A5102967507- Aquaculture disease management and microbiota
- Neuroinflammation and Neurodegeneration Mechanisms
- Coal and Its By-products
- Recycling and utilization of industrial and municipal waste in materials production
- Machine Learning in Materials Science
- Invertebrate Immune Response Mechanisms
- Immune Cell Function and Interaction
- Retinal Development and Disorders
- Topic Modeling
- Computational Drug Discovery Methods
- Magnesium Alloys: Properties and Applications
- Environmental Changes in China
- Natural product bioactivities and synthesis
- Aluminum Alloys Composites Properties
- Cholesterol and Lipid Metabolism
- Microstructure and mechanical properties
- Advanced biosensing and bioanalysis techniques
- Geoscience and Mining Technology
- Immune cells in cancer
- Cancer Research and Treatments
- Nuclear materials and radiation effects
- Single-cell and spatial transcriptomics
- Antioxidant Activity and Oxidative Stress
- Retinal Diseases and Treatments
- Biomedical and Engineering Education
Zhejiang University
2022-2025
Shandong Freshwater Fisheries Research Institute
2018-2024
Zhejiang University of Technology
2023-2024
BeiGene (China)
2024
Southeast University
2023
North University of China
2020-2023
Southwest Jiaotong University
2023
Second Hospital of Shandong University
2022
Institute of Soil Science
2021
Chinese Academy of Sciences
2021
Abstract Uncovering the tissue molecular architecture at single-cell resolution could help better understand organisms’ biological and pathological processes. However, bulk RNA-seq can only measure gene expression in cell mixtures, without revealing transcriptional heterogeneity spatial patterns of single cells. Herein, we introduce Bulk2Space ( https://github.com/ZJUFanLab/bulk2space ), a deep learning framework-based deconvolution algorithm that simultaneously disclose cellular data using...
Large Language Models (LLMs) have emerged as a transformative power in enhancing natural language comprehension, representing significant stride toward artificial general intelligence. The application of LLMs extends beyond conventional linguistic boundaries, encompassing specialized systems developed within various scientific disciplines. This growing interest has led to the advent LLMs, novel subclass specifically engineered for facilitating discovery. As burgeoning area community AI...
The rapid advancement of large language models is reshaping research across various fields, offering a novel approach to the complex realm molecular studies. Our evaluation GPT-4 and GPT-3.5, focusing on their performance in generating optimizing structures, highlights GPT-4's strengths certain aspects optimization. However, it also revealed challenges accurately creating molecules. Addressing these issues, we propose possible directions for future science research. These suggestions aim...
Bietti crystalline corneoretinal dystrophy is an inherited retinal disease caused by mutations in CYP4V2, which results blindness the working-age population, and there currently no available treatment. Here, we report of first-in-human clinical trial (NCT04722107) gene therapy for dystrophy, including 12 participants who were followed up 180-365 days. This open-label, single-arm exploratory aimed to assess safety efficacy a recombinant adeno-associated-virus-serotype-2/8 vector encoding...
Osteoarthritis (OA) is a chronic arthritic disease that causes the overproduction of inflammatory factors such as nitric oxide (NO). This study develops NO nanosensor to predict OA development. The synthesized by encapsulating sensing molecules (i.e., 4-amino-5-methylamino-2',7'-difluorofluorescein Diaminofluorescein-FM (DAF-FM)) within biodegradable poly(lactic-co-glycolic acid) nanoparticles. In vitro, allows monitoring release in interleukin-1β-stimulated chondrocytes and alleviated...
Abstract Bietti crystalline corneoretinal dystrophy (BCD) is an autosomal recessive chorioretinal degenerative disease without approved therapeutic drugs. It caused by mutations in CYP4V2 gene, and about 80% of BCD patients carry exon 7 to 11. Here, we apply CRISPR/Cas9 mediated homology-independent targeted integration (HITI)-based gene editing therapy HEK293T cells, patient derived iPSCs, humanized Cyp4v3 mouse model ( h-Cyp4v3 mut/mut ) using two rAAV2/8 vectors via sub-retinal...
The composite or hybrid of organic and inorganic materials is one the common ways to improve properties photoelectric functional materials. Perylene bisimide (PBI) derivatives, as large π-conjugated small molecules, are a class with excellent performance. However, there were few reports on PBIs in electrochromic field due difficulty film-forming caused by their generally poor solubility. Here, water-soluble PBI derivatives (PDI-COOH PCl-COOH) synthesized. films (ZnO@PDI-COOH/PCl-COOH) formed...
Owing to the high Ca content but low concentration of Si and Al in fly ash (FA) generated from municipal solid waste incineration (MSWI), hydrothermal treatment (HT) MSWI FA directly could not result synthesis calcium-containing aluminosilicate minerals zeolites such as tobermorite, an important material for solidification heavy metals. According research results effect extra silicon–aluminum source added, with higher amount (30%) composite additive which ratio quality coal (CFA) diatomite...
Cyclooxygenase (COX)-2, a multi-functional molecule, is overexpressed in hepatocellular carcinomas. In order to understand cell proliferation and its association with COX-2 HepG2 cells the presence of ursolic acid (UA), viili exopolysaccharides (VEPS) Astragalus polysaccharides (APS), proliferation, superoxide dismutase (SOD) metabolic malondialdehyde (MDA) fatty acids, COX-2, prostaglandin E2 (PGE2), as well apoptotic morphology rate were investigated. The results revealed that activities...
Retinitis pigmentosa (RP) is the most common inherited retinal disease. It a clinically and genetically heterogeneous disorder, which why it particularly challenging to diagnose. The aim of this study was establish targeted next-generation sequencing (NGS) approach for comprehensive, rapid, cost-effective clinical molecular diagnosis RP. A specific hereditary eye disease enrichment panel (HEDEP) based on exome capture technology used collect protein coding regions 371 genes, followed by...
The immunoglobulins (Ig) and polymeric immunoglobulin receptor (pIgR) are crucial in protecting organisms against pathogen invasion. However, further clarification regarding their mucosal immune responses is required, particularly when considering various vaccine administration routes. Herein, polyclonal antibodies largemouth bass (Micropterus salmoides) recombinant pIgR IgM were prepared, respectively. Moreover, response features investigated after immunization via bath intraperitoneal...