A5100710273- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Liver Disease and Transplantation
- Inflammatory mediators and NSAID effects
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Hepatitis C virus research
- Antiplatelet Therapy and Cardiovascular Diseases
- Cancer Mechanisms and Therapy
- Radiomics and Machine Learning in Medical Imaging
- Healthcare and Venom Research
- Pancreatic and Hepatic Oncology Research
- Liver physiology and pathology
- Renal cell carcinoma treatment
- Medical Research and Treatments
- Spinal Fractures and Fixation Techniques
- CAR-T cell therapy research
- Traditional Chinese Medicine Studies
- Cancer Research and Treatments
- Cardiovascular Disease and Adiposity
- Lipoproteins and Cardiovascular Health
- Blood Pressure and Hypertension Studies
- Spine and Intervertebral Disc Pathology
- Otitis Media and Relapsing Polychondritis
Peking University Cancer Hospital
2014-2025
Peking University
2010-2025
Yuhuangding Hospital
2024
Qingdao University
2024
University of North Carolina at Chapel Hill
2024
Binzhou Medical University
2024
Shanghai East Hospital
2015-2021
Wenzhou Medical University
2016-2021
Renji Hospital
2021
First Affiliated Hospital of Wenzhou Medical University
2016-2020
Background The prognosis of hepatocellular carcinoma (HCC) with major portal vein tumor thrombosis (PVTT) is dismal after standard treatment sorafenib. Hepatic arterial infusion chemotherapy (HAIC) has been suggested for patients HCC and PVTT. Purpose To compare the efficacy safety sorafenib plus 3cir-OFF HAIC versus alone advanced Materials Methods This phase II trial recruited systemic treatment-naïve PVTT (portal invasion grade Vp3 [first branch] Vp4 [main trunk]) between June 2017...
Background Wide interindividual variation in responses to cyclooxygenase (COX) inhibitory drugs limits their clinical utility and safety. Methods To better understand the molecular COX inhibition, we analyzed gene expression level of genes encoding enzymes related prostaglandin production including COX-1 (PTGS1) COX-2 (PTGS2), as well genetic polymorphisms, analgesic response such ibuprofen or rofecoxib placebo after minor surgery. Results Notable heterogeneity global was evident between...
Background and aim Imaging-confirmed non-alcoholic fatty liver disease (NAFLD) with normal alanine aminotransferase (nALT) levels is infrequently the subject for further evaluation. Early diagnosis of steatohepatitis (NASH) needed to prevent progression. Thus, we tested clinical utility serum Golgi protein 73 (GP73) developed a new non-invasive score diagnose NASH in patients biopsy-confirmed NAFLD persistent nALT levels. Methods Serum GP73 cytokeratin-18 M30 fragments (CK18-M30) were...
ABSTRACT Background Hepatocellular carcinoma (HCC) is the second leading cause of cancer‐related death in China. The rapid progress systemic therapies has led to approval many therapeutic methods that have quickly changed clinical guidelines and practices. Because high heterogeneity HCC, there are still some gaps between real‐world practice. present study surveyed experts China investigate current treatment concepts practice regarding HCC. Methods A questionnaire survey on HCC was...
Abstract Background & Aims aMAP score, as a hepatocellular carcinoma risk is proven to be associated with the degree of chronic hepatitis B‐related liver fibrosis. We aimed evaluate ability score for metabolic dysfunction‐associated steatotic disease (MASLD; formerly NAFLD)‐related fibrosis diagnosis and establish machine‐learning (ML) model improve diagnostic performance. Methods A total 946 biopsy‐proved MASLD patients from China United States were included in analysis. The...
Abstract Ewing sarcoma is a pediatric bone and soft tissue tumor treated with chemotherapy, radiation, surgery. Despite intensive multimodality therapy, ~50% patients eventually relapse die of the disease due to chemoresistance. Here, using phospho-profiling, we find cells chemotherapeutic agents activate TAM (TYRO3, AXL, MERTK) kinases augment Akt ERK signaling facilitating Mechanistically, chemotherapy-induced JAK1-SQ phosphorylation releases JAK1 pseudokinase domain inhibition allowing...
To investigate perioperative outcomes in patients undergoing modified laparoscopic splenectomy or open and azygoportal disconnection for portal hypertension.This study included 44 who underwent (MLSD) 71 procedures hypertension. Blood samples were collected before surgery on days 1, 3, 7 after surgery. Markers of liver renal function, C-reactive protein (CRP), interleukin-6 (IL-6), procalcitonin (PCT) measured, variables compared between the two groups.The group showed significantly better...
Intraoperative frozen pathology is critical when a breast tumor not diagnosed before surgery. However, tissues always present various microscopic morphologies, leading to high misdiagnose rate from section examination. Thus, we aimed identify tumors using bioimpedance spectroscopy (BIS), technology that measures the tissues' impedance. We collected and measured 976 specimens patients during surgery, including 581 cancers, 190 benign tumors, 205 normal mammary gland tissues. After...
