A5086672546- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Liver Disease and Transplantation
- Alcohol Consumption and Health Effects
- Drug-Induced Hepatotoxicity and Protection
- Hepatocellular Carcinoma Treatment and Prognosis
- Drug Transport and Resistance Mechanisms
- Hepatitis Viruses Studies and Epidemiology
- HIV/AIDS drug development and treatment
- Pancreatitis Pathology and Treatment
- SARS-CoV-2 and COVID-19 Research
- Nutrition and Health in Aging
- Substance Abuse Treatment and Outcomes
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Food Security and Health in Diverse Populations
- Immune Cell Function and Interaction
- Diabetes Treatment and Management
- Allergic Rhinitis and Sensitization
- Cancer Immunotherapy and Biomarkers
- HIV-related health complications and treatments
- Diet, Metabolism, and Disease
- Liver Diseases and Immunity
- Systemic Lupus Erythematosus Research
- Diabetes Management and Research
Chinese University of Hong Kong
2019-2025
Therapeutics Clinical Research
2022
Prince of Wales Hospital
2021
Microtest (United Kingdom)
2015
Angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) can inhibit liver fibrogenesis in animal models. We aimed to evaluate the impact of ACEI/ARB use on risk cancer cirrhosis complications patients with NAFLD.We conducted a retrospective, territory-wide cohort study adult NAFLD diagnosed between January 2000 December 2014 allow for at least 5 years follow-up. ACEI or ARB users were defined as who had received treatment 6 months. The primary endpoint was...
Accurate hepatocellular carcinoma (HCC) risk prediction facilitates appropriate surveillance strategy and reduces cancer mortality. We aimed to derive validate novel machine learning models predict HCC in a territory-wide cohort of patients with chronic viral hepatitis (CVH) using data from the Hospital Authority Data Collaboration Lab (HADCL).This was territory-wide, retrospective, observational, study CVH Hong Kong 2000-2018 identified HADCL based on markers, diagnosis codes, antiviral...
Abstract Background and Aims Several guidelines recommend screening for NAFLD in patients with type 2 diabetes (T2D). We aimed to determine if there is a threshold of age duration T2D liver‐related event development guide strategies. Approach Results conducted territory‐wide retrospective cohort study adult diagnosed between 2000 2014 Hong Kong allow at least 5 years follow‐up. The primary endpoint was events, defined as composite HCC cirrhotic complications. This included 7028 (mean age,...
Patients with chronic hepatitis B (CHB) are aging because of improved survival under better health care. This has an important implication on the choice antiviral treatment (AVT), given that long‐term safety would be a concern in presence multiple comorbidities. We aimed to determine prevalence key comorbidities and concomitant medications territory‐wide CHB cohort Hong Kong 2000‐2017. patients who have been care at primary, secondary, tertiary medical centers public sector were identified...
We compared risk of acute liver injury and mortality in patients with COVID-19 current, past, no HBV infection.This was a territory-wide retrospective cohort study Hong Kong. Patients between January 23, 2020, 1, 2021, were identified. hepatitis C or HBsAg results excluded. The primary outcome mortality. Acute defined as alanine aminotransferase aspartate ≥2 × upper limit normal (ULN; i.e., 80 U/L), total bilirubin ULN (i.e., 2.2 mg/dL) and/or international normalized ratio ≥1.7. Of 5,639...
INTRODUCTION: Immunotherapy has dramatically improved the survival of patients with advanced or metastatic malignancies. Recent studies suggest that immunotherapy may increase risk hepatitis, whereas it also induce functional cure chronic hepatitis B virus (HBV) infection. We evaluated incidence flare, HBV reactivation, surface antigen (HBsAg) seroclearance seroreversion in current past infection who had received immunotherapy. METHODS: This was a territory-wide observational cohort study...
Summary Background Universal vaccination of newborns with hepatitis B virus (HBV) vaccine is the most important strategy to prevent chronic HBV infection and its complications which hepatocellular carcinoma (HCC) as deadliest. Aims To evaluate impact universal on prevalence infection, incidences HCC hepatic events in young adults born before after introduction programme 1988 Hong Kong Methods This was a territory‐wide retrospective observational cohort study consecutive adult subjects...
Background and Aims: It is unclear if the leading causes of death in patients with NAFLD differ by age. We aimed to investigate relative importance liver‐related deaths lower overshadowed cardiovascular cancer‐related elderly population. Approach Results: conducted a territory‐wide retrospective cohort study adult between 2000 2021 Hong Kong. The outcomes interest were all‐cause cause‐specific mortality. Age groups at studied 10‐year intervals. During 662,471 person‐years follow‐up 30,943...
The latest Baveno VII consensus has provided guidance for identifying patients who have truly recompensated from those with hepatic decompensation. This study aimed to evaluate patients' transplant-free survival in three different stages of cirrhosis.All chronic HBV infection and liver cirrhosis treated oral nucleos(t)ide analogues March 2006 December 2022 were identified a territory-wide database Hong Kong. Patients follow-up duration <1 year excluded. Participants classified into mutually...
