A5049130586- Liver Disease Diagnosis and Treatment
- Health Promotion and Cardiovascular Prevention
- Cardiovascular Health and Risk Factors
- Healthcare Systems and Reforms
- Obesity, Physical Activity, Diet
- Aortic aneurysm repair treatments
- Nutritional Studies and Diet
- Autophagy in Disease and Therapy
- Cardiac, Anesthesia and Surgical Outcomes
- Viral Infections and Immunology Research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Chronic Disease Management Strategies
- Dispute Resolution and Class Actions
- Hepatitis B Virus Studies
- Cerebrovascular and Carotid Artery Diseases
- Disaster Response and Management
- Blood Pressure and Hypertension Studies
- Tuberculosis Research and Epidemiology
- Safety and Risk Management
- Lipid metabolism and disorders
- Epilepsy research and treatment
- Vascular Procedures and Complications
- Dietary Effects on Health
- Diabetes Management and Education
- Hepatitis C virus research
Southern Medical University
2022-2025
Dunhuang Research Academy
2025
Gansu University of Traditional Chinese Medicine
2025
University Medical Center Groningen
2020-2024
University of Groningen
2020-2024
Shenzhen Nanshan Center for Chronic Disease Control
2020-2024
Shenzhen Center for Disease Control and Prevention
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2014-2024
State Key Laboratory of Food Science and Technology
2024
Jiangnan University
2024
Mononuclear phagocytes are a population of multi-phenotypic cells and have dual roles in brain destruction/reconstruction. The phenotype-specific microglia/macrophages traumatic injury (TBI) are, however, poorly characterized. In the present study, TBI was induced mice by controlled cortical impact (CCI) animals were killed at 1 to 14 days post injury. Real-time polymerase chain reaction (RT–PCR) immunofluorescence staining for M1 M2 markers performed characterize phenotypic changes both...
OBJECTIVE The objectives of the study were to determine whether cell cycle transcription factor, FoxM1, is required for glucose homeostasis and β-cell mass expansion in maternal islets during pregnancy FoxM1 essential placental lactogen (PL)-induced proliferation. RESEARCH DESIGN AND METHODS β-Cell mass, proliferation, assessed virgin, pregnant, postpartum mice with a pancreas-wide Foxm1 deletion (FoxM1Δpanc). Wild-type cultured or without PL examined induction. Transgenic overexpressing...
Type 2 diabetes mellitus is a major health burden disproportionately affecting those with lower educational attainment (EA). We aimed to obtain causal estimates of the association between EA and type quantify mediating effects known modifiable risk factors.We applied two-step, two-sample multivariable Mendelian randomisation (MR) techniques using SNPs as genetic instruments for exposure mediators, thereby minimising bias due confounding reverse causation. leveraged summary data on...
Abstract Aim The 2019 ESC/EASD guidelines categorize cardiovascular disease risk (CVD) in patients with diabetes mellitus (DM). Assessing CVD is necessary to identify individuals at very high of CVD, enabling tailored and precise intervention for this high‐risk population. This study aims evaluate the severity a stratification among type 2 DM (T2DM) across different regions China. Methods We conducted cross‐sectional screening from 1 January 2020 30 December 2022. Disease duration, body mass...
The China National Health Survey (CNHS) is the first nationwide multi-ethnic cross-sectional interview and health examination conducted from 2012 to 2017. survey designed study reference intervals for physiological constants as well determinants of noncommunicable diseases among different ethnic populations in areas, so that data can be used enhance clinical diagnosis strategies promotion. CNHS a stratified, multistage cluster sampling method obtain sample 53 895 people aged 20-80 years 10...
Nonalcoholic fatty liver disease (NAFLD) is the most common form of chronic with manifestation over‐accumulation fat in liver. Increasing evidences indicate that NAFLD may be part caused by malfunction very low density lipoprotein (VLDL) secretion. Hepatocyte nuclear factor 4α (HNF4α), a receptor protein, plays an important role sustain hepatic lipid homeostasis via transcriptional regulation genes involved secretion VLDL, such as apolipoprotein B (ApoB). However, exact functional change...
Introduction: Iron overload induces multi-organic injury. But the mechanism of how iron whole body effect on lifespan was not fully understood. Objectives: In this study, we used C. elegans as a model organism to investigate reduces by disturbing lipid metabolism and inducing oxidative stress. Methods: were exposed different concentrations ferrous ammonium citrate (FAC). The lifespan, mobility related mRNA expression worms examined. RH123, DHE NDA probes test mitochondrial membrane potential...
