A5101438555- Prostate Cancer Diagnosis and Treatment
- Breast Implant and Reconstruction
- Prostate Cancer Treatment and Research
- Breast Cancer Treatment Studies
- Health Systems, Economic Evaluations, Quality of Life
- Reconstructive Surgery and Microvascular Techniques
- Corneal Surgery and Treatments
- Anorectal Disease Treatments and Outcomes
- Corneal surgery and disorders
- RNA modifications and cancer
- Cancer Risks and Factors
- Breast Lesions and Carcinomas
- Ferroptosis and cancer prognosis
- Health and Medical Studies
- Cancer Genomics and Diagnostics
- HER2/EGFR in Cancer Research
- Cancer Cells and Metastasis
- Microplastics and Plastic Pollution
- Lung Cancer Diagnosis and Treatment
- Ocular Oncology and Treatments
- Metabolism, Diabetes, and Cancer
- interferon and immune responses
- Clinical practice guidelines implementation
- Berberine and alkaloids research
- Congenital gastrointestinal and neural anomalies
Fudan University Shanghai Cancer Center
2014-2025
Karolinska Institutet
2021-2024
Longhua Hospital Shanghai University of Traditional Chinese Medicine
2023-2024
Shanghai University of Traditional Chinese Medicine
2023-2024
Cancer Hospital of Chinese Academy of Medical Sciences
2024
Chinese Academy of Sciences
2024
Shandong First Medical University
2024
Shandong Tumor Hospital
2024
Shanghai Medical College of Fudan University
2015-2023
Swedish e-Science Research Centre
2021
Importance The combination of prostate-specific antigen (PSA) testing with magnetic resonance imaging (MRI) for prostate cancer detection has rarely been evaluated in a screening context. STHLM3-MRI screening-by-invitation study ( NCT03377881 ) reported the benefits using MRI subsequent combined targeted and standard biopsies compared alone. Objective To investigate cost-effectiveness alone among men aged 55 to 69 years Sweden, based on evidence from study. Design, Setting, Participants This...
Introduction Despite its therapeutic advantages, postmastectomy radiotherapy (PMRT) increases the risk of complications and often leads to poor cosmesis in women undergoing breast reconstruction. Preoperative followed by skin-sparing mastectomy deep inferior epigastric perforator (DIEP) flap reconstruction is technically feasible, with low rates surgical good short-term oncological outcomes. Further evaluation a randomised trial comparing preoperative versus conventional PMRT required assess...
To understand the occurrence characteristics of microplastics in soil Xinxiang section Weihe River Basin, samples different types and layers were collected, identified using Agilent 8700 laser direct infrared （LDIR） chemical imaging system, ecological risks assessed polymer risk index （H） pollution load （PLI）. The results showed that proportions polyurethane （PU） polyethylene （PE） 17.57% 15.97%, respectively, Basin； particle diameter mainly ranged from 20 to 100 μm, 50 μm 76.17% 15.56%,...
Purpose Obesity is associated with poorer outcomes in patients hormone receptor-positive breast cancers, but this association not well established for women triple-negative cancers (TNBC). Here, we investigated the prognostic effects of body mass index (BMI) on clinical TNBC. Methods We identified 1106 TNBC who met inclusion criteria and were treated between January 2002 June 2012. Clinical biological features collected to evaluate relation BMI cancer-specific survival (BCSS) overall (OS)...
Background and objective Image-based artificial intelligence (AI) methods have shown high accuracy in prostate cancer (PCa) detection. Their impact on patient outcomes cost effectiveness comparison to human pathologists remains unknown. Our aim was evaluate the cost-effectiveness of AI-assisted pathology for PCa diagnosis Sweden. Methods We modeled quadrennial prostate-specific antigen (PSA) screening men between ages 50 74 yr over a lifetime horizon using health care perspective. Men with...
The clinical significance of progesterone receptor (PgR) expression in estrogen receptor-negative (ER–) breast cancer is controversial. Herein, we systemically investigate the clinicopathologic features, molecular essence, and endocrine responsiveness ER−/PgR+/HER2− phenotype. Four study cohorts were included. first second from Surveillance, Epidemiology, End Results database (n = 67,932) Fudan University Shanghai Cancer Center 2,338), respectively, for survival analysis. third fourth two...
Stockholm3 is a risk model that combines the prostate-specific antigen (PSA) test, other plasma protein biomarkers, single nucleotide polymorphisms, and clinical variables. The STHLM3-MRI study (NCT03377881) found test with magnetic resonance imaging (MRI) combined targeted systematic biopsies maintained sensitivity for clinically significant cancers, reduced number of benign insignificant cancers.To assess cost-effectiveness MRI-based screening prostate cancer using either as reflex or PSA...
