A5005533554- Epigenetics and DNA Methylation
- Cancer Cells and Metastasis
- Cancer-related molecular mechanisms research
- Cancer, Lipids, and Metabolism
- Metastasis and carcinoma case studies
- Cancer-related gene regulation
- Ferroptosis and cancer prognosis
- Cancer Risks and Factors
- Renal and related cancers
- Wnt/β-catenin signaling in development and cancer
- RNA modifications and cancer
- Hippo pathway signaling and YAP/TAZ
- Drug Transport and Resistance Mechanisms
- Cancer, Hypoxia, and Metabolism
- Cancer Treatment and Pharmacology
- Cancer Genomics and Diagnostics
- Global Cancer Incidence and Screening
- Gene expression and cancer classification
- Adenosine and Purinergic Signaling
- HER2/EGFR in Cancer Research
- Peroxisome Proliferator-Activated Receptors
- Genomics and Chromatin Dynamics
- Breast Cancer Treatment Studies
- Antibiotic Resistance in Bacteria
- Biomedical Text Mining and Ontologies
Guiyang College of Traditional Chinese Medicine
2025
Cancer Hospital of Shantou University Medical College
2015-2024
Shantou University
2015-2024
Shantou University Medical College
2016-2024
China Southern Power Grid (China)
2024
Beijing Great Wall Hospital
1992
Chromobox (CBX) family proteins are canonical components in polycomb repressive complexes 1 (PRC1), with epigenetic regulatory function and transcriptionally repressing target genes via chromatin modification. A plethora of studies have highlighted the specifications among CBX members various cancer, including lung colon cancer breast cancer. Nevertheless, functions prognostic roles distinct (BC) remain elusive. In this study, we reported values patients BC through analysis a series...
Resistance to chemotherapy remains a significant problem in the treatment of breast cancer, especially for triple-negative cancer (TNBC), which standard systemic therapy is currently limited chemotherapeutic agents. Our study aimed better understand molecular mechanisms that lead failure TNBC. Herein, we observed elevated expression Notch1 and major vault protein (MVP) MDA-MB-231DDPR cells compared their parental counterparts. We demonstrated could positively regulate MVP. Also,...
Resistance to chemotherapy continues be a critical issue in the clinical therapy of triple-negative breast cancer (TNBC). Epithelial-mesenchymal transition (EMT) is thought contribute chemoresistance several types, including cancer. Identification key signaling pathway that regulates EMT program and contributes TNBC will provide novel strategy overcome this subtype Herein, we demonstrate Notch1 positively associates with melanoma cell adhesion molecule (MCAM), unique activator, tissue...
The chemokine CXCL9 (C-X-C motif ligand 9) has been reported to be required for antitumour immune responses following checkpoint blockade. In this study, we sought investigate the potential value of according in patients with breast cancer (BC). A variety open-source databases and online tools were used explore expression features prognostic significance BC its correlation immune-related biomarkers followed by subsequent verification immunohistochemistry experiments. mRNA level was found...
Tamoxifen resistance presents a prominent clinical challenge in endocrine therapy for hormone sensitive breast cancer. However, the underlying mechanisms that contribute to tamoxifen are not fully understood. In this study, we established resistant MCF-7 cell line (MCF-7-Tam-R) by continuously incubating cells with 4-OH-tamoxifen. We found melanoma adhesion molecule (MCAM/CD146), unique epithelial-to-mesenchymal transition (EMT) inducer, was significantly up-regulated at both mRNA and...
Notch receptors (Notch1-4) play critical roles in tumorigenesis and metastasis of malignant tumors, including breast cancer. Although abnormal activation is related to various the importance single their mechanism distinct cancer subtypes are still unclear. Previous studies by our group demonstrated that Notch3 may inhibit emergence progression PTEN a potent tumor suppressor, its loss function sufficient promote occurrence tumors. Intriguingly, numerous have revealed Notch1 involved...
