A5082685159- Breast Cancer Treatment Studies
- Breast Lesions and Carcinomas
- Breast Implant and Reconstruction
- Ultrasound Imaging and Elastography
- Cancer Cells and Metastasis
- Ultrasonics and Acoustic Wave Propagation
- Cancer Genomics and Diagnostics
- Photoacoustic and Ultrasonic Imaging
- Cancer Research and Treatments
- Cancer, Hypoxia, and Metabolism
- Cancer and Skin Lesions
- Angiogenesis and VEGF in Cancer
- Reconstructive Facial Surgery Techniques
- Colorectal Cancer Treatments and Studies
- Gastric Cancer Management and Outcomes
- Lung Cancer Treatments and Mutations
- Cancer-related molecular mechanisms research
- Amino Acid Enzymes and Metabolism
- Reconstructive Surgery and Microvascular Techniques
- Thyroid Cancer Diagnosis and Treatment
- Drug Transport and Resistance Mechanisms
- Biopolymer Synthesis and Applications
- Cancer Treatment and Pharmacology
- RNA modifications and cancer
- HER2/EGFR in Cancer Research
Fudan University Shanghai Cancer Center
2010-2024
Shanghai Medical College of Fudan University
1998-2019
Sun Yat-sen University
2016
Sun Yat-sen University Cancer Center
2016
A new human hepatocellular carcinoma (HCC) cell line with a highly metastatic potential was established from subcutaneous xenograft of model HCC in nude mice (LCI-D20) by means alternating culture vitro and growth mice. The line, designated MHCC97, has been cultivated for 18 months subcultured more than 90 passages. showed to be origin karyotype analysis. cells were either grown as compact colonies (in clusters) or monolayered sheet about 31 h population-doubling time, exhibited typical...
The aim of the study was to review surgical trends in breast cancer treatment China over past 15 years and explore possible factors related choice modality. medical records 18,502 patients with unilateral early stage who underwent surgery from January 1999 December 2013 at our institute were retrospectively reviewed. utilization different modalities associated clinicopathological analyzed. Furthermore, prognostic role modality also evaluated. median patient age 50.0 years. According pTNM...
Ultrasound shear-wave elastography (SWE) may increase specificity of breast lesion assessment with ultrasound, but elasticity measurements change transducer orientation, defined as anisotropy. In this study, we aimed to observe the anisotropy SWE lesions, and its correlation clinical histopathological findings.This retrospective study was approved by institutional review board. From June 2014 2015, a total 276 women (mean age, 48.75 ± 12.12 years) lesions (174 malignant, 102 benign) were...
Since mastectomy remained the primary strategy for treating breast cancer in China, post-mastectomy reconstruction is of great importance Chinese population. The current study aimed to assess status China.We reviewed all patients who received from August 2000 July 2015 Department Breast Surgery our institute. Patients' baseline characteristics, strategy, final pathology and loco-regional recurrence (LRR) information were collected.A total 951 reconstructions conducted during past 15 years,...
Background The aim of the present study was to investigate potential risk factors for synchronous bilateral breast cancer sBBC). Methods A retrospective analysis performed patients diagnosed and treated with operable (BBC) between June 2007 December 2011. Risk sBBC were evaluated in this cohort further validated a prospective observational validation January 2012 2012. Patients unilateral during same period used as control group. Results total 11,247 primary underwent operations at Fudan...
Background The aim of this study was to investigate the current surgical management strategy for bilateral breast cancer (BBC) patients and assess changes in China. Methods This is a retrospective review all with early-stage BBC who underwent treatment at Fudan University Shanghai Cancer Center between June 2007 2014. Results A total 15,337 primary were identified. Of these patients, 218 (1.5%) suffered from synchronous (sBBC), 296 (2.0%) metachronous (mBBC). Patients lobular carcinoma...
The visualization of microvasculature is an essential step in understanding the mechanisms underlying early vessel disorders involved breast cancer and for developing effective therapeutic strategies. However, generating detailed reproducible data using immunohistochemistry analysis angiogenesis has been difficult.To analyze diversification development tumor growth evaluate anti-vascular effects Avastin (bevacizumab), we used new X-ray microangiography third-generation synchrotron...
Color patterns of 3-dimensional (3D) shear wave elastography (SWE) is a promising method in differentiating tumoral nodules recently. This study was to evaluate the diagnostic accuracy color 3D SWE breast lesions, with special emphasis on coronal planes. A total 198 consecutive women lesions (125 malignant and 73 benign) were included, who underwent conventional ultrasound (US), B-mode, before surgical excision. Views (transverse), T (sagittal), C (coronal) determined. Sensitivity,...
Accurate intraoperative diagnosis of sentinel node metastasis enables the surgeon to make an immediate decision proceed axillary lymph dissection (ALND), thereby avoiding economic and psychological costs a second operation. The present study aimed evaluate clinical value touch imprint cytology (TIC) investigate potential factors associated with misdiagnosis. A total 366 patients Tis-T2 breast carcinoma were included after undergoing successful biopsy (SLNB). TIC was routinely performed...
The management of axillary lymph nodes in early-stage breast cancer patients has changed considerably, with the primary focus shifting from examination sentinel (SLNs) to toward detection all macro-metastases. However, current methods, such as touch imprint cytology (TIC) and frozen sections, are inadequate for clinical needs. To address this issue, we proposed a novel miniaturised epifluorescence widefield microscope (MEW-M) assess SLN status intraoperatively improved diagnostic...
Abstract The aim of this study was to investigate the trends axillary lymph node evaluation in ductal carcinoma situ ( DCIS ) patients treated with breast‐conserving therapy BCT and identify clinicopathological predictors evaluation. 2006–2015 at our institute were retrospectively included analysis. Patients categorized into three groups: sentinel biopsy SLNB ), dissection ALND non‐evaluation. Univariate multivariate logistic regression analyses performed factors that predicted A total 315...
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Neoadjuvant therapy, as an important part of comprehensive treatment for locally advanced gastric cancer, has been recommended by various guidelines. Partial cancer patients can achieve pathologic complete response (pCR) after neoadjuvant thus achieving relatively good prognosis. However, there is still controversy over whether remission in local pathology translate into survival benefits, pCR equivalent to cure, and subsequent adjuvant therapy needed. Therefore, how predict who identify...
Abstract Purpose: In previous study, we had shown that miR-621 could sensitize breast cancer to chemotherapy by suppressing FBXO11 and enhancing p53 activity. this aimed define prognosis value in patients, explore the potential molecular mechanisms. Experimental Design: 70 patients with stages II III were included as validation set. The correlation between expression level was confirmed. parallel, vitro vivo analyses carried out determine mechanisms of miRNA-dependent prognosis. Results: We...