A5101857337- Cancer Immunotherapy and Biomarkers
- Peptidase Inhibition and Analysis
- Lung Cancer Research Studies
- RNA Interference and Gene Delivery
- CAR-T cell therapy research
- Immunotherapy and Immune Responses
- Neuroendocrine Tumor Research Advances
- Genomics, phytochemicals, and oxidative stress
- Circular RNAs in diseases
- Pancreatic and Hepatic Oncology Research
- Cancer-related molecular mechanisms research
- Plant-based Medicinal Research
- Nanoplatforms for cancer theranostics
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Intraperitoneal and Appendiceal Malignancies
- Adipokines, Inflammation, and Metabolic Diseases
- Signaling Pathways in Disease
- Lung Cancer Treatments and Mutations
- Cancer Mechanisms and Therapy
- Lung Cancer Diagnosis and Treatment
- Hedgehog Signaling Pathway Studies
- Gastrointestinal Tumor Research and Treatment
- Gastric Cancer Management and Outcomes
- Viral-associated cancers and disorders
- Allergic Rhinitis and Sensitization
Sichuan Cancer Hospital
2024
Sichuan University
2019-2024
West China Medical Center of Sichuan University
2023
Weatherford College
2021
Hangzhou Dianzi University
2017
Oral diseases include oral cancer, periodontitis, endodontium infection, and caries. The cavity is prone to the proliferation of pathogenic bacteria infectious owing its unique environment. During drug-based treatment diseases, saliva can dilute drug formulation, reduce interaction between site action, weaken efficacy. Therefore, searching an effective delivery approach extremely critical urgent. Stimuli responsive hydrogels respond altered environmental conditions under disease states,...
Background: Cytokine storm (CS) is a systemic inflammatory syndrome and major cause of multi-organ failure even death in COVID-19 patients. With the increasing number patients, there an urgent need to develop effective therapeutic strategies for CS. Baicalin anti-inflammatory antiviral traditional Chinese medicine. In present study, we aimed evaluate mechanism baicalin against CS through network analysis experimental validation, detect key targets that may bind closely molecular docking....
Abstract Breast cancer has become the most common and greatest threat to women's health in world. As dangerous subtype of breast cancer, triple‐negative (TNBC) can lead develop drug resistance, resulting poor therapeutic effects. The synergistic effect radiotherapy immunotherapy not only improve situ TNBC but also induce strong abscopal remove tumor cells from metastatic prevent recurrence. However, many preclinical studies have pointed out that application radioimmunotherapy still such...
Immune checkpoint inhibitors (ICIs) have demonstrated promising outcomes in small cell lung cancer (SCLC), but not all patients benefit from it. Thus, developing precise treatments for SCLC is a particularly urgent need. In our study, we constructed novel phenotype based on immune signatures.We clustered with hierarchically 3 publicly available datasets according to the signatures. ESTIMATE and CIBERSORT algorithm were used evaluate components of tumor microenvironment. Moreover, identified...
An in situ spontaneously forming micelle-hydrogel system was developed for localized sequential chemotherapy; it released drugs programmatically and exerted remarkable anti-tumor efficacy.
Gastric mixed neuroendocrine-non-neuroendocrine tumor (MiNEN), a rare malignancy, currently has no standard treatment. Here, we report patient with pathologically confirmed gastric MiNEN following radical surgery rapid postoperative distant recurrence. Immunofluorescence results suggested intensive lymphocyte infiltration in the tumor. The programmed death receptor ligand 1 (PD-L1) immunohistochemistry 22C3 pharmDx assay showed proportion score was 5% and combined positive 10. After 6 cycles...
Immune checkpoint blockade (ICB) therapy has revolutionized the treatment of various types cancer. However, even promising systemically administered ICB agents can cause immune-related adverse events (irAEs). The management irAEs been a significant concern. In addition to risk compromised immune function with corticosteroids and other immunomodulatory regimens used treat irAEs, complex mechanisms make "off-target" effects extremely challenging. Various materials high biocompatibility,...
Objectives Small cell lung carcinoma (SCLC) is a highly malignant tumor characterized by early metastasis even at the time of diagnosis. Although pancreatic occurring in SCLC common observation literatures, there currently very limited experience with metastasis-induced acute pancreatitis patients. Methods Here we retrospectively analyzed patients and West China Hospital between 2009 2017. The were diagnosed as having bronchoscopic biopsy or computed tomography–guided percutaneous biopsy....
According to the biological function of fatigue resistance possessed by biology, this study designed a Bionic Coupling Brake Disc (BCBD) which can inhibit crack propagation as result improving property. Thermal stress field brake disc was calculated under emergency working condition, and circumferential radial lead failure were investigated simultaneously. Results showed that maximum temperature surface reached 890°C residual tensile 207 Mpa when initial velocity vehicle 200 km/h. Based on...
Abstract Rationale: Lung cancer and pulmonary infections can have similar clinical radiographic manifestations. Treatment for the coexistence of epidermal growth factor receptor (EGFR)-mutant adenocarcinoma tuberculosis remains unclear. Patient concerns: We reported a case EGFR- mutant lung (mimicking infections) that coexisted with during course disease. Diagnoses: The patient was initially diagnosed pneumonia-like EGFR exon 19 deletions based on computed tomography scan, fiberoptic...