Radiotherapy is an indispensable modality in comprehensive treatment of breast cancer. However, inherent or acquired radiation resistance tumors compromises the efficacy radiotherapy. Herein, we found that CD146, a unique epithelial-to-mesenchymal transition (EMT) inducer particularly highly expressed triple-negative cancer (TNBC), dramatically induced by ionizing irradiation. Further study demonstrates CD146 promotes tumor cell radioresistance vitro and vivo. Specifically, report underlying...
Methicillin-resistant Staphylococcus aureus (MRSA) achieves high-level resistance against β-lactam antibiotics through the expression of penicillin-binding protein 2a (PBP2a), which features a closed active site that impedes antibiotic binding. Herein, we implemented strategy combines drug repurposing with synergistic therapy to identify potential inhibitors targeting PBP2a's allosteric from an FDA-approved database. Initially, retrospective verifications were conducted, employing different...
GATA transcription factors are zinc finger DNA binding proteins that activate during development and cell differentiation. To date, 7 members of family have been reported. However, the expression patterns exact roles distinct contributing to tumorigenesis progression breast cancer (BC) remain be elucidated. Here, we studied transcripts in a variety tumor types compared with normal controls using ONCOMINE GOBO databases, along their corresponding profiles an array lines through CCLE analysis....
Notch3 and GATA binding protein 3 (GATA-3) have been, individually, shown to maintain luminal phenotype inhibit epithelial-mesenchymal transition (EMT) in breast cancers. In the present study, we report that expression positively correlates with of GATA-3, both are associated estrogen receptor-α (ERα) cancer cells. We demonstrate vitro vivo suppressed EMT metastasis by activating GATA-3 transcription. Furthermore, knockdown downregulated promoted EMT; while overexpression intracellular...
// Xiao-Feng Lu 1, * , De Zeng 2, Wei-Quan Liang 1 Chun-Fa Chen Shu-Ming Sun and Hao-Yu Lin Department of Breast Thyroid Surgery, The First Affiliated Hospital Shantou University Medical College, Shantou, China 2 Oncology, Cancer These authors contributed equally to this work Correspondence to: Lin, email: Rainlhy@stu.edu.cn Keywords: FoxM1, breast cancer; prognostic values Received: August 28, 2017 Accepted: November 16, Published: December 12, ABSTRACT Forkhead box protein M1(FoxM1) is a...
Growing evidence has indicated that the long noncoding RNA H19 (lncRNA H19), frequently deregulated in almost all tumor types tested, acted as a pivotal contributor to both cancer initiation and progression. However, role of lncRNA human papillary thyroid carcinoma (PTC) remains controversial. The aim study was investigate expression potential function PTC.The level determined by quantitative real-time (RT)-PCR analyses 58 PTC tissue samples their paired paracancerous samples. interference,...
Introduction: Axillary lymph nodes (ALN) status is an essential component in tumor staging and treatment planning for patients with breast cancer. The aim of present study was to evaluate the predictive value preoperative multidetector-row computed tomography (MDCT) ALN metastasis cancer patients. Methods: A total 148 cases underwent MDCT examination surgery were eligible study. Logistic regression analysis variates used estimate independent factors metastasis. prediction determined through...
Resistance to tamoxifen remains a prominent conundrum in the therapy of hormone-sensitive breast cancer. Also, molecular underpinnings leading resistance remain unclear. In present study, we utilized Gene Expression Omnibus database identify that SOX11 might exert pivotal function conferring was found be markedly upregulated at both messenger RNA and protein levels established MCF-7-Tam-R cells compared parental counterparts. Moreover, able activate transcription slug via binding its...
Background Short videos on social media are playing an increasingly important role in cancer health education today. It is to explore how the actual communication effect of and knowledge absorption users influenced by different factors video creation process. Objective The objective our study access influencing breast through short efficiency quality. Methods Three pairs about were created participants completed questionnaires before after watching videos. A paired t -test was used analyze...