The European Randomized Study of Screening for Prostate Cancer found that prostate-specific antigen (PSA) screening reduced prostate cancer mortality, however the costs and harms from may outweigh any mortality reduction. Compared with using PSA test alone, Stockholm3 Model (S3M) as a reflex ≥ 1 ng/mL has same sensitivity Gleason score 7 cancers while relative positive fractions 6 no were 0.83 0.56, respectively. cost-effectiveness S3M not previously been assessed.We undertook analysis...
ObjectiveThis study aimed to assess the cost-effectiveness of magnetic resonance imaging (MRI) with combinations targeted biopsy (TBx) and systematic (SBx) for early prostate cancer detection in Sweden.MethodsA cost-utility analysis was conducted from a lifetime societal perspective using microsimulation model. Five strategies included no screening quadrennial men aged 55 69 years SBx alone, TBx on positive MRI (MRI + TBx), combined TBx/SBx TBx/SBx), negative − SBx, TBx/SBx). Test...
Sinomenine was found to play anti-cancer functions in different type of cancers, while the mechanisms underlying anticancer effects sinomenine retinoblastoma (RB) remains unclear. The present study designed explore impacts on cell proliferation and invasion ability RB cells related mechanism. Human line WERI-RB-1 Y79 were cultured treated by concentration sinomenine, then determined via performing 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. apoptosis examined...
Retinoblastoma (RB) is a highly malignant eye tumor with low survival rate and high metastatic rate. The current work was designed to investigate the potential roles of microRNA-144 (miR-144) in diagnosis prognosis RB.miR-144 expression levels RB tissues adjacent normal tissues, as well serum samples from patients healthy controls were measured. association between miR-144 clinical features analyzed. Moreover, diagnostic prognostic values verified by receiver operating characteristic...
Abstract: Diagnostic patterns in breast cancer have greatly changed over the past few decades, and core needle biopsy (CNB) has become a reliable procedure for detecting without invasive surgery. To estimate changing diagnostic of urban Shanghai, 11,947 women with lesions detected by preoperative between January 1995 December 2012 were selected from Shanghai Cancer Data base, which integrates information approximately 50% patients Shanghai. The CNB uses an automated prone unit, gun, 14-gauge...
The latissimus dorsi flap (LDF) is the most commonly used autologous for breast reconstruction (BR) in China. We conducted this study to explore current status of BR using LDF with/without implants.This was a single-center retrospective that included tumor patients who underwent at Fudan University Shanghai Cancer Center (FUSCC) between 2000 and 2021.We analyzed 4918 postmastectomy BR, including 1730 (35.2%) with flaps. 1093 (22.2%) patients, an abdominal 637 (13.0%) patients. proportion...
ABSTRACT The introduction of tyrosine kinase inhibitors has considerably improved the life expectancy (LE) for patients with chronic myeloid leukemia (CML). Evaluating health‐related quality within treatment pathway remains crucial. Using Swedish CML register, we included 991 adult chronic‐phase (CP) diagnosed 2007 to 2017, follow‐up until 2018. We developed a multistate model estimate loss in LE (LLE) and quality‐adjusted (LQALE) patient population compared general population, along...
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It is crucial for clinical decision-making to identify non-small cell lung cancer (NSCLC) patients who are likely achieve major pathological remission (MPR) following neoadjuvant immunotherapy and chemotherapy (NICT). Our study involved an analysis of 243 NSCLC from three centers, treated with NICT surgery categorized into training, validation test cohorts. We conducted extensive the tumor area, examining intra-tumoral zone surrounding peri-tumoral regions at 2 mm, 4 mm 6 developing...
Abstract Background Limited data are available regarding the risk factors for fistula-in-ano (FIA) in infants and toddlers, potentially affecting their daily lives. Objectives The purpose of this study was to identify potential FIA order implement early preventive interventions, avoid disease progression, develop therapeutic strategies. Design settings A retrospective case-control conducted, comparing 41 toddlers diagnosed with healthy controls, between August 2020 December 2021. Independent...
Serpin B9 is highly expressed in breast cancer, melanoma, and various malignant cells inhibits NK cell killing through the B9-GrB axle. However, current studies have only validated role of vivo vitro, lack systematic on expression patients' tumor tissues its prognostic implications. In this study, we propose to further validate by comparing level lung adenocarcinoma patients correlation with efficacy immunotherapy. This study included 200 LUAD between Feb 2022 2023. IHC scoring assessed...