A5100403383- Cancer Cells and Metastasis
- Wnt/β-catenin signaling in development and cancer
- Fibroblast Growth Factor Research
- Cancer, Stress, Anesthesia, and Immune Response
- Metastasis and carcinoma case studies
- Cancer Genomics and Diagnostics
- interferon and immune responses
- Neurofibromatosis and Schwannoma Cases
- HER2/EGFR in Cancer Research
- Sepsis Diagnosis and Treatment
- Gut microbiota and health
- Organ Transplantation Techniques and Outcomes
- Signaling Pathways in Disease
- Cardiac Ischemia and Reperfusion
- FOXO transcription factor regulation
- Multiple and Secondary Primary Cancers
- Cancer Risks and Factors
- Sympathectomy and Hyperhidrosis Treatments
- Head and Neck Cancer Studies
- Diagnosis and treatment of tuberculosis
- Cardiac electrophysiology and arrhythmias
- Marine Sponges and Natural Products
- MicroRNA in disease regulation
- Transplantation: Methods and Outcomes
- Lung Cancer Diagnosis and Treatment
Wuhan University
2010-2024
Renmin Hospital of Wuhan University
2010-2024
Sun Yat-sen University
2013-2023
Viva Biotech (China)
2023
Fifth Affiliated Hospital of Sun Yat-sen University
2023
Guangxi University of Chinese Medicine
2023
Tianjin Medical University Cancer Institute and Hospital
2023
Capital University
2022
Capital Medical University
2022
Tumor Hospital of Guangxi Medical University
2021
Chronic inflammation-promoted metastasis has been considered as a major challenge in cancer therapy. Pro-inflammatory cytokine TNFα can induce invasion and associated with epithelial–mesenchymal transition (EMT). However, the underlying mechanisms are not entirely clear. In this study, we showed that induces EMT human HCT116 cells thereby promotes colorectal (CRC) metastasis. TNFα-induced was characterized by acquiring mesenchymal spindle-like morphology increasing expression of N-cadherin...
Overexpression of Twist, a highly conserved basic helix-loop-helix transcription factor, is associated with epithelial-mesenchymal transition (EMT) and predicts poor prognosis in various kinds cancers, including breast cancer. In order to further clarify Twist's role cancer, we detected Twist expression cancer tissues by immunohistochemistry. was observed 54% (220/408) patients positively tumor size, Ki67, VEGF-C HER2 expression. Conversely, negatively estrogen receptor (ER), progesterone...
Epithelial-mesenchymal transition (EMT) is a crucial process providing cancer cells with the ability to migrate and metastasize distant sites. Recently, EMT was shown be associated stem cell (CSC) phenotype chemoresistance. Twist transcription factor that regulates in various cells, including colorectal (CRC). Our study done determine role of mediating aggressive CRC. Human CRC lines were transduced retroviral construct or vector control. Migration invasion abilities determined vitro using...
Improving the specific capture efficiency of CTCs, and meanwhile preventing nonspecific adsorption surrounding background cells, is main focus CTCs detection. Herein, a novel biomimetic microfluidic system was developed by combining unique benefits nanoparticles techniques. The magnetic nanoclusters were camouflaged with leukocyte membrane fragments decorated aptamer SYL3C for EpCAM positive tumor cells then loaded into chip help magnets. By use this system, more than 90% rare in blood could...
Osteopetrosis (OPT) refers to the consequences of generalized failure skeletal resorption during growth. Most cases are explained by loss-of-function mutation within genes that encode either chloride channel 7 (CLCN7) or a vacuolar proton pump subunit (TCIRG1), each compromising acid secretion osteoclasts. Patients suffer fractures and sometimes cranial nerve entrapment insufficient medullary space for hematopoiesis. In 1996, we reported high serum level brain isoenzyme creatine kinase...
Mechanism of high fat diet-induced obesity is analyzed and serum tumor necrosis factor, malondialdehyde glutathione levels resistant rats are effectively analyzed.
Tumours are more likely to metastasize after the development of resistance EGFR-TKIs. CD146 is a multifunctional molecule and implicated in tumour invasion metastasis; however, its role lung cancer has not been clearly established.Here, we aimed explore relationship between pathway stem cell phenotype EGFR-TKI cancer.EGFR-TKI-resistant lines were established by exposing parental cells erlotinib/gefitinib. The level was measured western blot, RT-PCR immunocytochemistry fluorescent. Cell...
Background. Infective endocarditis (IE) is a complex infectious disease with high morbidity and mortality. The inflammation mechanism of IE network including interactions inflammatory cytokines other components host response. As an important marker, the prediction ability neutrophil-to-lymphocyte ratio (NLR) in deserves further investigation. Methods. NLR values were measured compared between patients healthy controls, good bad clinical outcome groups. receiver operating characteristic...
Heart failure with reduced ejection fraction (HFrEF) is a major health concern globally due to high mortality rates, frequent hospitalization and considerable medical expenditure. The prevalence of HFrEF steadily rising in Asian countries, populous, developing countries like China are facing significant socio-economic burden as result. Sacubitril-valsartan (Sac-Val) currently class I recommendation for treating guidelines, although it has not been pharmaco-economically evaluated China. To...
A few studies have reported the distribution of microbiota in breast cancer tissues, but reports compared different subtypes tissue. Moreover, no study has on relationship between and gene expression tumor.Sections formalin-fixed paraffin-embedded (FFPE) tissue were prepared from tumors 70 patients subjected to microarray analysis identify profiles. The same total RNA samples also used analyze activity tumor tissues by performing 16 S rRNA sequencing internal transcribed spacer (ITS) reverse...
SOX18 is a potential oncogene in osteosarcoma via controlling cell proliferation and metastasis. Interleukin-6 (IL-6), major activator of Janus kinase 2 (JAK2)/signal transducers activators transcription 3 (STAT3) signaling, plays an important role the growth carcinoma cells. The present study aims to investigate correlation between IL-6 osteosarcoma.Protein expression mRNA were determined by Western blot real-time polymerase chain reaction (PCR) analysis, respectively. Cell apoptosis...
Aims: Changes in myocardial mitochondrial morphology and function premature ventricular contractions (PVCs)-induced cardiomyopathy (PVCCM) remain poorly studied. Here, we investigated the effects of PVCs with different coupling intervals (CIs) on remodelling a canine model PVCCM. Methods Results: Twenty-one beagles underwent pacemaker implantation were randomised into sham (n = 7), short-coupled (SCP, n long-coupled (LCP, 7) groups. Right (RV) apical bigeminy was produced for 12-week to...
Abstract Patients with axillary lymph node metastasis after radical radiotherapy for nasopharyngeal carcinoma are clinically visible, and the reasons this condition unclear. We conducted a retrospective study on small sample to explore characteristics of metastasis. reviewed all patients admitted our department from 2015 2020 selected 6 who developed treatment. These belonged N3 stage before treatment, occurred in area same or more severely affected side supraclavicular From occurrence time...
Colorectal cancer (CRC) is the fifth most fatal with a low probability of surgery and limited treatment options, especially in metastatic CRC. In this study, we investigated whether mouse model CRC mimicked tumor progression evaluated effect 5-fluorouracil (5-FU) treatment.The CT26 derived cell line was inoculated into mice, bearing mice were divided two groups: experimental group control group. Micro-computed tomography (CT) vivo fluorescence used to monitor A lung metastasis employed...