A5100755999- Liver Disease Diagnosis and Treatment
- Pregnancy and preeclampsia studies
- Liver Disease and Transplantation
- Hepatitis C virus research
- Birth, Development, and Health
- COVID-19 epidemiological studies
- SARS-CoV-2 and COVID-19 Research
- Reproductive System and Pregnancy
- Vaccine Coverage and Hesitancy
- Liver Diseases and Immunity
- Neurogenetic and Muscular Disorders Research
- Hepatitis B Virus Studies
- Amyotrophic Lateral Sclerosis Research
- Hepatocellular Carcinoma Treatment and Prognosis
- RNA Interference and Gene Delivery
- Alcohol Consumption and Health Effects
- Retinal Diseases and Treatments
- Gestational Diabetes Research and Management
- Artificial Intelligence in Healthcare
- Glaucoma and retinal disorders
- Plant Stress Responses and Tolerance
- Maternal and fetal healthcare
- Flavonoids in Medical Research
- Growth Hormone and Insulin-like Growth Factors
- Extracellular vesicles in disease
Guangdong Pharmaceutical University
2022-2024
Jiangsu University
2024
Harbin Medical University
2024
First Affiliated Hospital of Harbin Medical University
2024
Chinese University of Hong Kong
2021-2023
First Affiliated Hospital of Guangzhou Medical University
2023
Guangzhou Medical University
2023
Peking University Third Hospital
2019-2022
Peking University
2017-2022
Prince of Wales Hospital
2022
The COVID-19 pandemic has precipitated a global crisis, with more than 1,430,000 confirmed cases and 85,000 deaths globally as of 9 April 20201-4. Mitigation suppression new infections have emerged the two predominant public health control strategies5. Both strategies focus on reducing by limiting human-to-human interactions, which could be both socially economically unsustainable in long term. We developed analyzed an epidemiological intervention model that leverages serological tests6,7 to...
Antisense oligonucleotides (ASOs) were the first modality to pioneer targeted gene knockdown in treatment of amyotrophic lateral sclerosis (ALS) caused by mutant superoxide dismutase 1 (SOD1). RNA interference (RNAi) is another mechanism silencing which short interfering RNAs (siRNAs) effectively degrade complementary transcripts. However, delivery extrahepatic tissues like CNS has been a bottleneck clinical development RNAi. Herein, we identify potent siRNA duplexes for human SOD1 medicinal...
BackgroundLow-dose aspirin has been the most widely studied preventive drug for preeclampsia. However, guidelines differ considerably from country to regarding prophylactic use of There is limited evidence large trials determine effect 100 mg preeclampsia screening in women with high-risk pregnancies, based on maternal risk factors, and guide low-dose prevention China.ObjectiveThe Low-Dose Aspirin Prevention Preeclampsia China study was designed evaluate preventing among pregnant screened...
Background and Aims: It is unclear if the leading causes of death in patients with NAFLD differ by age. We aimed to investigate relative importance liver‐related deaths lower overshadowed cardiovascular cancer‐related elderly population. Approach Results: conducted a territory‐wide retrospective cohort study adult between 2000 2021 Hong Kong. The outcomes interest were all‐cause cause‐specific mortality. Age groups at studied 10‐year intervals. During 662,471 person‐years follow‐up 30,943...
We aimed to test the hypothesis that automated fibrosis score calculation and electronic reminder messages could increase detection of advanced liver disease in patients with type 2 diabetes.
Preeclampsia is a severe pregnancy-related disorder, and patients usually present with high circulating inflammatory factor levels excessive activation of the nuclear factor-κB (NF-κB) pathway. Administration aspirin (ASP) effective for preventing preeclampsia, thus, we propose that ASP might affect placental function by regulating NF-κB Systemic lipopolysaccharide (LPS) (20 μg/kg) was used to induce preeclampsia-like pregnant mouse model, low-dose (15.2 mg/kg) administrated. Here, report...
Abstract Pre‐eclampsia (PE) is a serious hypertensive disorder of pregnancy that remains leading cause perinatal and maternal morbidity mortality worldwide. Placental ischemia/hypoxia the secretion soluble fms‐like tyrosine kinase 1 (sFlt1) into circulation are involved in pathogenesis PE. Although low‐dose aspirin (LDA) has beneficial effects on prevention PE, exact mechanisms action LDA, particularly placental dysfunction, sFlt1 release, have not been well investigated. This study aimed to...
