A5067514985- Nanoparticle-Based Drug Delivery
- Intracranial Aneurysms: Treatment and Complications
- Meningioma and schwannoma management
- Glioma Diagnosis and Treatment
- RNA Interference and Gene Delivery
- Traumatic Brain Injury and Neurovascular Disturbances
- Immunotherapy and Immune Responses
- Neurosurgical Procedures and Complications
- Pituitary Gland Disorders and Treatments
- Synthesis of Organic Compounds
- Cerebrovascular and Carotid Artery Diseases
- Natural Compound Pharmacology Studies
- Curcumin's Biomedical Applications
- Cerebrospinal fluid and hydrocephalus
- Fetal and Pediatric Neurological Disorders
- Vascular Malformations Diagnosis and Treatment
- Neurological Complications and Syndromes
- Synthesis of Indole Derivatives
- Educational Technology and Pedagogy
- Protein Degradation and Inhibitors
- Ubiquitin and proteasome pathways
- Nanoplatforms for cancer theranostics
- Immune Cell Function and Interaction
- CAR-T cell therapy research
- Clusterin in disease pathology
Sichuan University
2016-2025
West China Hospital of Sichuan University
2012-2025
State Key Laboratory of Biotherapy
2016-2024
West China Medical Center of Sichuan University
2020
Chengdu University
2016
Yale University
2016
Howard Hughes Medical Institute
2013
National Institutes of Health
2013
Wellcome Trust
2013
Southwest Jiaotong University
2001-2002
Curcumin (Cur) is a natural extract of Asian spice longa, showing multi-targeting capability and low toxicity in anti-tumor activities. The bioavailability restricts its application as therapeutic agent. Folate (FA) receptors are highly expressed many malignant tumors while normal tissue. Herein, we developed self-assembled FA modified MPEG-PCL micelle to incorporate Cur (FA/Nano-Cur) applied it for colorectal cancer therapy.We prepared FA/Nano-Cur micelles identified their characteristics....
Ovarian cancer is a stubborn malignancy of gynecological system with high mortality rate. Docetaxel (DTX), the second-generation anti-tumor drug Taxane, has shown superior efficacy over classic paclitaxel (PTX) in certain cancers. However, its clinical application hindered by poor bioavailability. The natural spice extract curcumin (Cur) been discovered to improve bioavailability DTX. Therefore, it meaningful develop combined strategy DTX and Cur methoxy poly (ethylene glycol)-poly (L-lactic...
Biodegradable micelles enhance the antiglioma activity of curcumin in vitro and vivo Songping Zheng,1,* Xiang Gao,1,2,* Xiaoxiao Liu,1 Ting Yu,1 Tianying Zheng,1 Yi Wang,1 Chao You1 1Department Neurosurgery, West China Hospital, Medical School, Sichuan University, Chengdu, People's Republic China; 2Department Pharmacology, Yale School Medicine, New Haven, CT, USA *These authors contributed equally to this work Abstract: Curcumin (Cur), a natural polyphenol Curcuma longa, has been recently...
Hepatocellular carcinoma (HCC) is one of the most lethal human cancers worldwide. The dietary xanthone α-mangostin (α-MGT) exhibits potent anti-tumor effects in vitro and vivo. However, anti-HCC α-MGT their underlying mechanisms are still vague. Aberrant activation signal transducer activator transcription 3 (STAT3) involved progression HCC. We therefore investigated whether inhibited STAT3 thereby its effects. In this study, we found that significantly suppressed cell proliferation, induced...
Immunosuppression tumor microenvironment (TME) seriously impedes anti-tumor immune response, resulting in poor immunotherapy effect of cancer. This study develops a folate-modified delivery system to transport the plasmids encoding stimulatory chemokine CKb11 and PD-L1 inhibitors cells, high secretion from successfully activating cells increasing cytokine reshape TME, ultimately delaying progression. The enhances effectiveness by infiltration TME. It can cause expression IFN-γ, which is...
