A5100942633- Pregnancy and preeclampsia studies
- Reproductive System and Pregnancy
- Cancer Cells and Metastasis
- Transplantation: Methods and Outcomes
- Zeolite Catalysis and Synthesis
- Fibroblast Growth Factor Research
- Renal and related cancers
- Protist diversity and phylogeny
- Maternal and fetal healthcare
- Immune Cell Function and Interaction
- Birth, Development, and Health
- Cell Adhesion Molecules Research
- Endometriosis Research and Treatment
- Angiogenesis and VEGF in Cancer
- Organ Transplantation Techniques and Outcomes
- Immunotherapy and Immune Responses
- Pineapple and bromelain studies
- Organ and Tissue Transplantation Research
- Gestational Trophoblastic Disease Studies
- Preterm Birth and Chorioamnionitis
- Extracellular vesicles in disease
- NF-κB Signaling Pathways
- Garlic and Onion Studies
- Gastrointestinal disorders and treatments
- TGF-β signaling in diseases
Guangzhou Medical University
2016-2025
Guangzhou Women and Children Medical Center
2016-2024
Ningxia University
2023
Hunan International Economics University
2023
Xinjiang Medical University
2017
First Affiliated Hospital of Xinjiang Medical University
2017
Sun Yat-sen University
2012-2015
Guangxi Maternal and Child Health Hospital
2013
Fusobacterium nucleatum (F. nucleatum, Fn) is associated with the colorectal cancer (CRC). Fn-infection could induce significant levels of serum Fn-specific antibodies in human and mice. The objective this study was to identify that elicit a humoral response patients CRC evaluate diagnostic performance anti-Fn antibodies. In work, we showed mean absorbance value anti-Fn-IgA -IgG group were significantly higher than those benign colon disease healthy control (P < 0.001). sensitivity...
<ns4:p>Gestational trophoblastic disease or neoplasia covers a spectrum of benign and malignant conditions arising from pregnancies with highly abnormal development tissue. In this brief review, we discuss the different features these their origins risk factors introduce some more novel controversial treatment options currently being explored.</ns4:p>
Abstract Background Immunotherapy has been shown to be a promising strategy against human cancers. A better understanding of the immune regulation in hepatocellular carcinoma (HCC) could help development immunotherapy HCC. The epidermal growth factor receptor (EGFR) signaling is frequently activated HCC and plays important roles tumorigenesis. However, its role immunity still largely unknown. This study aimed investigate impact EGFR on programmed death‐ligand 1 (PD‐L1) leukocyte antigen...
Abstract During uterine spiral artery remodeling, vascular smooth muscle cells (VSMCs) become disorganized and undergo phenotypic switching from a contractile to more synthetic phenotype. We have previously reported that natural killer induce this VSMC by secreting angiopoietin‐2 (Ang‐2). Here, we identified the specific mechanisms which Ang‐2 plays role in phenomenon. VSMCs isolated human umbilical arteries were used as an vitro model investigate of switching. Human decidua tissue...
Purpose Cancer-associated fibroblasts (CAFs) activated by cancer cells has a central role in development and malignant biological behavior colorectal (CRC). Adult do not express Snail, but Snail-positive are discovered the stroma of CRC reported to be key chemoresistance. However, reciprocal effect CAFs expressed Snail chemoresistance on underlying molecular mechanisms fully characterized. Materials Methods Snail-overexpressed 3T3 stable cell lines were generated lipidosome CT26 mixed with...
Abstract Better understanding of metastasis process would allow for the development effective approaches to treat hepatocellular carcinoma (HCC). Recent literature has highlighted fundamental role interaction between tumor cells and their microenvironment components in metastasis. Aberrant expression epidermal growth factor (EGF) induces highly malignant HCC, activated EGF/EGFR signaling is correlated with an aggressive phenotype intrahepatic Thus, EGF may influence behavior HCC cells. In...
The use of cytolytic peptides with potential therapeutic properties is a promising approach to cancer therapy due their convenient automated synthesis and capacity for modifications. However, the limited nonspecific activity. In this study, we designed tumor-targeting proapoptotic system based on an amphipathic D-amino acid-modified apoptotic peptide, KLA, variant (KLAKLAK)2, which fused linear tumor-penetrating homing peptide iRGD through specific cathepsin B (CTSB) cleavage sequences that...
Abstract STUDY QUESTION What is the expression level of T-cadherin in endometriosis, and does play a role regulating invasion migration endometrial stromal cells? SUMMARY ANSWER was reduced ectopic endometriotic lesions compared to eutopic endometrium, overexpression inhibited cells. WHAT IS KNOWN ALREADY Endometriosis disease that involves active cell migration. can inhibit invasion, proliferation various cancer cells, but its endometriosis has not been investigated. DESIGN, SIZE, DURATION...
Vitamin D deficiency is associated with complications of pregnancy such as pre-eclampsia, fetal growth restriction, and miscarriage, all which are also incomplete spiral artery (SpA) remodeling. We have previously shown that both uterine natural killer (uNK) cells extravillous trophoblast (EVT) required for successful SpA remodeling, but whether their activity in this process modulated by vitamin not known. In the current study, we use a described chorionic plate (CPA) ex vivo model vascular...
Abstract Extravillous trophoblast cell (EVT) invasion is tightly controlled, and its dysregulation can lead to altered spiral artery remodeling contribute a number of different pregnancy complications. Angiopoietin-2 (Ang-2) expressed by cells various in the decidua, express receptor, Tie2. Ang-2 has been shown play roles tumor progression metastasis but it not known if also regulates EVT invasion. Here, we show that both HTR-8/SVneo line primary isolates human integrins Tie2 stimulated...
Endometrial cancer (EC) is the most common gynecological cancer, and one of important causes cancer‑related deaths in women worldwide. The long‑term survival rate lower advanced‑stage recurrent EC, therefore it to identify new anticancer drugs. Garcinol, a polyisoprenylated benzophenone, promising drug for various types but its effects on EC remain unclear. To investigate garcinol cell proliferation cycle were assessed by real‑time proliferation, counting, colony formation assays, flow...
Abstract The remodeling of uterine spiral arteries is a complex process requiring the dynamic action various cell types. During early pregnancy, extravillous trophoblast (EVT) cells differentiate and invade vascular wall, replacing smooth muscle (VSMCs). Several in vitro studies have shown that EVT play an important role promoting VSMC apoptosis, however, mechanism underlying this not fully understood. In study, we demonstrated EVT-conditioned media EVT-derived exosomes could induce...