A5033469273- CAR-T cell therapy research
- Monoclonal and Polyclonal Antibodies Research
- interferon and immune responses
- Protein Tyrosine Phosphatases
- Cancer-related molecular mechanisms research
- Immunotherapy and Immune Responses
- Cholinesterase and Neurodegenerative Diseases
- Apelin-related biomedical research
- Biosimilars and Bioanalytical Methods
- Pharmacological Effects of Natural Compounds
- Axon Guidance and Neuronal Signaling
- Computational Drug Discovery Methods
- Cancer Mechanisms and Therapy
- Glycosylation and Glycoproteins Research
- Asthma and respiratory diseases
- Protein purification and stability
- Cancer Immunotherapy and Biomarkers
- Immune Cell Function and Interaction
Shanghai Cell Therapy Research Institute
2024
Southwest Medical University
2022-2024
First Affiliated Hospital of Hunan University of Traditional Chinese Medicine
2024
Abstract The combination of programmed cell death protein 1 (PD-1) and cytotoxic T lymphocyte antigen 4 (CTLA-4) antibodies has potential for enhancing clinical efficacy. We described the development antitumor activity Z15-0, a bispecific nanobody targeting both PD-1 CTLA-4 pathways simultaneously. designed optimized mRNA sequence encoding referred to as Z15-0-2 through series in vitro vivo experiments, we established that significantly increased expression nanobody. Administration...
Abstract Background: The conversion of suitable antibodies into functional CAR-T therapy presents challenges. Traditional methods for antibody discovery and screening face significant bottlenecks, including the difficulty high-throughput identification high-quality with diverse epitope affinity coverage, also carry a high risk missing functionally relevant candidates or falsely identify unsuitable candidates. Methods: Here, we introduce CARP (CAR-T AI-powered Rapid Platform), novel solution...
Introduction VHHs (VH of heavy-chain-only antibodies) represent a unique alternative to Q7 conventional antibodies because their smaller size, comparable binding affinity and biophysical properties. Method In this study, we systematically analyzed VHH NGS sequences from 22 Alpacas structure data public database. Results in Alpaca can be grouped into five main types with multiple distinct sequence features. Based on the existence hallmark residues FR2 region, classified two groups:...
To explore the molecular mechanism of Sijunzi Decoction (SJZD) in treatment Parkinson's disease (PD) through application network pharmacology, docking, and dynamics simulations, complemented by experimental verification.
Th2-low asthma is mostly steroid-resistant severe asthma, and its specific pathogenesis has not yet been fully elucidated. We found that IL-6 IL-8 were highly expressed in the sputum supernatant of ephrin type-A receptor 2 (EphA2) was on bronchial epithelial cells. So, there a connection between these two phenomena? To clarify this question, we stimulated cells 16HBE with Dermatophagoides pteronyssinus compontents LPS, respectively, detected activation EphA2, downstream pathways, secretion...