// Songping Zheng 1, * , Yongzhong Cheng Yan Teng 1 Xiaoxiao Liu Ting Yu Yi Wang Jiagang Yuzhu Hu Cong Wu Xiang Yanhui Chao You Gao and Yuquan Wei Department of Neurosurgery Institute Neurosurgery, State Key Laboratory Biotherapy, West China Hospital, Medical School, Sichuan University Collaborative Innovation Center for Chengdu, 610041, PR These authors have contributed equally to this work Correspondence to: Gao, email: xiangxianggao2008@163.com Keywords: luteolin, glioma, chemotherapy,...
Luteolin (Lut) is a natural flavonoid mainly extracted from vegetables and fruits. Lut shows great anti-tumor potential in many malignant cancers, which are hindered by poor water solubility low bioavailability. Peritoneal metastasis challenge for colorectal cancer treatment, usually indicating unfavorable prognosis of patients. Methoxy poly(ethylene glycol)-poly( ε -caprolactone) micelles containing (Lut-M) thermosensitive Pluronic ® F127 coated Lut-M (Lut-M-F127) were synthesized applied...
Drug resistance has become an obstacle to successful cancer chemotherapies, with therapeutic agents effectively traversing the blood-brain barrier (BBB) remaining a great challenge. A microenvironment responsive and active targeting nanoparticle was constructed enhance penetration of drugs, leading improved effects. Dynamic light scattering demonstrated that prepared had uniform size. The cRGD modification renders capabilities traverse BBB for chemotherapy. disulfide-bond-containing can be...
Pituitary adenomas and intracranial aneurysms are prevalent neurosurgical conditions, but their simultaneous presence is uncommon, affecting only 0.5%-7.4% of those with pituitary adenomas. The strategy treating endovascularly before removing widely adopted, yet reports on addressing both conditions at once through an endoscopic endonasal approach (EEA) scarce. We present a case involving adenoma coupled anterior communicating artery aneurysm. Utilizing the EEA, we excised clipped aneurysm...
Alpha-mangostin (α-MG), one of the key xanthone derivatives, displays a multiplicity curative qualities like antiinfective, anti-malarial, anticarcinogenic, antidiabetic actions as well antioxidant properties. Furthermore, it has proven to have neuroprotective, hepatoprotective, and cardioprotective features, which anticarcinogenic action is most auspicious. Additionally, several in vitro vivo analyses confirm that α-MG partakes major stages tumor growth: initiation, promotion, progression....
Hon/MPEG-PCL nanoparticles were parpered by self-assembly method and showed therapeutic potential in the treatment of osteosarcoma.
Mangostin is a hydrophobic agent with potential anticancer activity. Molecular dynamics computer simulation indicated methoxy poly(ethylene glycol)-poly(lactide) (MPEG-PLA) and α-mangostin (α-M) have good compatibility. The α-M-loaded nano-particles acting as an agents against growth of glioma cells were prepared by self-assembly methods. In this study, the effects nano-particles, α-M/MPEG-PLA drug loading 15% mean particle size 32 nm, on examined both in vitro vivo. occurrence changes cell...
Objective: It is relatively rare that chronic subdural hematoma (CSDH) occurs in young people. The aim of this study was to investigate how often an arachnoid cyst (AC) associated with CSDH patients by collecting and analyzing cases In addition, we would discuss the association between AC CSDH, which supposed help diagnosis treatment AC. Methods Materials: This collected 45 consecutive patient head injury our hospital from February 2009 December 2011. Five were diagnosed as performing either...
Bacterial ventriculitis is one of the most difficult diseases neurosurgery, if not controlled well in early stage, it will cause empyema, adhesion and separated infectious ventricle locules inside ventricle.Few studies focus on relationship between external drainage volume occurrence separation ventricle.This paper reported a case ventriculitis, we propose that excessive might increase rate internal patients with ventriculitis.Choosing an appropriate method avoiding be key to treatment ventriculitis.
Parasagittal meningiomas (PM) are very common intracranial lesion but their occurrence in young adult is rare. Most giant PM characterized with the invasion of superior sagittal sinus and form huge collaterals which makes surgical resection difficult. The origin meningioma still a matter debate make our case much more puzzling. We therefore reviewed detailed literature on etiologies as well. present 24-years old lady history seizures, blurred vision, intermittent tremors occasional dropping...