Summary Background Baveno VII was proposed for non‐invasive identification of clinically significant portal hypertension. However, a substantial proportion patients is classified in the grey zone ( i.e ., liver stiffness 15–24.9 kPa and/or platelet count <150 × 10 9 /L). Aims To evaluate risk and predictors hepatic decompensation zone, to determine prognostic role spleen measurement. Methods We included prospective cohorts (from Hong Kong, Korea France) who had undergone transient...
Summary Background Early screening may prevent fibrosis progression in metabolic‐associated fatty liver disease (MAFLD). Aims We developed and validated MAFLD score (MFS) for identifying advanced (≥F3) among patients. Methods This cross‐sectional, multicentre study consecutively recruited patients receiving tertiary care (Malaysia as training cohort [ n = 276] Hong Kong Wenzhou validation 431]). Patients completed biopsy, vibration‐controlled transient elastography (VCTE), clinical...
Decidual NK (dNK) cells, identified as CD56 bright CD16 − CD3 , account for ~70% of lymphocytes within the uterine wall during early pregnancy. Accumulating evidence suggests that tight interactions between placental trophoblasts and dNK cells are critical trophoblast cell differentiation. However, underlying mechanism remains to be explored in detail. In present study, conditioned medium (CM) was collected from cultured primary human cells. Primary cytotrophoblasts (CTBs) or line HTR8/SVneo...
Preeclampsia (PE), a placenta-associated pregnancy complication, is the leading cause of maternal and perinatal morbidity mortality. Met/Erk signaling inhibited in placentas patients with early-onset preeclampsia (E-PE), but underlying mechanisms remain elusive. In this study, expression modes Met endocytic vesicles normal preeclamptic were compared. Biotinylation internalization/recycling assays used to measure endocytosis under hypoxia normoxia HTR8/SVneo cells. addition, level Cbl,...
Abstract Background & Aims The steatosis‐associated fibrosis estimator (SAFE) score was developed to detect clinically significant liver in patients with NAFLD the United States. We compare performance of SAFE and other non‐invasive tests diagnose correlate scores liver‐related outcomes Hong Kong. Methods This a retrospective cohort study involving two data sets. first biopsy ( n = 279), second territory‐wide 4603) retrieved from electronic healthcare database Results In detecting...
Abstract Background & Aims aMAP score, as a hepatocellular carcinoma risk is proven to be associated with the degree of chronic hepatitis B‐related liver fibrosis. We aimed evaluate ability score for metabolic dysfunction‐associated steatotic disease (MASLD; formerly NAFLD)‐related fibrosis diagnosis and establish machine‐learning (ML) model improve diagnostic performance. Methods A total 946 biopsy‐proved MASLD patients from China United States were included in analysis. The...
Abstract: Glioblastoma is one of the most common malignant tumors in nervous system both adult and pediatric patients. Studies suggest that abnormal activation receptor tyrosine kinases contributes to pathological development glioblastoma. However, current therapies targeting kinase receptors have poor therapeutic outcomes. Here, we examined anticancer effects ponatinib, a multi-targeted inhibitor, on glioblastoma cells U87MG cell line mouse xenograft model. We showed ponatinib treatment...
The COVID-19 pandemic has precipitated a global crisis, with more than 690,000 confirmed cases and 33,000 deaths globally as of March 30, 2020 [1–4]. At present two central public health control strategies have emerged: mitigation suppression (e.g, [5]). Both focus on reducing new infections by interactions (and both raise questions sustainability long-term tactics). Complementary to those approaches, here we develop analyze an epidemiological intervention model that leverages serological...
The COVID-19 pandemic has precipitated a global crisis, with more than 690,000 confirmed cases and 33,000 deaths globally as of March 30, 2020 [1-4]. At present two central public health control strategies have emerged: mitigation suppression (e.g, [5]). Both focus on reducing new infections by interactions (and both raise questions sustainability long-term tactics). Complementary to those approaches, here we develop analyze an epidemiological intervention model that leverages serological...
Preeclampsia (PE) is a serious pregnancy-related disease, and patients usually present with high inflammatory response. Previous studies have suggested that aspirin (ASP) may role in alleviating the pathogenesis of preeclampsia. However, whether ASP can improve kidney damage mechanism for improving it currently unclear. Here we optimized lipopolysaccharide (LPS)-induced PE mouse model to identify renal protection. We found treatment ameliorated LPS-induced failure pathological changes,...