Cyclooxygenase-2 (COX-2) and COX-2-derived prostaglandins contribute to acute inflammation pain, as well resolution of inflammation; inhibition COX-2 results in persistence inflammation. Because matrix metalloproteinases (MMPs) play an essential role inflammatory tissue injury their activity is regulated by prostaglandin E2, we evaluated whether associated with MMP overexpression during inflammation.A total 102 oral mucosal biopsy specimens were taken from 51 healthy volunteers who required...
Abstract Previous studies in other provinces of China (Beijing, Xinjiang, Shanxi, Jiangxi, Shanghai, Guangdong, and Taiwan) suggest that the distributions lymphoma subtypes differ compared with Western populations. In order to evaluate characteristics malignant Sichuan, China, we analyzed case series data from incident patients diagnosed 2008 three hospitals, including a total 1629 cases only current residents Sichuan. The median age diagnosis for was 54 years, higher proportion male female...
Using Southern blot, the restriction digests of genomic DNAs in 11 patients with Glanzmann thrombasthenia from 10 unrelated kindreds were probed a full-length GPIIb cDNA. An additional 2.3 kb Taq I fragment and two 1.65 0.65 fragments reduced band intensity found genes affected siblings family originating city Huang Yan Zhejiang province. The digest abnormal gene was further three portions cDNA, revealing that heterozygous mutation present region around exons 15-17 gene. Two primers for...
Study Design: A prospective cohort double-center study. Objective: To assess the clinical effect of minimally invasive transforaminal lumbar interbody fusion (miTLIF) using tunnel technique. Summary Background Data: series short-term studies have indicated that miTLIF could reduce blood loss and improve results. However, long-term study magnetic resonance imaging research are still scare. Methods: From January 2008 to 2009, 187 patients with 1-segment disease requiring intervertebral were...
To investigate accuracy of intraprocedural cone beam computed tomography (CBCT) compared to fluoroscopy for detection lipiodol retention pattern during conventional transarterial chemoembolization (cTACE) hepatocellular carcinoma (HCC) and its correlation with short-term response. Between September 2013 July 2014, 29 patients HCC underwent 51 tumors (mean diameter 28.1 mm, range 10.0–136.3 mm). Lipiodol was assessed by CBCT at the endpoint cTACE fluoroscopy. Depending on tumor covered three...
Abstract Background and Aim Determining individual risk of short‐term mortality in patients with acute‐on‐chronic hepatitis B liver failure (ACHBLF) is a difficult task. We aimed to develop externally validate prognostic nomogram for ACHBLF patients. Methods The was built estimate the probability 30‐day, 60‐day, 90‐day, 60‐month survival based on an internal cohort 246 ACHBLF. predictive accuracy discriminative ability were determined by concordance index (C‐index), calibration curve,...
OBJECTIVES: Chronic hepatitis B (CHB) can progress into liver fibrosis and cirrhosis with poor outcomes. Early accurate diagnosis of fibrosis/cirrhosis is important to guide the preventive strategy their related complications. METHODS: A Chinese multicenter cross-sectional study was conducted develop validate a novel noninvasive program for staging in untreated patients CHB. Liver histology evaluated independently by 2 pathologists. The alanine aminotransferase ratio, Hepascore, aspartate...
Transarterial chemoembolization (TACE) and hepatic arterial infusion chemotherapy (HAIC) have shown promising local benefits for advanced hepatocellular carcinoma (HCC). S-1, a composite preparation of 5-fluorouracil prodrug, has proven to be convenient oral chemotherapeutic agent with definite efficacy against HCC.To evaluate the safety TACE followed by HAIC or without S-1 treating HCC.In this single-center, open-label, prospective, randomized controlled trial, 117 participants HCC were...
Abstract Objective: To investigate the prognostic factors in chemorefractory colorectal cancer liver metastasis (CRCLM) patients treated by transarterial chemoembolization (TACE) and sustained hepatic arterial infusion chemotherapy (HAIC). Methods: Between 2006 2015, 162 who underwent 763 TACE HAIC total were enrolled this retrospective study, including 110 males 52 females, with a median age of 60 (range, 26−83) years. Prognostic assessed Log-rank test, Cox univariate multivariate analyses....
Background Pulmonary lipiodol embolism after transarterial chemoembolization (TACE) was rare and life-threatening, occasionally reported in previous literatures. We aimed to review the records of 11 patients with pulmonary oily analyze their characteristics radiographic findings risk factors. Methods Records 478 consecutive who underwent 1 026 percutaneous TACE procedures were retrospectively analyzed. Eleven cases respiratory symptoms identified as having symptomatic TACE. Data these...
COL17A1 (collagen type XVII alpha 1 chain) is known to be upregulated and has a prognostic role in many malignancies, as well contributing cell proliferation, apoptosis, invasion. However, little knowledge available on the expression value of pancreatic adenocarcinoma (PDAC). In our study, we searched public database found that mRNA protein levels are commonly PDAC tissues. The immunohistochemical analysis conducted by us revealed enhanced 169 samples compared with 67 adjacent normal We also...