A5100766076- HER2/EGFR in Cancer Research
- CAR-T cell therapy research
- Genetics and Neurodevelopmental Disorders
- Monoclonal and Polyclonal Antibodies Research
- Malaria Research and Control
- Adipose Tissue and Metabolism
- Folate and B Vitamins Research
- Knowledge Management and Sharing
- Transplantation: Methods and Outcomes
- Pressure Ulcer Prevention and Management
- Cancer Immunotherapy and Biomarkers
- Global Cancer Incidence and Screening
- Colorectal and Anal Carcinomas
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Protein Degradation and Inhibitors
- Family and Disability Support Research
- Histone Deacetylase Inhibitors Research
- Functional Brain Connectivity Studies
- Drug Transport and Resistance Mechanisms
- Diabetic Foot Ulcer Assessment and Management
- Team Dynamics and Performance
- Acute Lymphoblastic Leukemia research
- Estrogen and related hormone effects
- Growth Hormone and Insulin-like Growth Factors
Lanzhou University Second Hospital
2024
Shanxi Medical University
2024
Shanghai Pulmonary Hospital
2024
Tongji University
2023-2024
Shanxi Academy of Medical Sciences
2024
Shanghai Cell Therapy Research Institute
2024
Lanzhou University
2024
Changsha University of Science and Technology
2024
Zhejiang University
2024
People's Liberation Army No. 150 Hospital
2024
Large Language Models (LLMs) have emerged as a transformative power in enhancing natural language comprehension, representing significant stride toward artificial general intelligence. The application of LLMs extends beyond conventional linguistic boundaries, encompassing specialized systems developed within various scientific disciplines. This growing interest has led to the advent LLMs, novel subclass specifically engineered for facilitating discovery. As burgeoning area community AI...
3001 Background: BL-B01D1 is a first-in-class novel ADC consisting of an EGFRxHER3 bispecific antibody linked to TOP-I inhibitor payload via cleavable linker. We now present safety/efficacy results from FIH phase I study BL-B01D1. Methods: This included patients (pts) with locally advanced or metastatic solid tumors. For dose escalation (D-ESC, i3+3), was administered intravenously at doses 0.27, 1.5, 3.0 mg/kg QW, 2.5, 3.0, 3.5mg/kg D1D8 Q3W 4.5, 5.0, 6.0 D1 Q3W. A subset pts were enrolled...
Abstract The combination of programmed cell death protein 1 (PD-1) and cytotoxic T lymphocyte antigen 4 (CTLA-4) antibodies has potential for enhancing clinical efficacy. We described the development antitumor activity Z15-0, a bispecific nanobody targeting both PD-1 CTLA-4 pathways simultaneously. designed optimized mRNA sequence encoding referred to as Z15-0-2 through series in vitro vivo experiments, we established that significantly increased expression nanobody. Administration...
Non-small cell lung cancer (NSCLC) is the most common type of cancer. Tumor treating fields (TTFields) combined with anti-PD immunotherapy offers a promising strategy to address this issue. Nevertheless, mechanism action (MOA) TTFields therapy in NSCLC has not been thoroughly investigated. This study aims elucidate MOA from aspect improving tumor immune microenvironment (TIME). Using mouse model NSCLC, we tested efficacy anti-PD-1 and anti-PD-L1 immunotherapy. By RNA-seq, differential genes...
Gynecological cancer will become a more important public health problem in future years but limited evidence on gynecological burden China.
Primary graft dysfunction (PGD) is a severe form of acute lung injury resulting from ischemia/reperfusion (I/R) in transplantation (LTx), associated with elevated post-transplant morbidity and mortality rates. Neutrophils infiltrating during reperfusion are identified as pivotal contributors to I/R by releasing excessive neutrophil extracellular traps (NETs) via NETosis. While alveolar macrophages (AMs) involved regulating chemotaxis infiltration, their role NETosis remains inadequately...
Abstract Background Epileptic encephalopathy is a devastating epilepsy with etiologies largely elusive, despite whole-gene/exon sequencing of large cohorts. This study targeted the genetic causes childhood epileptic encephalopathy, typically Lennox-Gastaut syndrome (LGS) featured by age-dependent onset and characteristic clinical manifestations. Methods Trio-based whole-exome was performed in 235 LGS cases individualized analyses on each trio explainable inheritance origin stratified...