In this case-control study, the main risk factors for atrophic gastritis (AG) were comprehensively analyzed in a real-world environment to identify potential associated with garlic intake and its effects on AG. Design Upper gastrointestinal endoscopy pathological examination performed as part of gastric cancer screening health check-up program. The detailed characteristics both case group healthy control recorded analyzed. All participants fasted at least 4 h urea breath test13C-UBT) was all...
Abstract Since late 2012, coxsackievirus A6 (CVA6) has gradually become the predominant pathogen responsible for hand-foot-mouth disease (HFMD) in several provinces of China. A total 626 patients diagnosed with HFMD Shanghai, China from January 2012 to September 2013 were enrolled this study. Of these, 292 CVA6 infected cases subjected clinical analyses. Whole-genome sequencing, recombination and phylogenetic analyses also performed. recombinant monophyletic lineage was found during an...
Chronic kidney disease (CKD) has a heritable component. We aimed to quantify familial aggregation of CKD in the general population and assess extent which traits could be explained by genetic environmental factors.Cross-sectional 3-generation family study.Data were collected at entry into Lifelines Cohort Study from sample northern Netherlands, composed predominantly individuals European ancestry.Family history CKD.The primary outcome was CKD, defined as estimated glomerular filtration rate...
Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening clinical syndrome. Central nervous system (CNS) involvement severe complication, which can lead to rapid disease development and higher morality. However, this has not been given enough attention in adult HLH. Therefore, we carried out study analyze the features, laboratory findings, treatment outcomes, other characteristics of HLH with CNS involvement.A retrospective analysis 96 patients combined between June 2003 December 2016...
Background: Research has shown that carotid intima-media thickness (CIMT) could help to predict plaque (CP) progression in patients with mild stenosis. However, the debate continues as value of intima (CIT) monitoring development CP severe This study sought evaluate relationships between CIT and ultrasonic characteristics analyze parameters assessing vulnerability advanced human atherosclerosis.
Sepsis‐induced acute kidney injury (SAKI) is a major complication of disease associated with increased mortality and faster progression. Therefore, the development imaging biomarkers to detect septic AKI great clinical interest. In this study, we aimed characterize endogenous chemical exchange saturation transfer (CEST) MRI contrast in lipopolysaccharide (LPS)‐induced SAKI mouse model investigate use CEST for detecting such injury. We used that was generated by i.p. injection 10 mg/kg LPS....
Objective: The aim of this study was to review demographic data, location, clinical symptoms, therapeutic methods, pathological features and relapse in sinonasal/nasopharyngeal pleomorphic adenoma (PA) carcinoma ex (CXPA). Methods: We conducted a retrospective analysis 17 patients who were referred our hospital during 5-year period from 2013 2018. Results: In series, there 7 males 10 females. tumors originated the nasal septum 4 cases, lateral wall cavity 2 maxillary sinus 1 case,...
Pancreatic cancer (PC) is an aggressive and fatal disease with high incidences of metastasis recurrence. However, there are no effective treatment options for the majority PC patients, especially those locally advanced tumors metastatic diseases. Therefore, it urgently needed to develop safe anti-PC therapeutic agents. We have recently identified a novel marine-derived natural product terphenyllin potent activity. The present study was designed investigate efficacy mechanisms action in...
Abstract Ginsenoside Rg1 (G-Rg1) is a bioactive phytochemical that has been found to be beneficial for the treatment of several diseases including nonalcoholic fatty liver disease (NAFLD). But there lack literature reporting effect G-Rg1 on lipid metabolism balance in NAFLD. We investigated and mechanism vitro. decreased levels TG, TC, MDA, increased activity SOD. Results RT-PCR western blotting showed supplementation with downregulated expression PPAR γ, FABP1, FATP2/5, CD36, SREBP1 c,...
Objective Hypertension has become the leading cause of death worldwide. Data on hypertension management among Shenzhen elderly are sparse. Our study aims to investigate treated and controlled in elderly, identify relevant predictors. Design A cross-sectional study. Setting Communities Shenzhen, Guangdong, China. Participants was conducted. We employed a convenience sampling method select participants; 124 007 participants aged 65 years older were recruited from January December 2018 at local...
Background: In parallel with the rise in obesity and metabolic syndrome (MetS), kidney stones are becoming more common. this study, relationship between MetS components a health screening population was examined.