A5027377410- Retinal Diseases and Treatments
- Adrenal and Paraganglionic Tumors
- Hormonal Regulation and Hypertension
- Glaucoma and retinal disorders
- Pituitary Gland Disorders and Treatments
- Retinal Development and Disorders
- Lipoproteins and Cardiovascular Health
- Adipokines, Inflammation, and Metabolic Diseases
- BRCA gene mutations in cancer
- Retinal and Optic Conditions
- Cardiovascular Function and Risk Factors
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiomyopathy and Myosin Studies
- Ocular Diseases and Behçet’s Syndrome
- Cancer, Hypoxia, and Metabolism
- Cardiac Imaging and Diagnostics
- Cardiac Fibrosis and Remodeling
- Cardiovascular Health and Risk Factors
- Aortic aneurysm repair treatments
- Retinal Imaging and Analysis
- Connective tissue disorders research
- Chronic Disease Management Strategies
- Stroke Rehabilitation and Recovery
- Psoriasis: Treatment and Pathogenesis
- Flavonoids in Medical Research
Chinese Academy of Medical Sciences & Peking Union Medical College
2006-2025
Mudanjiang Medical University
2025
RMIT University
2017-2024
Capital Medical University
2024
Beijing Chao-Yang Hospital
2024
China-Japan Friendship Hospital
2024
Fu Wai Hospital
2023
Peking Union Medical College Hospital
2015-2022
China Medical University
2022
Peking University Third Hospital
2009-2020
Abstract Background Recent studies have suggested that insulin resistance (IR) contributes to the development of cardiovascular diseases (CVD), and estimated glucose disposal rate (eGDR) is considered be a reliable surrogate marker IR. However, most existing evidence stems from involving diabetic patients, potentially overstating effects eGDR on CVD. Therefore, primary objective this study examine relationship with incidence CVD in non-diabetic participants. Method The current analysis...
purpose. This study was designed to elucidate the role of inflammatory process in diabetic retinopathy and investigate effect baicalein treatment on rat. methods. Retinal microglial cells were identified with CD11b antibody, retinal Müller glial fibrillary acidic protein (GFAP). The gene expression interleukin (IL)-18, tumor necrosis factor (TNF)-α, IL-1β examined by quantitative real-time PCR. GFAP vascular endothelial growth (VEGF) PCR, immunohistochemistry, Western blot analysis....
Insulin resistance (IR) has been confirmed that getting involved in the pathophysiological process of cardiovascular diseases (CVD). Recently, increasing evidence suggests metabolic score for insulin (METS-IR), triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio, and glucose (TyG) index, glucose-body mass (TyG-BMI) index are simple reliable surrogates IR. However, their abilities predicting outcomes patients undergoing percutaneous coronary intervention (PCI) not well...
Abstract Background Abdominal obesity has long been considered as a crucial risk factor of stroke. Chinese visceral adiposity index (CVAI), novel surrogate indicator abdominal obesity, confirmed better predictor for coronary heart disease than other indicators in Asian population. However, the data on relationship CVAI with stroke is limited. The objective our study evaluating between and incidence. Methods In present study, we enrolled 7242 middle-aged elderly residents from China Health...
Some clinical trials have validated a new perspective on continuous renal replacement therapy (CRRT) in combination with oXiris haemofilter to more effectively enhance endotoxins clearance and circulating cytokines adsorption, stabilise vital signs, correct haemodynamic disorders accelerate the recovery of organ function, thus providing survival benefits. However, no such mode has been reported paediatric patients sodium valproate (SV)-induced acute pancreatitis (AP). An early childhood boy...
Abstract Importance Inherited retinal dystrophies (IRDs) are a group of monogenic diseases, one the leading causes blindness. Background Introducing comprehensive genetic testing strategy by combining single gene Sanger sequencing, next‐generation sequencing (NGS) including whole exome (WES), and specific hereditary eye disease enrichment panel (HEDEP) to identify disease‐causing variants 800 Chinese probands affected with non‐syndromic IRDs. Design Retrospective analysis. Participants Eight...
Bullying is a recognised problem in nursing. Nursing students are particularly vulnerable. and harassment of nursing can be detrimental to both recipients care. This study aims identify the incidence nature bullying and/or experienced by Sri Lanka. A cross-sectional survey consisting eight demographic questions 15 items specific experience was administered online. total 656 from 26 education institutions Lanka participated. The majority were female with mean age 24.4 years. More than quarter...