Abstract Background The emergence and spread of artemisinin resistance threaten global malaria control elimination goals, encourage research on the mechanisms drug in parasites. Mutations Plasmodium falciparum Kelch 13 ( Pf K13) protein are associated with resistance, but unique or common mechanism which results this is unclear. Methods We analyzed effects K13 mutation transcriptome proteome P. at different developmental stages. Additionally, number merozoites, hemozoin amount, growth 3D7...
Knowledge sharing (KS) and team creativity are crucial to achieving complex goals in a construction project. However, the information age, there is lack of research on exploring influencing mechanisms among two dimensions technology (IT) innovations (i.e., intra- interorganizational IT innovations) types KS tacit explicit KS), along with projects. Therefore, this paper builds theoretical model relationships aforementioned variables. To validate feasibility model, 289 valid questionnaires...
Background Gallbladder cancer (GBC) is a fatal cancer, and the efficacy of current standard second-line chemotherapy for GBC limited. Novel therapies need to be explored. This retrospective analysis was aimed investigate outcomes patients treated at West China Hospital with PD-1 inhibitors combined nab-paclitaxel-based (nab-paclitaxel monotherapy or nab-paclitaxel plus other cytotoxic agents) in setting. Methods Between April 2020 May 2022, advanced receiving after resistance first-line...
To explore the relationship between autistic clinical profiles and age at first concern diagnosis among children with autism spectrum disorder. The included severity of autism, cognition, adaptability, language development, regression.The multivariate linear regression model was used to examine association diagnostic first-concern further stratification analysis.A total 801 were included. Language delay associated earlier (language delay: crudeβ: -0.80, 95%CI%: -0.92--0.68; regression:...
Abstract Background/Purpose: Chimeric antigen receptor (CAR) T cell therapy has shown remarkable responses in hematologic malignancies. However, suboptimal clinical outcomes have been associated with decreased expansion and persistence of adoptive transferred CAR-T cells, antigen-negative relapses, impairment by an immunosuppressive tumor microenvironment. We previously developed CD19CAR-T cells secreting PD-1Ab21 fusion protein composed anti-PD-1 single chain antibody...
Abstract Background: BL-M07D1 is an anti-HER2 antibody-drug conjugate (ADC) comprised of a humanized antibody, cathepsin B cleavable linker, and novel topoisomerase I inhibitor (Ed-04). Methods: This study included subjects with locally advanced or metastatic HER2 expressing (positive/low) breast cancer (BC) other solid tumors. would be administered at doses 1.0mg/kg Day 1 & 8 every 3 weeks (D1D8 Q3W) 2.6, 3.2, 3.8, 4.4, 5.0, 5.6, 6.2, 6.8 7.4 mg/kg (D1Q3W) during dose escalation...
Objective: Conducted a systematic meta-analysis on the changes in follow-up parameters of echocardiography patients with primary aldosteronism after surgery and drug treatment, order to explore their differences. Design method: We conducted PubMed, Embase, Cochrane library databases for English full-text articles study PA before treatment published from its establishment until June 1, 2023,Perform included studies using RevMan software. Results: A total 515 (>18 years old) were 4 studies,...
Functional changes in subcutaneous adipose tissue (SAT) occur earlier the aging process and play an important role occurrence development of age-related metabolic diseases. The mechanism this phenomenon is still unclear, change with age poorly understood. We used transcriptome sequencing (RNA seq) to screen differentially expressed genes at mRNA level, analyzed functional characteristics differential through GO KEGG analysis human SAT all ages. In order clarify specific change, we chromatin...
Abstract The emergence and development of artemisinin resistance threaten global malaria control elimination goals, thereby prompting research on the mechanisms parasite resistance. mutation Plasmodium falciparum Kelch 13 ( PfK13) protein is associated with resistance, but unique or common mechanism by which it leads to this unclear. By analyzing different effects PfK13 P. transcriptome proteome at stages, we found that did not significantly change glycolysis, TCA, pentose phosphate pathway...