A5101817943- Head and Neck Surgical Oncology
- Head and Neck Cancer Studies
- Tracheal and airway disorders
- MicroRNA in disease regulation
- Salivary Gland Tumors Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Oral and Maxillofacial Pathology
- Circular RNAs in diseases
- Nasal Surgery and Airway Studies
- Sinusitis and nasal conditions
- Bone Tumor Diagnosis and Treatments
- RNA Research and Splicing
- Endoplasmic Reticulum Stress and Disease
- Meningioma and schwannoma management
- Inflammatory Biomarkers in Disease Prognosis
- Facial Rejuvenation and Surgery Techniques
- Allergic Rhinitis and Sensitization
- Ear Surgery and Otitis Media
- Otitis Media and Relapsing Polychondritis
- Histiocytic Disorders and Treatments
- Ear and Head Tumors
- Transition Metal Oxide Nanomaterials
- Radiomics and Machine Learning in Medical Imaging
- Galectins and Cancer Biology
- Pediatric health and respiratory diseases
Eye & ENT Hospital of Fudan University
2020-2025
Fudan University
2019-2025
Gansu Provincial Hospital
2023
Chinese Academy of Sciences
2022
Shanghai Children's Hospital
2019
Shanghai Jiao Tong University
2019
ABSTRACT Background Skull base necrosis can cause life‐threatening massive bleeding in patients following radiotherapy and chemotherapy for nasopharyngeal carcinoma. Patients with bilateral internal carotid artery rupture hemorrhage are especially susceptible, which is a major challenge clinicians. Methods A team at the Eye ENT Hospital affiliated Fudan University recently successfully treated patient skull after The experienced was extracranial–intracranial bypass surgery, resection of...
Nasopharyngeal carcinoma (NPC) is a malignant epithelial tumor that develops in the nasopharynx. It has distinct ethnic and geographical distribution, emerging evidence suggests it an ecological disease. Most patients respond well to radiation combined with chemotherapy as primary treatment for NPC. However, some will eventually develop radio resistance chemoresistance, resulting recurrence metastasis, which cause of poor prognosis. The processes underlying chemoresistance NPC are complex...
Objective: The aim of this study was to review demographic data, location, clinical symptoms, therapeutic methods, pathological features and relapse in sinonasal/nasopharyngeal pleomorphic adenoma (PA) carcinoma ex (CXPA). Methods: We conducted a retrospective analysis 17 patients who were referred our hospital during 5-year period from 2013 2018. Results: In series, there 7 males 10 females. tumors originated the nasal septum 4 cases, lateral wall cavity 2 maxillary sinus 1 case,...
Background This study aimed to investigate the demographics, treatment outcomes, and prognostic factors of salvage endoscopic nasopharyngectomy in recurrent nasopharyngeal carcinoma (NPC). Methods We conducted a retrospective analysis 189 patients who underwent for NPC from January 2006 June 2018. The Kaplan–Meier method log-rank test were used assess survival rates. A Cox regression model was multivariate analyses. Results included 132 men 57 women study, with median age 51 (range, 25–85)...
The purpose of the present study was to review recurrence and prognostic factors squamous cell carcinoma (SCC) associated with inverted papilloma (IP). A retrospective chart conducted on 21 patients SCC IP, in nasal cavity paranasal sinuses, between March 2007 2017. All underwent surgical treatment: Surgery prior or following adjuvant therapy performed 17 (81.0%). During a mean follow‑up time 47.4 months (range, 3‑123 months), 9 (42.9%) experienced local recurrence, risk T4 stage invasive...
To investigate the expression characteristics of long non-coding RNA SNHG14 in nasopharyngeal carcinoma (NPC) and its effects on epithelial-mesenchymal transition development nano-coated si-SNHG14 as an anti-tumor agent. The cancerous adjacent non-cancerous tissues was monitored using reverse transcriptionpolymerase chain reaction (RT-PCR). Gain- loss-of-function experiments tested regulation SNHG14, miR- 5590-3p, ZEB1 PD-L1. binding association between above three factors verified...