Triple-negative breast cancer (TNBC) is an aggressive molecular subtype that due to lack of druggable targets treated with chemotherapy as standard care. However, TNBC prone chemoresistance and associates poor survival. The aim this study was explore the mechanisms in TNBC. Firstly, we found mRNA expression Notch1 CD73 cisplatin-treated patient material associated clinical outcome. Further, both were upregulated at protein level cisplatin-resistant cell lines. Overexpression intracellular...
RNA-binding proteins (RBPs) refer to a class of that participate in alternative splicing, RNA stability, polyadenylation, localization and translation RNAs, thus regulating gene expression post-transcriptional manner. Dysregulation RNA-RBP interaction contributes various diseases, including cancer. In breast cancer, disorders RBP function influence the biological characteristics tumor cells. Targeting RBPs has fostered development innovative therapies for However, RBP-related mechanisms...
Background: NPM1 is a multifunctional phosphoprotein that commutes between the cytoplasm and nucleus in cell cycle process, which appears to be actively involved tumorigenesis. Herein, we sought investigate possible role prognostic value of triple-negative breast cancer (TNBC). Methods: An array public databases, including bc-GenExMiner v4.0, GOBO, GEPIA, UALCAN, ONCOMINE database Kaplan-Meier plotter, were used expression feature potential function TNBC. Immunohistochemistry,...
Early prediction of response to neoadjuvant chemotherapy (NAC) is critical in choosing appropriate chemotherapeutic regimen for patients with locally advanced breast cancer. Herein, we sought identify potential biomarkers predict the cancer patients.Three genomic profiles acquired by microarray analysis from subjects or without residual tumors after NAC downloaded GEO database were used screen differentially expressed genes (DEGs). An array public databases, including ONCOMINE, cBioportal,...
Thymocyte selection-associated high mobility group box (TOX) genes represent a novel family of genes. Deregulated expression TOXs has been reported in variety cancer types, including lung cancer. It also that are crucial regulators the immune system. The present study systematically evaluated prognostic values TOX members using set publicly accessible databases, Oncomine, Kaplan-Meier plotter and cBioPortal. was revealed profiles differed between normal tissues, mRNAs generally predicted...
Trastuzumab (Tmab) targeted therapy or its combination with chemotherapy is normally insufficient to elicit a comprehensive therapeutic response owing the inherent acquired drug resistance and systemic toxicity observed in highly invasive HER2-positive breast cancer. In this study, we propose novel approach that integrates photothermal (PTT) chemotherapy, thereby achieving additive synergistic outcomes. We utilize PEGylated two-dimensional black phosphorus (2D BP) as nanoplatform agent load...
We sought to determine the relationship between cancer-related fatigue, chemotherapy-associated adverse effects in patients with advanced stages of cancer, and levels TNF-α, IL-1 17-hydroxycorticosteroids (17-HCS).Two hundred cancer were recruited. They given a Cancer Fatigue Scale survey assess their general state health before after chemotherapy. Their plasma TNF-α urine 17-HCS also measured.Increased are common patients. Thirty-five (17.5%) suffered from effects, but not significantly...
As a critical transformational process in the attributes of epithelial cells, epithelial-to-mesenchymal transition (EMT) is involved tumor invasion, metastasis, and resistance to treatment, which contributes ultimate death some patients with breast cancer. Glycogen synthase kinase-3-beta (GSK3β) thought be an EMT suppressor that down-regulates protein, snail, zinc finger transcription inhibitor, regulates E-cadherin expression Wnt signaling pathway. Our previous studies have shown Notch3...
e13022 Background: The optimal treatment of HER2-positive advanced breast cancer (ABC) in later lines therapy remains undefined, especially after progression on previous monoclonal antibodies and tyrosine kinase inhibitors (TKI). Disitamab vedotin (RC48) is a novel self-developed, HER2-targeting ADC drug comprised hertuzumab coupling monomethyl auristatin E (MMAE) via cleavable linker China. This study aims to evaluate the effectiveness safety RC48 previously treated HER2+ ABC patients...