A5100434558- Autoimmune and Inflammatory Disorders Research
- Immune Cell Function and Interaction
- Parvovirus B19 Infection Studies
- Multiple Myeloma Research and Treatments
- Chronic Lymphocytic Leukemia Research
- Kawasaki Disease and Coronary Complications
- Histiocytic Disorders and Treatments
- Protein Degradation and Inhibitors
- Viral-associated cancers and disorders
- Chronic Myeloid Leukemia Treatments
- Cancer therapeutics and mechanisms
- Liver Disease Diagnosis and Treatment
- Childhood Cancer Survivors' Quality of Life
- Renal and related cancers
- Lymphoma Diagnosis and Treatment
- Family and Disability Support Research
- Blood disorders and treatments
- Platelet Disorders and Treatments
- Healthcare and Venom Research
- Computational Drug Discovery Methods
- Erythrocyte Function and Pathophysiology
- Phagocytosis and Immune Regulation
- Pharmacological Effects of Natural Compounds
- Systemic Lupus Erythematosus Research
- Adolescent and Pediatric Healthcare
Capital Medical University
2009-2022
Beijing Friendship Hospital
2009-2022
Beijing Ditan Hospital
2022
Creative Commons
2021
Second Affiliated Hospital of Zhengzhou University
2019
Summary We performed a multicentre, non‐randomised trial (NCT03533790) to investigate the efficacy of ruxolitinib combined with doxorubicin‐etoposide‐methylprednisolone (Ru‐DEP) regimen as salvage therapy for refractory/relapsed haemophagocytic lymphohistiocytosis (HLH). All patients failing achieve complete or partial response 2 weeks after initial HLH‐94/HLH‐04 relapsed remission were enrolled in study between June 2018 and 2019. The was evaluated initiating Ru‐DEP therapy. Fifty‐four...
Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening clinical syndrome. Central nervous system (CNS) involvement severe complication, which can lead to rapid disease development and higher morality. However, this has not been given enough attention in adult HLH. Therefore, we carried out study analyze the features, laboratory findings, treatment outcomes, other characteristics of HLH with CNS involvement.A retrospective analysis 96 patients combined between June 2003 December 2016...
Objectives To describe the clinical characteristics and outcomes of adult macrophage activation syndrome (MAS) patients to provide experience for treatment. Methods Adult with MAS admitted Beijing Friendship Hospital from December 2014 September 2021 were enrolled in this study. Clinical data collected analyzed. Results A total 118 entered was first manifestation 43 (36.4%) patients, while 75 (63.6%) developed after diagnosis autoimmune disease (AID) a median diagnostic interval 2 (0.5–359)...
We reported a case of 19-year-old male patient with central nervous system symptoms as the main clinical manifestations, and multiple intracranial abdominal occupying lesions visualized by imaging examinations, who was initially misdiagnosed NK/T-cell lymphoma but poorly responsive to treatment. Finally, he diagnosed familial hemophagocytic lymphohistiocytosis type-2 genome sequencing, perforin test pedigree study. The survived well after allogeneic hematopoietic stem cell transplantation....
Objective. This study aims to compare the electrocardiogram (ECG) abnormalities and QT interval prolongation in 2,886 patients with viral hepatitis cirrhosis 643 alcoholic order understand characteristics of ECG provide information evidence for clinical diagnosis treatment. Methods. The data liver outpatients inpatients our hospital from August 2012 July 2018 were reviewed. recorded, report was issued by experts analyze abnormal these two groups. Results. In present study, 1,132 (39.22%) 322...
This study was aimed to investigate the anti-proliferative effect of genistein (Gen) on BCL-6 positive Raji cells and its related mechanism. Trypan blue staining MTT method were used analyze Gen cells. Cell apoptosis, protein expression interaction NCoR detected by PI/AV dual staining, Western blot Co-IP method, respectively. The results showed that had time- dose-dependent inhibitory cell proliferation induced apoptosis. Different dose no significant NCoR, but could inhibit binding NCoR. It...