A5006660603- Cholangiocarcinoma and Gallbladder Cancer Studies
- Peptidase Inhibition and Analysis
- Colorectal and Anal Carcinomas
- Colorectal Cancer Treatments and Studies
- Pancreatic and Hepatic Oncology Research
- Gastric Cancer Management and Outcomes
- Cancer Mechanisms and Therapy
- Colorectal Cancer Surgical Treatments
- Gallbladder and Bile Duct Disorders
- Esophageal Cancer Research and Treatment
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- CAR-T cell therapy research
- Colorectal Cancer Screening and Detection
- Genetic factors in colorectal cancer
- Cancer Immunotherapy and Biomarkers
- Genital Health and Disease
- Hepatocellular Carcinoma Treatment and Prognosis
- Gastrointestinal Tumor Research and Treatment
- Protease and Inhibitor Mechanisms
- Cancer Genomics and Diagnostics
- Viral-associated cancers and disorders
- Cytokine Signaling Pathways and Interactions
- Angiogenesis and VEGF in Cancer
- Lung Cancer Research Studies
Nanjing Medical University
2025
Sichuan University
2016-2025
Sichuan Cancer Hospital
2022-2025
State Key Laboratory of Biotherapy
2014-2024
West China Hospital of Sichuan University
2020-2024
National Cancer Center
2024
West China Medical Center of Sichuan University
2016-2022
Hypoxia-inducible factor 1 alpha (HIF-1alpha) and vascular endothelial growth (VEGF) are frequently overexpressed in numerous types of cancers known to be important regulators angiogenesis. Until now, few studies have been carried out investigate the prognostic role these factors solid tumors, especially colorectal cancer (CRC). The purpose this study was evaluate expression HIF-1alpha VEGF CRC tissues, analyze association two with several clinical pathological characteristics, patients'...
Chimeric antigen receptor-modified T cells (CAR-T cells) have emerged as a promising cancer immunotherapy for solid tumors. Epithelial cell adhesion molecule (EpCAM) is overexpressed in variety of tumors and recognized biomarker circulating tumor stem cells, representing an attractive target adoptive T-cell immunotherapy. This study generated third-generation CAR-T with redirected specificity to EpCAM (EpCAM CAR-T) by lentiviral vector. The demonstrated that can elicit lytic cytotoxicity...
Cyclooxygenase-2 (COX-2) has recently been considered to promote lymphangiogenesis by up-regulating vascular endothelial growth factor-C (VEGF-C) in breast and lung cancer. However, the impact of COX-2 on gastric cancer remains unclear. This study aims test expression VEGF-C human cancer, analyze correlation with lymphatic vessel density (LVD), clinicopathologic features survival prognosis.Using immunohistochemistry, COX-2, level LVD were analyzed 56 R0-resected primary adenocarcinomas,...
Abstract Colorectal carcinoma (CRC) is the one of most common cancers with considerable metastatic potential, explaining need for new drug candidates that inhibit tumor metastasis. The signal transducers and activators transcription 3 (Stat3) signaling pathway has an important role in CRC been validated as a promising anticancer target therapy. In present study, we report our findings on nifuroxazide, antidiarrheal agent identified inhibitor Stat3. Our studies showed nifuroxazide decreased...
Enhancing the anti-colon cancer activity of quercetin by self-assembled micelles Guangya Xu,1,* Huashan Shi,2,* Laibin Ren,1 Hongfeng Gou,1 Daoyin Gong,1 Xiang Gao,1–3 Ning Huang11Department Pathophysiology, West China College Preclinical Medicine and Forensic Medicine, Sichuan University, Chengdu, Sichuan, People’s Republic China; 2State Key Laboratory Biotherapy Cancer Center, 3Department Neurosurgery, Hospital, Medical School, China*These authors contributed equally to this workAbstract:...
To evaluate the added value of additional 68Ga-FAPI PET/CT following CT for primary staging, detection postoperative recurrence, and management gastric cancer patients. We retrospectively included patients with cancers who underwent contrast-enhanced computed tomography (ceCT), followed by within 30 days. was performed initial staging or recurrence. Two nuclear medicine physicians a radiologist independently decided on imaging-based staging. Pre-68Ga-FAPI treatment decisions were made...
