem cell research
- Facial Trauma and Fracture Management
Peking University Third Hospital
2016-2025
Beijing Tsinghua Chang Gung Hospital
2024-2025
Tsinghua University
2024-2025
Ningxia Medical University
2025
Peking University
2015-2024
Chinese PLA General Hospital
2024
Sun Yat-sen University
2023
Sichuan University
2023
West China Hospital of Sichuan University
2023
Beijing Anzhen Hospital
2022
A deep learning system (DLS) that could automatically detect glaucomatous optic neuropathy (GON) with high sensitivity and specificity expedite screening for GON.To establish a DLS detection of GON using retinal fundus images glaucoma diagnosis convoluted neural networks (GD-CNN) has the ability to be generalized across populations.In this cross-sectional study, classification was developed automated obtained from Chinese Glaucoma Study Alliance, Handan Eye Study, online databases. The...
This study aims to comprehensively evaluate the predictive accuracy of six widely used toric intraocular lens (IOL) calculators in eyes undergoing cataract surgery with IOL implantation. retrospective reviewed 53 patients that underwent extraction implantation using Zeiss 709 M. Six were evaluated: Barrett calculator (with predicted PCA, measured and TK), Kane formula (predicted PCA), EVO 2.0 PCA). Postoperative refractive astigmatism prediction errors calculated analyzed vector analysis....
Microglial activation is the initial pathological event that occurs in demyelination, a prevalent feature various neurological diseases. G protein-coupled estrogen receptor (GPER1), which highly expressed microglia, has been reported to reduce myelin damage. However, precise molecular mechanisms involved remain unclear. In this study, cuprizone (CPZ) -induced demyelination model was used investigate relationship between GPER1 and sheath injury its mechanism. The results demonstrated...
Background and Objective Tetrandrine (TET) is a bisbenzylisoquinoline alkaloid extracted from Stephania tetrandra Moore. Recent studies have suggested that TET can reduce the inflammatory response in microglia, but mechanisms remain unclear. The aim of this study to investigate whether inhibit lipopolysaccharide (LPS)-induced microglial activation clarify its possible mechanisms. Study Design/Materials Methods Cell viability assays cell apoptosis were used determine working concentrations...
The mechanistic study of glaucoma pathogenesis has shifted to seeking understand the effects immune responses on retinal ganglion cell damage and protection. Cytokines mediate biological system, our previous revealed an imbalance T-helper (Th) 1-derived Th2-derived cytokines in serum patients with glaucoma. In this study, we collected irises from normal individuals primary open-angle closure (POAG) or chronic angle-closure (CACG). We used real-time polymerase chain reaction (PCR) measure...
A noninvasive topical ocular therapy for the treatment of neovascular or "wet" age-related macular degeneration would provide a patient administered alternative to current standard care, which requires physician intravitreal injections. This manuscript describes novel strategy use in vivo models choroidal neovascularization (CNV) as primary means developing SAR related efficacy from administration. Ultimately, this effort led discovery acrizanib (LHA510), small-molecule VEGFR-2 inhibitor...
Glaucoma is the main cause of irreversible blindness worldwide. However, diagnosis and treatment glaucoma remain difficult because lack an effective grading measure. In this study, we aimed to propose artificial intelligence system provide adequate assessment patients. A total 16,356 visual fields (VFs) measured by Octopus perimeters Humphrey Field Analyzer (HFA) were collected, from three hospitals in China public Harvard database. We developed a fine-grained deep learning system, named...
Recent studies have suggested that bone marrow-derived mesenchymal stem cells (BMMSCs) are capable of retinal tissue-specific differentiation but not pigment epithelium (RPE) cell-specific differentiation. Photoreceptor outer segments (POS) contribute to RPE development and maturation. However, there has been no standard culture system fosters the BMMSCs into mature in vitro. In this study, we investigated if soluble factors from POS could differentiate having a phenotype characteristic...
Background and objective: Our objective was to investigate the efficacy safety of dexamethasone (DEX) implant for treatment pseudophakic cystoid macular edema (PCME) in diabetic patients. Study design: This a prospective, non-randomized, interventional case series 43 participants. Eighteen patients were enrolled DEX group 25 an intravitreal triamcinolone acetonide (IVTA) group. Main outcome measures: The primary measurement percentage who gained improvements more than ten letters best...
Objective: In this study, we aimed to investigate the frequency-dependent spontaneous neural activity in primary angle-closure glaucoma (PACG) using amplitude of low-frequency fluctuations (ALFF) method. Patients and methods: total, 52 PACG individuals (24 males 28 females) normal-sighted controls (NS; 24 who were closely matched age, sex, education underwent resting-state magnetic resonance imaging scans. A repeated-measures ANOVA post hoc two-sample t -tests conducted analyze different...
Objective This study aimed to investigate the prevalence of glaucoma with associated factors in rural populations 10 provinces China. Design A population-based cross-sectional study. Methods All participants aged 6 years or older from completed visual acuity testing, slit-lamp examination, ophthalmoscopy and non-contact tonometry. Glaucoma suspects underwent fundus photography, Goldmann applanation tonometry, field testing gonioscopy. was determined according International Society...
To compare the efficacy of topical tetrandrine (an alkaloid isolated from Chinese medicinal herb Radix Stephania tetrandrae S) and timolol 0.5% ophthalmic solution on lowering intraocular pressure (IOP) in ocular normotensive hypertensive rats.The experiment was designed as 2 parts. In first part, normal male Sprague-Dawley rats were divided into 4 groups followed by administration once 0.1%, 0.2%, 0.3% tetrandrine, right eye, 0.9% saline administered at opposite eye control. second...
Objective To investigate the prevalence of cataract-induced visual disability and its association with individual-level socioeconomic status (SES) among older adults in China. Methods Using data 354,743 (60 years older) from Second China National Sample Survey on Disability 2006. Cross-sectional study design was applied. The differences cataracts sociodemographic subgroups were analyzed by chi-square test, between SES investigated multivariate logistic regression model. Results weighted...
Abstract Background This study aimed to evaluate the visual and morphological outcomes of intravitreal anti-VEGF therapy recurrence for idiopathic choroidal neovascularization (ICNV). Methods retrospective included 35 patients (35 eyes) with ICNV from July 2012 October 2017. All received 1 injection followed by pro re nata injections until there was no sign activity. defined as first follow-up period. To recurrence, we continued 27 at least 2 years after initial diagnosis, longest period 5...
To evaluate patient-perceived quality of life with glaucoma and to assess whether ophthalmologists fully appreciate patients' perceptions through utility analysis.Utility values were obtained from 87 patients by linear rating scale (RS), standard gamble for blindness (SG), time trade-off (TTO) methods. Identical questionnaires delivered (n=26) at the same center, who asked assume they had mild (MD in better-seeing eye ≥-6 dB) or moderate severe <-6 glaucoma. Responses compared.Patients gave...
The aim of the project is to retrospectively study changes in bacterial pathogens acute neonatal conjunctivitis from 2002 2016 Southern China. results may provide guidance for drug choice conjunctivitis.Secretion specimens culture were taken 485 cases with clinically diagnosed conjunctivitis. Bacterial detected by Gram staining and subsequent culture.From analysis patients China, there an overall trend decreasing detection Gram-positive bacteria increasing Gram-negative conjunctival sac...