A5062291677- Herpesvirus Infections and Treatments
- Chronic Lymphocytic Leukemia Research
- Advanced Breast Cancer Therapies
- Plant Virus Research Studies
- Cancer-related Molecular Pathways
- Chronic Myeloid Leukemia Treatments
- Endometriosis Research and Treatment
- Lipoproteins and Cardiovascular Health
- Cytomegalovirus and herpesvirus research
- Reproductive System and Pregnancy
- Cancer, Lipids, and Metabolism
- PI3K/AKT/mTOR signaling in cancer
- Neuroendocrine Tumor Research Advances
- Endometrial and Cervical Cancer Treatments
- Cancer Treatment and Pharmacology
- Uterine Myomas and Treatments
- Liver Disease Diagnosis and Treatment
- Colorectal Cancer Treatments and Studies
- Ginseng Biological Effects and Applications
- Neuroblastoma Research and Treatments
- Lung Cancer Treatments and Mutations
- Lipid metabolism and disorders
- Pharmacological Effects of Natural Compounds
- Glioma Diagnosis and Treatment
- Cancer Genomics and Diagnostics
Wuhan University
2024
Zhongnan Hospital of Wuhan University
2024
The Affiliated Yongchuan Hospital of Chongqing Medical University
2019-2023
Chongqing Medical University
2019-2023
Guangzhou Medical University
2016-2022
Memorial Sloan Kettering Cancer Center
2002-2022
Center for Excellence in Molecular Plant Sciences
2018-2021
Chinese Academy of Sciences
2018-2021
University of Chinese Academy of Sciences
2018-2021
Merck & Co., Inc., Rahway, NJ, USA (United States)
2010-2019
Dinaciclib, a small-molecule, cyclin-dependent kinase inhibitor, inhibits cell cycle progression and proliferation in various tumor lines vitro. We conducted an open-label, dose-escalation study to determine the safety, tolerability, bioactivity of dinaciclib adults with advanced malignancies. Dinaciclib was administered starting at dose 0.33 mg/m2, as 2-hour intravenous infusion once weekly for 3 weeks (on days 1, 8, 15 28-day cycle), maximum (MAD), dose-limiting toxicities (DLTs),...
Ezetimibe [SCH 58235; 1-(4-fluorophenyl)-3(R)-[3-(4-fluorophenyl)-3(S)-hydroxypropyl]-4(S)-(4-hydroxyphenyl)-2-azetidinone], a selective cholesterol absorption inhibitor, is being developed for the treatment of primary hypercholesterolemia. The absorption, metabolism, and excretion ezetimibe were characterized in eight healthy male volunteers this single-center, single-dose, open-label study. Subjects received single oral 20-mg dose [14C]ezetimibe (approximately 100 microCi) with 200 ml...
Dinaciclib inhibits cyclin-dependent kinases 1, 2, 5, and 9 with a better therapeutic index than flavopiridol in preclinical studies. This study assessed the activity of dinaciclib acute leukemia both clinic vitro.Adults relapsed/refractory myeloid (n = 14) lymphoid 6) were treated 50 mg/m(2) given as 2-h infusion every 21 days.Most patients had dramatic but transient reduction circulating blasts; however, no remissions achieved on this schedule. The most common toxicities gastrointestinal,...
Most legume plants can associate with diazotrophic soil bacteria called rhizobia, resulting in new root organs nodules that enable N2 fixation. Nodulation is an energy-consuming process, and nodule number tightly regulated by independent systemic signaling pathways controlled CLE/SUNN CEP/CRA2. Moreover, nitrate inhibits nodulation via local regulatory pathways. In Medicago truncatula, NLP1 plays important roles nitrate-induced inhibition of nodulation, but the relationship between mediating...
Abstract Increasing evidence indicates that the phloem mediates traffic of selective RNAs within a plant. How an RNA enters, moves in, and exits is poorly understood. Potato spindle tuber viroid (PSTVd) pathogenic does not encode proteins encapsidated, yet it replicates autonomously traffics systemically infected The genome must interact directly with cellular factors to accomplish these functions is, therefore, excellent probe study mechanisms regulate traffic. Our analyses PSTVd in...
Dinaciclib is a potent inhibitor of cell cycle and transcriptional cyclin-dependent kinases. This Phase 1 study evaluated the safety, tolerability pharmacokinetics various dosing schedules dinaciclib in advanced solid tumour patients assessed pharmacodynamic preliminary anti-tumour activity. In part 1, were enrolled escalating cohorts 2-h infusions administered once every 3 weeks, utilising an accelerated titration design until recommended phase 2 dose (RP2D) was defined. 2, 8- 24-h...
To establish the maximum tolerated dose of lonafarnib, a novel farnesyltransferase inhibitor, in combination with paclitaxel patients solid tumors and to characterize safety, tolerability, dose-limiting toxicity, pharmacokinetics this regimen.In Phase I trial, lonafarnib was administered p.o., twice daily (b.i.d.) on continuously scheduled doses 100 mg, 125 150 mg i.v. at 135 mg/m(2) or 175 over 3 h day 8 every 21-day cycle. Plasma concentrations were collected selected time points from each...