Abstract Background This study aims to explore the genetic characteristics of biliary tract cancer (BTC), with a particular focus on impact DNA damage response and repair (DDR) genes clinical outcomes. Methods A total 180 patients BTC next‐generation sequencing data were retrospectively analyzed. Clinical outcomes compared between DDR‐positive DDR‐negative groups. Results DDR mutations found in 28.3% patients, ATM (7.8%), BAP1 (5.6%), BRCA2 (3.3%) being most common. receiving first‐line...
Gastric cancer (GC) is one of the most prevalent malignant tumors worldwide, often diagnosed at an advanced stage with a poor prognosis. Paclitaxel, nab-paclitaxel, and irinotecan, either as monotherapies or in combination ramucirumab, are currently standard second-line treatments for GC. However, efficacy these therapies limited, necessitating development new strategies to improve response rates. Immune checkpoint inhibitors (ICIs) have shown success first-line treatment GC, leading...
Periodontitis has recently been recognized as an inflammatory disease caused by oxidative stress, with mitochondrial dysfunction being a key factor leading to stress. PTEN-induced kinase 1 (PINK1) is essential protein for quality control, which protects cells from stress inducing mitophagy degrade damaged mitochondria, but its role in periodontitis not elucidated. This study aimed explore the contribution and underlying mechanisms of Pink1 regulating differentiation function osteoclasts...
Combination of immunotherapy and chemotherapy has shown promise for cancer. Interleukin-7 (IL-7) can potentially enhance immune responses against tumor, while oxaliplatin (OXP), a platinum-based drug, promote favorable microenvironment stimulate anticancer responses. We evaluated the anti-tumor activity IL-7 combining OXP murine colon carcinoma in vitro vivo studied tumor to investigate whether combined treatment affects on local cell populations. Utilizing lung abdomen metastasis models by...
Abstract Chimeric antigen receptor (CAR) T cells have limited efficacy against solid tumors due to the hostile microenvironment. Circulating tumor (CTCs) are essential metastasis, which is cause of most cancer-related death. Here, we generated GrB-CAR targeting membrane-bound HSP70 (mHSP70), a highly tumor-specific detected in numerous cancers. exhibited potent cytotoxicity broad spectrum cancer cell lines and stem-like vitro effectively inhibited xenograft growth vivo . Importantly,...
Immune checkpoint inhibitors (ICIs) have demonstrated promising outcomes in small cell lung cancer (SCLC), but not all patients benefit from it. Thus, developing precise treatments for SCLC is a particularly urgent need. In our study, we constructed novel phenotype based on immune signatures.We clustered with hierarchically 3 publicly available datasets according to the signatures. ESTIMATE and CIBERSORT algorithm were used evaluate components of tumor microenvironment. Moreover, identified...
This study describes the epidemiological and microbiological profile of sepsis during first decade 21(st) century in mainland China.The sepsis-related mortality data from 2003 2007 were retrieved China Health Statistical Yearbook. The microbiology selected a literature search Academic Journal Database between 2001 2009. A meta-analysis was performed to synthesize available on proportion positive blood cultures septic patients microorganism distribution.The small medium-sized cities rural...
Abstract Biliary tract cancer (BTC) is a highly aggressive malignancy with limited second‐line therapy. We conducted this phase 2 trial to evaluate the efficacy and safety of nab‐paclitaxel plus sintilimab in advanced BTC. Histologically confirmed BTC patients documented disease progression after first‐line chemotherapy were enrolled. Subjects received 125 mg/m on days 1 8 200 mg day 1, administered every 3 weeks. The primary end point was objective response rate (ORR). secondary points...
Accurate baseline clinical staging is critical to inform treatment decision-making for patients with gastric cancers. Peritoneal metastasis (PM) the most common form of in cancer and mainly diagnosed by diagnostic laparoscopy peritoneal lavage evaluation. However, invasive less cost-effective. It urgent develop a safe, fast non-invasive functional imaging method verify cancer. The aim our study was evaluate proportion whom 68Ga-FAPI-04 positron emission tomography/CT (PET/CT) led change...
Interleukin-18 (IL-18) has been demonstrated to augment the antitumor capacity of chimeric antigen receptor-T cells (CAR-T) but underlying mechanisms are largely unknown. Here we explored effects and exogenous IL-18 on response CAR-T cells. boosted cytotoxicity human epidermal growth factor receptor-2 (HER2)-specific ex vivo enhanced efficacy in immunodeficient mice, moreover, improved OVA-specific T immunocompetent indicating universal enhancing function for adoptive cell therapy. To...