A5101916168- Cancer Immunotherapy and Biomarkers
- Head and Neck Cancer Studies
- Head and Neck Surgical Oncology
- Monoclonal and Polyclonal Antibodies Research
- Cancer-related molecular mechanisms research
- Immune Cell Function and Interaction
- Salivary Gland Tumors Diagnosis and Treatment
- Complement system in diseases
- Immunotherapy and Immune Responses
- Immune cells in cancer
- Single-cell and spatial transcriptomics
- CAR-T cell therapy research
- Coal and Its By-products
- Recycling and utilization of industrial and municipal waste in materials production
- RNA modifications and cancer
- Cancer-related Molecular Pathways
- Inflammatory Biomarkers in Disease Prognosis
- Toxin Mechanisms and Immunotoxins
- Safety and Risk Management
- Cancer Diagnosis and Treatment
- Ear and Head Tumors
- Oil Spill Detection and Mitigation
- Capital Investment and Risk Analysis
- Extracellular vesicles in disease
- NF-κB Signaling Pathways
Eye & ENT Hospital of Fudan University
2020-2024
Fudan University
2020-2024
Anhui Science and Technology University
2024
Anhui University of Science and Technology
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2023
Xinqiao Hospital
2018-2023
Army Medical University
2016-2023
Central South University
2015-2023
Institute of Polymers, Composites and Biomaterials
2020
Donghua University
2020
This paper examines whether the equity market uncertainty (EMU) index contains incremental information for forecasting realized volatility of crude oil futures. We use 5-min high-frequency transaction data WTI futures and develop six heterogeneous autoregressive (HAR) models based on classical HAR-type models. The empirical results suggest that EMU more than economic policy (EPU) More importantly, we argue is a non negligible additional predictive variable can significantly improve 1-day...
Abstract Complement aids in the construction of an immunosuppressive tumor microenvironment. Tumor cell–derived C3 has been previously reported, but whether and how it acts on antitumor immunity remains to be elucidated. Here, we describe a mechanism for suppressing immunity. was activated intracellularly, which results generation C3a. C3a modulated tumor-associated macrophages via C3a-C3aR-PI3Kγ signaling, thereby repressing Deletion cells that had high expression enhanced efficacy...
Anti–PD-1/PD-L1 therapy, either by anti–PD-1 antibody or anti–PD-L1 antibody, has efficacy reinvigorating tumor-infiltrating CD8 + T cells in a subset of patients with cancer, but it unequal effects on heterogeneous cell populations. Hence, the crucial to efficacious PD-1 blockade therapy remains elusive. Here, we found an increase CD200 cytotoxic lymphocytes (CTLs) upon PD-1/PD-L1 blockade, higher proportions positively related favorable clinical outcome anti–PD-1/PD-L1 three independent...
Abstract Background Cancer cells induce the infiltration of various immune that are located or distributed in different sites and play multiple roles, which have recently been proposed to predict clinical outcomes. We therefore studied prognostic significance presence tumour-infiltrating lymphocytes (TILs) ratios between types hypopharyngeal squamous cell carcinoma (HPSCC). Methods retrospectively analysed 132 consecutive patients diagnosed with advanced HPSCC 2013–2017. Tumoural parenchyma...
Background Dysbiosis of the laryngeal microbiota has been demonstrated to development head and neck squamous cell carcinoma (HNSCC), but association Fusobacterium nucleatum ( F. ) with DNA mismatch repair (MMR) microsatellite instability (MSI) not investigated. Methods The abundance , status deficient MMR (dMMR) MSI, MMR‐related gene expression were analyzed in 171 HNSCC tissues, 61 paired para‐tumor 60 vocal cord polyp tissues. molecular mechanism investigated two human lines (Tu 686...
To evaluate prognostic significance of human papillomavirus (HPV) in hypopharyngeal squamous cell carcinoma patients, and to investigate the effect p53 TP53 mutations on prognosis patients.A total 111 patients were enrolled our retrospective study. HPV infection status was detected formalin-fixed paraffin-embedded tissue by real-time multiplex PCR test. expression immunohistochemical staining. exon analyzed amplification Sanger sequencing. status, mutation compared with clinical outcome...
Primary mucoepidermoid carcinomas (MECs) of the sinonasal tract and nasopharynx are rare entities that represent a diagnostic challenge, especially in biopsy samples. Herein, we present case series MECs skull base its mimics to evaluate clinicopathological molecular characteristics order avoid misdiagnosis.
This study is aimed at investigating the expressions and prognostic values of secreted or membrane-located proteins (SMPs) in laryngeal squamous cell carcinoma (LSCC). The correlations between SMPs immune cells' infiltrations were also investigated. expression data normal LSCC samples obtained from TCGA GEO datasets. differentially expressed identified, their analyzed. biological functions worse-survival-related explored. LASSO regression, Cox multivariate analysis, nomogram used to...
Aberrant expression of exosomal miRNAs has emerged as a research hotspot. However, no studies have been conducted on the dysregulation derived from cancer-associated fibroblasts (CAFs) in supraglottic laryngeal squamous cell carcinoma (SLSCC).Cancer-associated and paired normal (NFs) SLSCC patients were cultured, exosomes culture supernatants collected identified. Exosomal miRNA was compared each pair CAFs NFs by next-generation sequencing, selected validated reverse...
AbstractBackground Human papillomavirus (HPV) plays a major etiological role in the increasing number of patients with head and neck squamous cell carcinoma (HNSCC).Objectives This study aimed at exploring relationship between HPV infection prognosis hypopharyngeal (HPSCC).Methods We retrospectively analyzed 108 consecutive diagnosed HPSCC from 2015 to 2018. Real-time fluorescent quantitative PCR P16 immunohistochemistry were used detect tissues carcinoma. The numbers CD8, CD4 Foxp3 cells...
Background It was recently suggested that the upregulation of podoplanin (PDPN) in cancer cells plays a significant role tumor invasion and metastasis it is significantly associated with poor prognosis oral, cutaneous, esophageal squamous cell carcinoma. The aim this study to investigate expression pattern PDPN sinonasal carcinoma (SNSCC) evaluate its as prognostic factor for survival outcome. Patients methods This included 59 subjects SNSCC. We retrospectively collected clinical features...
To investigate the expression and prognostic value of c-Jun in hypopharyngeal squamous cell carcinoma (HPSCC).A retrospective study was performed on a cohort 99 HPSCC patients. The phosphorylated-c-Jun (p-c-Jun) evaluated via immunohistochemistry (IHC) staining. Overall survival (OS) progression-free (PFS) were assessed using Kaplan-Meier method multivariate Cox regression analysis.The high p-c-Jun accounted for 60.61% 16.16%, respectively. High closely associated with cT stage (p = 0.0401),...
Information on HPV-associated sinonasal squamous cell carcinoma (SNSCC) is very limited in China. The aim of this study was to determine the prevalence HPV a large cohort SNSCC patients China.Clinical records and formalin-fixed paraffin-embedded tumor specimens from 30 with associated inverted papilloma (IP-SNSCC) 84 de novo (DN-SNSCC) were retrieved between 2010 2017. status determined for each specimen using combination p16 immunohistochemistry GP5+/6+ PCR.Immunohistochemistry positive two...