Microarray platforms, enabling simultaneous measurement of many allergens with a small serum sample, are potentially powerful tools in allergy diagnostics. We report here the first study comparing fully automated microarray system, Microtest manual platform, Immuno-Solid phase Allergen Chip (ISAC), and two well-established singleplex tests, skin prick test (SPT) ImmunoCAP, all tested on same patients. One hundred three adult allergic patients attending clinic were included into study. All...
Abstract Background and Aim Male sex is a risk factor for hepatocellular carcinoma (HCC). Diabetes mellitus (DM) associated with doubled of HCC in patients chronic hepatitis B (CHB). We examined the relationship between serum total testosterone male CHB DM. Methods performed retrospective cohort study DM 2000 2017 using territory‐wide electronic health‐care database Hong Kong. was defined by use anti‐diabetic medications, hemoglobin A 1c ≥ 6.5%, and/or fasting glucose 7 mmol/L two...
Antiviral treatment is known to improve survival in patients with chronic hepatitis B (CHB)-related hepatocellular carcinoma (HCC). Yet, the uptake CHB remains low. We aimed report secular trend antiviral from 2007-2017, and compare effect of different nucleos(t)ide analogue (NA) initiation times (before vs. after HCC diagnosis) on survival. A 3-month landmark analysis was used overall not receiving NA (i.e. no NA), NAs their first post-HCC ≤3 months before pre-HCC NA). propensity...
ABSTRACT Purpose Recent research (Li et al. 2021) suggests an upregulated expression and activation of H1 receptors on macrophages in the tumor microenvironment, concomitant H1‐antihistamine use is associated with improved overall survival patients lung skin cancers receiving immunotherapy. Therefore, we retrospectively evaluated impacts cancer during Methods All who had received at least one dose immune checkpoint inhibitors (ICIs) from July 1, 2014 to October 31, 2019 were identified Hong...
Background & Aims: The outcomes and benefits of antiviral therapy in patients with indeterminate phase HBeAg-negative chronic hepatitis B (CHB) are not well described treatment guidelines. We examined hepatocellular carcinoma (HCC) risk among these patients. Approach Results: identified all non-cirrhotic treatment-naïve CHB who received ≥1 test for virus (HBV) DNA HBeAg. included abnormal alanine aminotransferase (ALT ≥40 IU/L) low HBV (<2,000 IU/mL), or normal ALT (<40 high...
It is unknown whether patients with chronic hepatitis B (CHB) who achieved surface antigen (HBsAg) seroclearance spontaneously or following anti-viral therapy have similar clinical outcomes.To compare the risk of hepatocellular carcinoma (HCC) in CHB either cleared HBsAg METHODS: Adult CHB-monoinfected between January 2000 and March 2019 were identified from a territory-wide database Hong Kong. Patients liver transplantation and/or HCC before loss excluded. Patients' demographics,...
Aspirin may reduce the risk of chronic hepatitis B (CHB)-related hepatocellular carcinoma (HCC) in patients receiving antiviral treatment. We aimed to investigate impact aspirin on reducing HCC treated with first-line oral nucleos(t)ide analogs (NAs; entecavir and/or tenofovir disoproxil fumarate).We conducted a territorywide, retrospective cohort study NA-treated CHB between 2000 and 2018 from electronic healthcare data repository Hong Kong. Subjects were classified into users for at least...
We aimed to determine the association between blood urea level and incident cirrhosis, hepatic decompensation, hepatocellular carcinoma in chronic liver disease (CLD) patients.The fibrosis/liver-related events were evaluated on continuous scale with restricted cubic spline curves based generalized additive model or Cox proportional hazards models. Then, above associations by within intervals.Among 4,282 patients who had undergone stiffness measurement (LSM) transient elastography, baseline a...
Background and Aims: We aimed to determine the impact of duration type 2 diabetes (T2D) on risk liver-related events all-cause mortality in patients with NAFLD. Approach Results: conducted a territory-wide cohort study adult NAFLD diagnosed between January 1, 2000, July 31, 2021, Hong Kong. T2D was defined by use any antidiabetic agents, laboratory tests, and/or diagnosis codes. The primary endpoint events, as composite HCC cirrhotic complications. To conduct more granular assessment T2D, we...
Abstract Thiazolidinediones (TZDs) improve glycaemic control and ameliorate liver steatosis, inflammation fibrosis in patients with fatty disease. We aimed to study the impact of TZD on risk hepatocellular carcinoma (HCC) hepatic events diabetic chronic hepatitis B (CHB). performed a retrospective cohort CHB 2000‐2017 using territory‐wide electronic healthcare database Hong Kong. Diabetes mellitus was identified by use any antidiabetic medication, haemoglobin A 1c (HbA ) ≥6.5%, fasting...