A5106667660- Breast Cancer Treatment Studies
- Respiratory viral infections research
- Cancer Immunotherapy and Biomarkers
- HER2/EGFR in Cancer Research
- Lymphoma Diagnosis and Treatment
- Cancer Cells and Metastasis
- Male Breast Health Studies
- BRCA gene mutations in cancer
- Multiple and Secondary Primary Cancers
- Immune Cell Function and Interaction
- Viral-associated cancers and disorders
- Immunotherapy and Immune Responses
- Immune cells in cancer
- Head and Neck Cancer Studies
- Breast Lesions and Carcinomas
- Epigenetics and DNA Methylation
- Estrogen and related hormone effects
- Ferroptosis and cancer prognosis
- Medical Imaging Techniques and Applications
- Breast Implant and Reconstruction
- Cancer Research and Treatments
- Monoclonal and Polyclonal Antibodies Research
- Tea Polyphenols and Effects
- Histone Deacetylase Inhibitors Research
- Advanced Fluorescence Microscopy Techniques
Shantou Central Hospital
2021-2025
China Medical University
2024
Renji Hospital
2024
Shanghai Jiao Tong University
2024
University of Groningen
2018-2023
Shantou University
2013-2023
Cancer Hospital of Shantou University Medical College
2013-2023
University Medical Center Groningen
2017-2023
Guangxi University
2022
Abstract Among patients with a preoperative positive axillary ultrasound, around 40% of them are pathologically proved to be free from lymph node (ALN) metastasis. We aimed develop and validate model predict the probability ALN metastasis as tool support clinical decision-making. Clinicopathological features 322 early breast cancer ultrasound findings were analyzed. Multivariate logistic regression analysis was performed identify independent predictors A created analysis, comprising...
Overexpression of Twist, a highly conserved basic helix-loop-helix transcription factor, is associated with epithelial-mesenchymal transition (EMT) and predicts poor prognosis in various kinds cancers, including breast cancer. In order to further clarify Twist's role cancer, we detected Twist expression cancer tissues by immunohistochemistry. was observed 54% (220/408) patients positively tumor size, Ki67, VEGF-C HER2 expression. Conversely, negatively estrogen receptor (ER), progesterone...
The chemokine CXCL9 (C-X-C motif ligand 9) has been reported to be required for antitumour immune responses following checkpoint blockade. In this study, we sought investigate the potential value of according in patients with breast cancer (BC). A variety open-source databases and online tools were used explore expression features prognostic significance BC its correlation immune-related biomarkers followed by subsequent verification immunohistochemistry experiments. mRNA level was found...
Introduction: Early predictive pathological complete response (pCR) is beneficial for optimizing neoadjuvant chemotherapy (NAC) strategies breast cancer. The hematoxylin and eosin (HE)-stained slices of biopsy tissues contain a large amount information on tumor epithelial cells stromal. fusion image features clinicopathological expected to build model predict pCR NAC in Methods: We retrospectively collected total 440 cancer patients from three hospitals who underwent NAC. HE-stained were...
Bismuth sulfide@bismuth nanorods (Bi2S3@Bi NRs) have emerged as promising photodynamic therapeutic agents due to Bi2S3@Bi being able produce reactive oxygen species from self-supplied O2. Combining photothermal and therapies with chemotherapy is attractive but difficult achieve. Here, we develop a subtle method wrap NRs mesoporous polydopamine, where drug doxorubicin hydrochloride can be loaded, thus providing multifunctional antitumor nanospheres. To our delight, the prepared...
The number of M1-like and M2-like tumour-associated macrophages (TAMs) their ratio can play a role in breast cancer development progression. Early clinical trials using macrophage targeting compounds are currently ongoing. However, the most optimal detection method subsets relevance is still unclear. We aimed to optimize assessment TAM different subtypes, therefore related subset numbers clinicopathological characteristics outcome.Tissue microarrays 347 consecutive primary Luminal-A,...
// Xiao-Long Wei 1, 2 , Xiao-Wei Dou Jing-Wen Bai Xiang-Rong Luo Si-Qi Qiu 3 Di-Di Xi Wen-He Huang Cai-Wen Du 4 Kwan Man 5 Guo-Jun Zhang 2, 1 Department of Pathology, Cancer Hospital Shantou University Medical College, 515031, China Changjiang Scholar's Laboratory and Research Center, The Breast Oncology, Surgery Transplantation, Li Ka Shing Faculty Medicine, Hong Kong University, 999077, Correspondence to: Zhang, e-mail: guoj_zhang@yahoo.com Keywords: ERα signaling, epithelial-mesenchymal...
Nasopharyngeal carcinoma (NPC) is prevalent in Southern China and Southeast Asia, autoantibody signatures may improve early detection of NPC. In this study, serum levels autoantibodies against a panel six tumor-associated antigens (p53, NY-ESO-1, MMP-7, Hsp70, Prx VI, Bmi-1) Epstein-Barr virus capsid antigen-IgA (VCA-IgA) were tested by enzyme-linked immunosorbent assay training set (220 NPC patients 150 controls) validated validation (90 68 controls). We used receiver-operating...
Breast cancer in young women is typically with higher proportion of adverse pathological features. BRCA1 mutation often early-onset, and usually associated triple negative phenotpe. In this study, we aim to analyze the clinicopathological characteristics prognosis breast patients (≤35 years old) comparing non-young (>35 old). A total 1913 cases primary carcinoma stage I-III were enrolled, 283 diagnosed as patients. No significant difference was observed tumor size, TNM staging, lymph node...
Liupao tea is an important dark tea, but few studies on purified polysaccharide (TPS) are reported in the literature. In this study, two TPSs, named TPS2 and TPS5, with molecular weights of 70.5 133.9 kDa, respectively, were from tea. contained total sugar content (53.73% ± 1.55%) uronic acid (35.18% 0.96%), while TPS5 was made up (51.71% 1.1%), (40.95% 3.12%), polyphenols (0.43% 0.03%), proteins (0.11% 0.07%). composed Man, Rha, GlcA, Glc, Gal, Ara molar ratios...
Patients who achieve a tumor pathologic complete response (pCR) after neoadjuvant chemotherapy (NAC) have better outcomes than patients with residual tumor. However, tumors still recur in the pCR patients. Therefore, we aim to explore factors associated recurrence this patient population.A total of 1,913 diagnosed breast cancer between 1995 and 2020 received NAC were included analysis. Clinicopathological data retrospectively collected. We used Cox regression analysis assess associations...
Oral cancer represents a serious public health problem affecting oral and system with high global incidence. Treatment strategies for vary in different disciplines are likely to be limited certain doctor's personal experience. While clinical practice guidelines considered enable doctors determine the most appropriate consistent treatment strategy according patient's situation. National Comprehensive Cancer Network (NCCN) have become prevalent oncology practice. This article mainly focuses on...
Immune checkpoint blockade (ICB) has been improving the patient outcome in multiple cancer types. However, not all patients respond to ICB. Biomarkers are needed for selecting appropriate receive CD74 is an important chaperone that regulates antigen presentation immune response. relationship between expression and ICB response remains elusive.