A5013136850- Coal Properties and Utilization
- Combustion and Detonation Processes
- Aerosol Filtration and Electrostatic Precipitation
- Immunotherapy and Immune Responses
- Particle Dynamics in Fluid Flows
- Cancer Immunotherapy and Biomarkers
- Wind and Air Flow Studies
- Cyclone Separators and Fluid Dynamics
- Immune cells in cancer
- Air Quality and Health Impacts
- RNA Interference and Gene Delivery
- Granular flow and fluidized beds
- Vehicle emissions and performance
- Immune Response and Inflammation
- Nanoplatforms for cancer theranostics
- Immune Cell Function and Interaction
- Cancer Research and Treatments
- Cancer, Hypoxia, and Metabolism
- Aerodynamics and Fluid Dynamics Research
- Cancer Mechanisms and Therapy
- Aeolian processes and effects
- Cancer, Lipids, and Metabolism
- Neonatal Respiratory Health Research
- Angiogenesis and VEGF in Cancer
- Nanoparticle-Based Drug Delivery
Shandong University of Science and Technology
2021-2025
State Key Laboratory of Biotherapy
2012-2024
Sichuan University
2013-2024
Guangxi Medical University
2024
Zhejiang University
2021
West China Medical Center of Sichuan University
2015
Immunotherapy has achieved prominent clinical efficacy in combating cancer and recently become a mainstream treatment strategy. However, achieving broad with single modality is challenging, the heterogeneity of tumor microenvironment (TME) restricts accuracy effectiveness immunotherapy strategies for tumors. Herein, TME-responsive targeted nanoparticle to enhance antitumor immunity reverse immune escape by codelivering interleukin-12 (IL-12) expressing gene colony-stimulating factor-1...
Abstract λ-Carrageenan is a seaweed polysaccharide which has been generally used as proinflammatory agent in the basic research, however, how immunomodulating activity of λ-carrageenan affects tumor microenvironment remains unknown. In this study, we found that intratumoral injection could inhibit growth B16-F10 and 4T1 bearing mice enhance immune response by increasing number tumor-infiltrating M1 macrophages, DCs more activated CD4 + CD8 T lymphocytes spleen. addition, secretion IL17A...
To define the diffusion behavior of harmful exhaust substances from diesel vehicles and support safety risk assessments underground coal mines, we performed a multi-species coupling calculation emission trackless rubber-wheel vehicle. A computational fluid dynamics (CFD) model emissions was hence established verified. From perspective analysis, distribution hazardous emitted by vehicle were studied under 4 different conditions; moreover, identified areas characterized levels emissions. When...
Rationale: The adverse health effects of nano-particulate pollutants have attracted much attention in recent years. Carbon nanomaterials are recognized as risk factors for prolonged inflammatory responses and diffuse alveolar injury. Previous research indicated a central role macrophages the pathogenesis particle-related lung disease, but underlying mechanism remains largely unknown. Methods: C57BL/6 mice were intratracheally instilled with carbon black nanoparticles (CBNPs). Cell necrosis...
Cationic nanocarriers are reported to induce cell necrosis, especially in the lungs upon systemic administration. The release of damage-associated molecular patterns, such as mitochondrial DNA from injured may result inflammatory toxicity nanocarrier, which has largely limited its clinical application. Partial blocking surface charge cationic might improve their safety. As hyaluronan (HA) is an anionic polysaccharide that widely used for specific binding CD44 cellular uptake efficiency...