The relationship between depression and cardiovascular disease (CVD) in individuals with prediabetes, its relative importance compared traditional risk factors whether genetic modifies this association remain unclear. To explore the potential interactive effects of controlling on CVD, to assess how compares terms contribution CVD prediabetes. We analysed a prospective cohort 42,020 from UK Biobank, all free prevalent CVD. Depression was determined using multiple sources accurately exposure....
Abstract Purpose Registered nurses and midwives require a degree of genomic literacy if they are to adequately communicate with other healthcare professionals provide optimal care patients, their families, the community. Several studies have been conducted internationally assess nurses; however, Australian registered has not investigated. The aim this study was measure through assessing participants’ understandings concepts most critical nursing midwifery practice, as well perceived...
Professional identity and self-efficacy are important for the education career development of students. However, how to improve these factors among Chinese nursing students needs further study. This quasi-randomized control trial was designed explore effect medical documentaries on professional in technical schools.A total 277 were enrolled this study divided into an experimental group (n = 135) a 142). The invited watch documentaries, whereas remained waiting list. A self-designed general...
AIM: To assess quantitative changes of the macula in diabetic eyes after cataract surgery using optical coherence tomography (OCT) and to estimate incidence development or worsening macular edema (ME) with without pre-existing ME. METHODS: In this prospective, observational study, 92 60 patients who underwent were evaluated before 1, 3mo OCT. Macular thickness was measured OCT at nine subfields defined by 9 zones early treatment retinopathy study (ETDRS), as well total volume obtained...
Abstract Background The association between the triglyceride-glucose (TyG) index and clinical outcomes in patients with both coronary artery disease (CAD) psoriasis is unclear. This study investigated TyG major adverse cardiovascular events (MACE) CAD psoriasis. Methods retrospective cohort included diagnosed who underwent angiography at Fuwai Hospital, Beijing, China, January 2017 May 2022. endpoint was occurrence of MACE or end follow-up time. Multivariate Cox proportional analysis...
Retinitis pigmentosa (RP) is the most common inherited retinal disease. It a clinically and genetically heterogeneous disorder, which why it particularly challenging to diagnose. The aim of this study was establish targeted next-generation sequencing (NGS) approach for comprehensive, rapid, cost-effective clinical molecular diagnosis RP. A specific hereditary eye disease enrichment panel (HEDEP) based on exome capture technology used collect protein coding regions 371 genes, followed by...
Abstract Background This study aimed to evaluate the visual and morphological outcomes of intravitreal anti-VEGF therapy recurrence for idiopathic choroidal neovascularization (ICNV). Methods retrospective included 35 patients (35 eyes) with ICNV from July 2012 October 2017. All received 1 injection followed by pro re nata injections until there was no sign activity. defined as first follow-up period. To recurrence, we continued 27 at least 2 years after initial diagnosis, longest period 5...
To determine potential risk factors that could predict stress fractures over an 8-week basic military training in Chinese male infantry recruits.Recruits from three units enrolled this prospective study. At baseline, demographic data, personal history of fractures, mean duration weekly exercise and smoking were recorded on questionnaires blood samples taken for analysis bone turnover biomarkers genetic factors.Of the 1516 recruits who volunteered to participate study, 1398 provided data...
Aim: Smoking is a major risk factor for abdominal aortic aneurysm (AAA). Among the components of smoke, nicotine known to exert proatherosclerotic, prothrombotic and proangiogenic effects on vascular smooth cells. The current study was designed investigate mechanisms by which induces wall dysfunction further examine whether melatonin could protect against nicotine-related AAA. Methods: In this study, an enzyme-linked immunosorbent assay (ELISA) used measure TNF-α levels total antioxidant...
Background Catecholamine excess arising from pheochromocytomas and paragangliomas (PPGLs) can cause a wide spectrum of cardiac manifestations. Although there are reviews reported cases, these lack detailed data, which makes it impossible to perform an accurate analysis. In this study, we conducted comprehensive analysis cardiovascular complications (CCs), including PPGL-related myocardial injury, cardiogenic shock, arrhythmias requiring antiarrhythmic therapy, in large cohort patients with...
purpose. To investigate whether autologous retinal pigment epithelium (RPE) and a partial-thickness graft can repair degenerated photoreceptors overlying mechanically damaged Bruch’s membrane. methods. Twenty-one pigmented rabbits were used in the study. Abrasive debridement of RPE was performed with metal cannula after superior bleb detachment 20 rabbits. The prepared beneath inferior retina transplanted to area 14 days later. Debridement-only sites served as control. Tissue sections...