A5055418859- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Liver Disease and Transplantation
- Monoclonal and Polyclonal Antibodies Research
- Cancer Immunotherapy and Biomarkers
- CAR-T cell therapy research
- Organ Transplantation Techniques and Outcomes
- Hepatitis B Virus Studies
Shanghai Cell Therapy Research Institute
2024
Fujian Medical University
2011
Abstract The combination of programmed cell death protein 1 (PD-1) and cytotoxic T lymphocyte antigen 4 (CTLA-4) antibodies has potential for enhancing clinical efficacy. We described the development antitumor activity Z15-0, a bispecific nanobody targeting both PD-1 CTLA-4 pathways simultaneously. designed optimized mRNA sequence encoding referred to as Z15-0-2 through series in vitro vivo experiments, we established that significantly increased expression nanobody. Administration...
<i>Background:</i> This study aims to establish a stable chronic rejection model for orthotopic liver transplantation in the rat and describe pathological features of this model. <i>Methods:</i> The livers from different strains rats were transplanted various allogeneic donor-recipient combinations with appropriate syngeneic grafts used as controls. untreated after surgery (acute model) or treated cyclosporin A (1 mg/kg) hydrocortisone (0.75 determined by activity...
Previous study has identified that the genetic variants in human leukocyte antigen (HLA)-DP/DQ region were strongly associated with hepatitis B virus (HBV) infection. But their roles liver function recovery after hepatic transplantation still obscure. This aimed to investigate whether HLA-DP/DQ polymorphisms post-transplant etiologies and prognosis Chinese transplant recipients. A total of 144 recipients enrolled, which divided into 2 groups according etiology: HBV-related disease...