A dose-escalation phase I and pharmacokinetic study of the farnesyltransferase inhibitor lonafarnib (SCH66336) was conducted in children with recurrent or progressive CNS tumors. Primary objectives were to estimate maximum-tolerated dose (MTD) describe dose-limiting toxicities (DLTs) pharmacokinetics lonafarnib. Farnesylation inhibition HDJ-2 peripheral blood also measured.Lonafarnib administered orally twice daily at levels 70, 90, 115, 150, 200 mg/m2/dose bid. modified continual...
Intercellular communication is essential for differentiation and development. In plants, plasmodesmata (PD) form cytoplasmic channels direct communication. During plant development, programmed reduction in PD number transport capacity creates the so-called symplasmic domains. Small fluorescent dyes ions can diffuse among cells within a domain but not across boundaries. Such isolation thought to allow groups of differentiate develop into tissues with distinct structures functions. Whether or...
SUMMARYBackground: Ezetimibe is a lipid-lowering drug indicated for the treatment of hypercholesterolemia as co-administration with HMG-CoA reductase inhibitors (statins) or monotherapy. The primary objectives this study were to evaluate pharmacodynamic effects and safety ezetimibe new statin rosuvastatin. A secondary objective was examine potential pharmacokinetic interaction between rosuvastatin.Methods: This randomized, evaluator (single)-blind, placebo-controlled, parallel-group in...
Lonafarnib is an orally bioavailable nonpetidomimetic farnesyl transferase inhibitor with significant activity against BCR-ABL-positive cell lines and primary human chronic myeloid leukemia (CML) cells. can inhibit the proliferation of imatinib-resistant cells increases imatinib-induced apoptosis in vitro from patients.The authors conducted a phase 1 study lonafarnib combination imatinib patients CML who failed therapy. The starting dose level for (CP) disease was imatinib, 400 mg/day, plus...
Oral temozolomide is approved in many countries for malignant glioma and melanoma some outside the USA. This study evaluated exposure equivalence safety of by intravenous infusion oral administration.Subjects with primary central nervous system malignancies (excluding lymphoma) received 200 mg/m(2) on days 1, 2 5. On 3 4, subjects 150 either as a 90-min one day or administration an alternate day.Ratio log-transformed means (intravenous:oral) area under concentration-time curve maximum...
Is chloride channel-3 (ClC-3) involved in regulating the biological behavior of endometrial stromal cells (ESCs)? ClC-3 promotes endometriotic cell migration and invasion. plays a significant role invasion various kinds cells. An vitro investigation effect on ectopic ESCs from patients with endometriosis. The eutopic samples 43 female endometriosis 39 non-endometriotic were collected. Primary these isolated cultured. Real-time RT–PCR, immunohistochemistry western blot used to detect...
Endometriosis is a common gynecological disease with manifestations of endometrial-like tissue outside the uterus. Transforming growth factor-β (TGF-β) known to facilitate series biological events in many cells, including migration. However, roles TGF-β endometriosis still remain largely unknown. The aim present study was discover role TGF-β1 development and progression its associated mechanisms. It demonstrated that expression significantly elevated comparison normal tissue. Overexpression...
Ebola virus (EBOV) causes a lethal hemorrhagic fever for which there is no approved effective treatment or prevention strategy. EBOV VP35 virulence factor that blocks innate antiviral host responses, including the induction of and response to alpha/beta interferon. also an RNA silencing suppressor (RSS). By inhibiting microRNA-directed silencing, mammalian RSSs have capacity alter cellular environment benefit replication. A reporter gene containing specific microRNA target sequences was used...
Transient gene expression systems using protoplasts have been widely used for rapid functional characterization of genes and high-throughput analysis in many model crop species. Here, we describe a simplified highly efficient root protoplast isolation transient system the legumes Lotus japonicus Medicago truncatula. Firstly, presented an protocol isolating from L. M. truncatula roots. We then established these protoplasts. Using this protocol, subcellular localization two symbiosis related...
Abstract STUDY QUESTION What is the expression level of T-cadherin in endometriosis, and does play a role regulating invasion migration endometrial stromal cells? SUMMARY ANSWER was reduced ectopic endometriotic lesions compared to eutopic endometrium, overexpression inhibited cells. WHAT IS KNOWN ALREADY Endometriosis disease that involves active cell migration. can inhibit invasion, proliferation various cancer cells, but its endometriosis has not been investigated. DESIGN, SIZE, DURATION...
Abstract Ginsenoside Rg1 (G-Rg1) is a bioactive phytochemical that has been found to be beneficial for the treatment of several diseases including nonalcoholic fatty liver disease (NAFLD). But there lack literature reporting effect G-Rg1 on lipid metabolism balance in NAFLD. We investigated and mechanism vitro. decreased levels TG, TC, MDA, increased activity SOD. Results RT-PCR western blotting showed supplementation with downregulated expression PPAR γ, FABP1, FATP2/5, CD36, SREBP1 c,...