A5108077363- Venomous Animal Envenomation and Studies
- Ion channel regulation and function
- Biochemical and Structural Characterization
- Marine Invertebrate Physiology and Ecology
- Healthcare and Venom Research
- Bauxite Residue and Utilization
- 2D Materials and Applications
- Metallurgy and Material Science
- Erythrocyte Function and Pathophysiology
- Eicosanoids and Hypertension Pharmacology
- Blood Coagulation and Thrombosis Mechanisms
- Crystallization and Solubility Studies
- Cellular transport and secretion
- High Altitude and Hypoxia
- Nanowire Synthesis and Applications
- Plant-based Medicinal Research
- X-ray Diffraction in Crystallography
- Metallurgy and Material Forming
- Rabies epidemiology and control
- Titanium Alloys Microstructure and Properties
- Adipose Tissue and Metabolism
- Calpain Protease Function and Regulation
- Cancer, Hypoxia, and Metabolism
- Plasmonic and Surface Plasmon Research
- Ferroptosis and cancer prognosis
Southeast University
2024-2025
State Key Laboratory of Digital Medical Engineering
2024-2025
General Research Institute for Nonferrous Metals (China)
2022-2024
Grinm Advanced Materials (China)
2022-2024
Zhoukou Normal University
2024
Changchun University of Science and Technology
2024
State Key Laboratory of Nonferrous Metals and Processes
2022-2024
Chongqing University
2023
State Key Laboratory of Biotherapy
2023
Union Hospital
2023
Triple-negative breast cancer (TNBC) is the most aggressive subtype with limited effective therapies because of absence definitive targets. Here, we demonstrate that expression ZNF451, a poorly characterized vertebrate zinc-finger protein, upregulated in TNBC and associated poor prognosis. Elevated ZNF451 facilitates progression by interacting enhancing activity transcriptional activator snail family repressor 2 (SLUG). Mechanistically, ZNF451-SLUG complex preferentially recruits...
Abstract Through strategic engineering of component composition and energy band alignment, 1D core–shell nanostructures can be precisely designed as suitable radial heterostructures to confine the optical field regulate carrier transport. These structures synergistically integrate extend functionalities individual materials or devices. By integrating a p ‐type narrow‐band Se material with an n ‐ZnO core, ZnO/Se heterojunction is fabricated for self‐powered broadband photodetector (PD). This...
To study the effect of aluminum and nickel elements on microstructures properties nickel-aluminum bronze (NAB) alloy, four kinds alloys with different compositions, ZCuAl7-7-4-2, ZCuAl8-6-4-2, ZCuAl9-5-4-2, ZCuAl10-4-4-2, are prepared by vacuum-melting technology. The effects Al/Ni ratios NAB investigated using a metalloscope, scanning electron microscopy, transmission XPS analysis. mechanical property is evaluated microhardness testing tensile testing. corrosion resistance mass-loss...
An L-amino acid oxidase (LAAO), NA-LAAO, was purified from the venom of Naja atra. Its N-terminal sequence shows great similarity with LAAOs other snake venoms. NA-LAAO dose-dependently induced aggregation washed human platelets. However, it had no activity on platelets in platelet-rich plasma. A low concentration greatly promoted effect hydrogen peroxide, whereas peroxide itself little activation tyrosine phosphorylation a number platelet proteins including Src kinase, spleen and...
Background: Tumor microenvironment (TME) has been reported to have a strong association with tumor progression and therapeutic outcome, epigenetic modifications such as DNA methylation can affect TMB play an indispensable role in tumorigenesis. However, the potential mechanisms of TME remain unclear cervical cancer (CC). Methods: The immune stromal scores were generated by ESTIMATE algorithm for CC patients Cancer Genome Atlas (TCGA) database. methylation-related genes identified integrative...
Drug resistance has become an obstacle to successful cancer chemotherapies, with therapeutic agents effectively traversing the blood-brain barrier (BBB) remaining a great challenge. A microenvironment responsive and active targeting nanoparticle was constructed enhance penetration of drugs, leading improved effects. Dynamic light scattering demonstrated that prepared had uniform size. The cRGD modification renders capabilities traverse BBB for chemotherapy. disulfide-bond-containing can be...