A5101398821- Erythrocyte Function and Pathophysiology
- Blood groups and transfusion
- Medical Research and Treatments
- Porphyrin Metabolism and Disorders
- Lymphoma Diagnosis and Treatment
- Heme Oxygenase-1 and Carbon Monoxide
- Gastric Cancer Management and Outcomes
- Cancer-related gene regulation
- Dermatologic Treatments and Research
- Genomics and Rare Diseases
- Cancer-related molecular mechanisms research
- Folate and B Vitamins Research
- Genetics and Neurodevelopmental Disorders
- Childhood Cancer Survivors' Quality of Life
- Metastasis and carcinoma case studies
- Blood disorders and treatments
- Lipid metabolism and disorders
- Wound Healing and Treatments
- Skin and Cellular Biology Research
- Platelet Disorders and Treatments
- Neonatal Respiratory Health Research
- Respiratory Support and Mechanisms
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Hematopoietic Stem Cell Transplantation
- Acute Lymphoblastic Leukemia research
Chinese Academy of Medical Sciences & Peking Union Medical College
2014-2024
Peking Union Medical College Hospital
2014-2024
First Affiliated Hospital of Chinese PLA General Hospital
2007
In Brief Objectives: Many mechanically ventilated patients with acute respiratory distress syndrome develop pulmonary fibrosis. Stresses induced by mechanical ventilation may explain the development of fibrosis a number mechanisms (e.g., damage alveolar epithelium, biotrauma). The objective this study was t test hypothesis that plays an important role in pathogenesis lung Methods: C57BL/6 mice were randomized into four groups: healthy controls; hydrochloric acid aspiration alone; vehicle...
ABSTRACT The early gestational fetus heals dermal wounds rapidly and scarlessly. This phenomenon appears to be intrinsic fetal skin is probably modulated by interplay of many genes. We ventured study differences in gene expression between earlier (EGS) later (LGS) with the aid high‐density oligonucleotide DNA array explore molecular mechanism underlying scarless healing. Total RNA was isolated from Wistar rat (E15) scar‐forming (E18) periods gestation (term=21.5 days), purified mRNAs. Both...
To report novel mutations SEC23B gene in congenital dyserythropoietic anemia (CDA).By direct sequencing method, we sequenced CDAN1 and genes a Chinese CDA II patient, presented with chronic fatigue dark urine, as well his family members. Serum hepcidin was assayed by mass spectrometry.We found c.71G>A mutation c.74C> A the patient. In addition, heterozygous c.55A>G of HFE2 some The level serum patient below detection limit (<1 nmol/L).Contrary what have been reported previously Europe,...
To evaluate the safety of polyethylene glycol conjugated L-asparaginase (PEG-Asp) for patients with adult acute lymphoblastic leukemia (ALL) and T cell non-Hodgkin lymphoma (T-NHL).A retrospective analysis was conducted on clinical data 101 young (≤40 years old) ALL T-NHL, diagnosed at Peking Union Medical College Hospital between January 2012 June 2014.A total 480 doses PEG-Asp were administered in 44 cases 57 T-NHL. Only one patient (0.2%) experienced mild allergic reaction. Other grade 3...
Objective To investigate the clinical characteristics and prognostic factors in patients with primary gastric non-Hodgkin lymphoma (PG-NHL).Methods The pathological data of 51 PG-NHL admitted our hospital from 2003 to 2013 were analyzed retrospectively.Results In PG-NHL,there 26 males 25 females.The patients' age ranged 18 80 years old median as 56 old.The survival time was 32 months (range 1 114 months).The oneyear overall (OS),three-year OS five-year 90.2 ％,82.4 ％ 80.4 ％,respectively.The...
Hereditary intrinsic factor deficiency is a rare disease characterized by cobalamin with the lack of gastric because (GIF) mutations. Patients usually present without gastroscopy abnormality and antibodies.A Chinese patient presented recurrent severe anemia since age 2 low level mild elevation indirect bilirubin. The hemoglobin normalized each time after intramuscular vitamin B12 injection. Gene test verified c.776delA frame shift mutation in exon 6 combined c.585C > A nonsense early...