Salvage endoscopic nasopharyngectomy has better survival prognosis and fewer complications in the management of early stage rNPC, compared to re-irradiation. However, treatment modality advanced recurrent nasopharyngeal carcinoma (rNPC) remains controversial. Thus, purpose this study was investigate demographics, clinical outcomes, prognostic factors associated with salvage rNPC.This conducted a retrospective analysis rNPC patients who underwent surgery betweenm January 2014 December 2019....
Tension pneumocephalus (TP) caused by endoscopic endonasal surgery is a serious complication. We report four cases of TP and review other in the literature, with special attention devoted to symptoms, imaging features, therapeutic approaches.A retrospective chart patients who experienced our institution between 2015 2018 was performed. Additionally, MEDLINE database searched for all case series or reports surgery.Eighteen articles were identified review, including from authors' institution;...
The choice between endoscopic surgery and re-radiotherapy as the main treatment modality in patients with advanced recurrent nasopharyngeal carcinoma (rNPC) remains controversial. Therefore, this study, we compared efficacies of intensity-modulated radiotherapy (IMRT) rNPC.All rNPC (T3 T4) who underwent salvage were enrolled from January 2009 to December 2020. Overall survival (OS) was analyzed using a log-rank analysis. Univariate multivariate analyses OS performed Cox regression model....
SUMMARY OBJECTIVE To investigate the relations of T lymphocytes, cytokines, immunoglobulin E, and nitric oxide with otitis media effusion (OME) in children their clinical significances. METHODS Fifty OME treated our hospital were enrolled study (observation group). healthy selected as control. The percentages CD4+ CD8+ lymphocyte CD4+/CD8+ ratio peripheral blood, levels cytokine (IL)-2, IL-4, IL-6, E (IgE) (NO) blood middle ear (MEE) both groups detected. correlations these indexes analyzed....
Background It was recently suggested that the upregulation of podoplanin (PDPN) in cancer cells plays a significant role tumor invasion and metastasis it is significantly associated with poor prognosis oral, cutaneous, esophageal squamous cell carcinoma. The aim this study to investigate expression pattern PDPN sinonasal carcinoma (SNSCC) evaluate its as prognostic factor for survival outcome. Patients methods This included 59 subjects SNSCC. We retrospectively collected clinical features...
BackgroundOlfactory neuroblastoma (ONB) is a rare malignancy arising in the nasal vault. Endoscopic resection has been reported to improve overall survival (OS). At present, clinicopathological predictors of prognosis ONB remain undefined.MethodsData including demographics, clinical characteristics and follow-up information patients treated with endoscopic surgery were collected. Risk factors on OS rates investigated by LASSO Cox analyses. A nomogram was developed evaluated internal...
Purpose There has been a lack of evidence-based management strategies on the nasal presentations Rosai–Dorfman disease (RDD). We aim to investigate clinical manifestation, treatment, and outcomes in patients with RDD. Methods retrospectively reviewed available medical records diagnosed RDD from 2014 2021 at our department. Results A total 26 were included marked female preponderance (2.25:1). The most common symptom affected sites congestion (31%) cavity (73%), respectively. average times...
Abstract Endoplasmic reticulum (ER) stress has been implicated in the mechanisms underlying fibrotic process dilated cardiomyopathy (DCM) and results disease exacerbation; however, molecular details of this mechanism remain unclear. Through microarray bioinformatic analyses, we explored genetic alterations myocardial fibrosis (MF) identified potential biomarkers related to ER stress. We integrated two public datasets, including 19 DCM 16 control samples, comprehensively analyzed differential...
As a cancer stem cells (CSCs) surface marker, Lgr5 plays an important role in the signal transduction of and is potential biomarker for diagnosis prognosis. However, expression prognostic value recurrent nasopharyngeal carcinoma (rNPC) remains ambiguous.We used RNA sequencing to screen differentially expressed mRNAs eleven specimens rNPC tissues five fresh adjacent normal tissue samples CSC Lgr5, was identified. The level also detected by immunohistochemistry Western blot assay. chi-square...